UAlberta researchers have created two new imaging agents that could help physicians visualize the formation of tumour-associated blood vessels, keep track of tumour growth and possibly generate new therapies (Nanoscale, “Viral nanoparticles decorated with novel EGFL7 ligands enable intravital imaging of tumor neovasculature”).
“Blood vessel growth is critical to tumour growth,” said John Lewis, the Alberta Cancer Foundation Frank and Carla Sojonky Chair in Prostate Cancer Research at the U of A and a member of the Cancer Research Institute of Northern Alberta (CRINA). “When a tumour starts growing, cells start to divide out of control and they lack an organized blood vessel network to feed them. When that happens, there are help signals that tell the surrounding blood vessels to branch off and supply the tumour with new blood vessels for oxygen and nutrients.”
The process is called angiogenesis. There are a number of approved cancer drugs to prevent the formation of new tumour-related blood vessels, but according to Lewis, many haven’t yet lived up to their promise due to wide variability among patients. He believes the newly created imaging agents, which can be used in PET scans and fluorescence imaging, could provide physicians helpful insight when determining the best course of action for their patients.
“These drugs can be toxic and expensive, but potentially life-saving for certain patients. An imaging agent could be used before treatment to see how many new blood vessels are forming to determine whether an individual patient is a candidate for treatments that will inhibit new blood vessel growth.’ This would allow treatment to be personalized for those patients most likely to respond. Also, during the treatment, you could use the same imaging agent to monitor the response to the therapy.”
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