Modern Approaches to Augmentation of Brain Function
This book covers recent advances in neural technology that provide for enhancements for brain function. It addresses a broad range of neural phenomena occurring in the brain circuits involved in perception, cognition, emotion and action, that represent the building blocks of behavior and cognition. Augmentation of brain function can be achieved by using brain implants for recordings, stimulation, or drug delivery. Alternative methods include employing brain-machine interfaces, as well as noninvasive activation of certain brain areas. This volume evaluates existing methods of brain augmentation while discussing the brain circuitry and neuronal mechanisms that make augmentation possible.
This volume offers novel insights into brain disorders, and explores new devices for brain repair while also addressing the philosophical and ethical implications of brain augmentation. The information in this book is relevant to researchers in the fields of neuroscience, engineering, and clinical practice.
Advance Praise for Modern Approaches to Augmentation of Brain Function:
“This impressive book by leading experts in neuroscience and neuroengineering lays out the future of brain augmentation, in which the human mind and machine merge, leading to a rapid exponential growth of the power of humanity.”
Ray Kurzweil, best-selling author, inventor, entrepreneur and a recipient of the National Medal of Technology and Innovation (1999), and the Lemelson-MIT Prize (2001)
“This book employs a holistic approach in covering the recent advances in the fields of neuroscience, neuroinformatics, neurotechnology and neuro-psycho-pharmacology. Each chapter of the book covers major aspects of modern brain research in connection with the human mind and behavior, and is authored by researchers with unique expertise in their field. ”
Ioan Dumitrache, Prof. Dr. Eng. Faculty of Computer Science, Polytechnic University of Bucharest, Bucharest, Romania
“This book presents compelling perspectives on what interactive neuroscience will look like in the future, delving into the innovatory ideas of a diverse set of neuroscientists, and speculating on the different ways computer chips implanted in the brains of humans can effect intelligence and communication.”
György Buzsáki, MD, PhD is the Biggs Professor of Neuroscience, NYU School of Medicine, New York, NY
Immune Aspects of Biopharmaceuticals and Nanomedicines
1st Edition
Raj Bawa, Janos Szebeni, Thomas J Webster, Gerald F. Audette
The enormous advances in the immunology of biotherapeutics and nanomedicines in the past two decades have necessitated an authoritative and comprehensive reference that can be relied upon by immunologists, biomedical researchers, physicians, pharmaceutical and formulation scientists, clinicians, regulatory personnel, technology transfer officers, venture capitalists, and policy makers alike.
Table of Contents
Proteins as Medicines: The Era of Biologics
Raj Bawa, János Szebeni, Thomas J. Webster, and Gerald F. Audette
Immunological Issues with Medicines of Nano Size: The Price of Dimension Paradox
János Szebeni and Raj Bawa
Immunotherapy and Vaccines
Johanna Poecheim and Gerrit Borchard
Emerging Trends in Delivery of Novel Vaccine Formulations
Trinh Phuong Vo, Rikhav P. Gala, Thripthy Chandran, Sucheta D’Sa, and Ruhi V. Ubale
Current Understanding of Interactions between Nanoparticles and the Immune System
Marina A. Dobrovolskaia, Michael Shurin, and Anna A. Shvedova
Auto-antibodies as Biomarkers for Disease Diagnosis
Angelika Lueking, Heike Göhler, and Peter Schulz-Knappe
The Accelerated Blood Clearance Phenomenon of PEGylated Nanocarriers
Amr S. Abu Lila and Tatsuhiro Ishida
Anti-PEG Immunity Against PEGylated Therapeutics
Amr S. Abu Lila and Tatsuhiro Ishida
Complement Activation: Challenges to Nanomedicine Development
Dennis E. Hourcade, Christine T. N. Pham, and Gregory M. Lanza
Intravenous Immunoglobulin at the Borderline of Nanomedicines and Biologicals: Antithrombogenic Effect via Complement Attenuation
Milan Basta
Lessons Learned from the Porcine CARPA Model: Constant and Variable Responses to Different Nanomedicines and Administration Protocols
Rudolf Urbanics, Péter Bedőcs, and János Szebeni
Blood Cell Changes in Complement Activation-Related Pseudoallergy: Intertwining of Cellular and Humoral Interactions
Zsófia Patkó and János Szebeni
Immune Reactions in the Delivery of RNA Interference-Based Therapeutics: Mechanisms and Opportunities
Kaushik Thanki, Emily Falkenberg, Monique Gangloff, and Camilla Foged
Lipid Nanoparticles Technology Induced Immunomodulatory Effects of siRNA
Ranjita Shegokar and Prabhat Mishra
Nanovaccines against Intracellular Pathogens Using Coxiella burnetii as a Model Organism
Erin J. van Schaik, Anthony E. Gregory, Gerald F. Audette, and James E. Samuel
Immunogenicity Assessment for Therapeutic Protein Products
FDA
Assay Development and Validation for Immunogenicity Testing of Therapeutic Protein Products: Guidance for Industry
FDA
The “Sentinel”: A Nanomedical Strategy for Radical Immune System Enhancement
Frank Boehm and Angelika Domschke
Immunotherapy for Gliomas and Other Intracranial Malignancies
Mario Ganau, Gianfranco K. I. Ligarotti, Salvatore Chibbaro, and Andrea Soddu
Liposome-Induced Complement Activation-Related Pseudoallergy
Amr S. Abu Lila, Janos Szebeni, and Tatsuhiro Ishida
The Physics of the Mind and Brain Disorders
Frank Boehm (NanoApps Medical CEO) and Angelika Domschke contributed the chapter : “Application of a Conceptual Nanomedical Platform to Facilitate the Mapping of the Human Brain: Survey of Cognitive Functions and Implications”.
The book covers recent advances in the understanding of brain structure, function and disorders based on the fundamental principles of physics. It covers a broad range of physical phenomena occurring in the brain circuits for perception, cognition, emotion and action, representing the building blocks of the mind.
It provides novel insights into the devastating brain disorders of the mind such as schizophrenia, dementia, autism, aging or addictions, as well as into the new devices for brain repair.
The book is aimed at basic researchers in the fields of neuroscience, physics, biophysics and clinicians in the fields of neurology, neurosurgery, psychology, psychiatry.
The Physics of the Mind and Brain Disorders is available in both hardcover and ebook from Springer Press.
Neurophotonics and Brain Mapping
Frank Boehm contributed to Neurophotonics and Brain Mapping, edited by Yu Chen and Babek Kateb.
The book was released by CRC Press on April 6 2017.
About the Book
Understanding how the brain works and developing effective therapeutics are important in advancing neuroscience and improving clinical patient care. This book covers state-of-the-art research and development in optical technologies and applications for brain mapping and therapeutics. It provides a comprehensive overview of various methods developed using light, both microscopic and macroscopic techniques. Recent developments in minimally-invasive endoscopic imaging of deep brain structure and function, as well as light-based therapy are also reviewed.
Frank Boehm contributed to “Brief History of Brain Mapping and Neurophotonics: From Technological Discoveries to Brain Initiatives” by Babak Kateb, Vicky Yamamoto, Frank Boehm, Alexandra Jalali, Vassiliy Tsytsarev, Bahram Jalali, Derek Backer,Brian Pikul, Parham Yashar, and Yu Chen. He also contributed to the chapter “UV-Based Imaging Technologies for Intraoperative Brain Mapping” by Babak Kateb, Frank Boehm, Ray Chu, Samuel R. Cheng, Keith Black, and Shouleh Nikzad.
Chapters contributed to the following books:
1) Chapter 15: “Potential Strategies for Advanced Nanomedical Device Ingress and Egress, Natation, Mobility, and Navigation”,
Frank J. Boehm
in
Mark J. Schulz, Vesselin N. Shanov, YeoHeung Yun, eds., Nanomedicine Materials, Devices, and Systems, Artech House, (Norwood MA, USA)
http://www.amazon.com/Nanomedicine-Particles-Implants-Engineering-Medicine/dp/1596932791
(published August 1, 2009)
2) “The Vascular Cartographic Scanning Nanodevice”
Frank J. Boehm
in
Handbook of Clinical Nanomedicine, Two-Volume Set
Raj Bawa, Gerald F. Audette, Israel Rubinstein
Pan Stanford
https://www.crcpress.com/Handbook-of-Clinical-Nanomedicine-Two-Volume-Set/Bawa-Audette-Rubinstein/p/book/9789814316170
(published May 12, 2016)
3) “UV-Based Imaging Technologies for Intraoperative Brain Mapping”
Babak Kateb, Frank Boehm, Ray Chu, Shouleh Nikzad
in
Neurophotonics and Brain Mapping
Yu Chen, Babak Kateb
https://www.crcpress.com/Neurophotonics-and-Brain-Mapping/Chen-Kateb/p/book/9781482236859
(forthcoming April 6, 2017)
4) “Application of a Conceptual Nanomedical Platform to Facilitate the Mapping of the Human Brain: Survey of Cognitive Functions and Implications”
A. Domschke and F.J. Boehm
in
The Physics of the Mind and Brain Disorders
Integrated Neural Circuits Supporting the Emergence of Mind
Editors: Dr. Ioan Opris, Manuel F. Casanova
http://www.springer.com/us/book/9783319296722
(forthcoming Jul 11, 2017)
5) “The “Sentinel”: A Conceptual Nanomedical Strategy for the Enhancement of the Human Immune System”
A. Domschke and F.J. Boehm
in
Handbook of Clinical Nanomedicine – Volume 3
Raj Bawa, Gerald F. Audette, Israel Rubinstein
(forthcoming tbd)
Journal Publications
“Superseding the Hourglass Effect Toward the Successful Commercialization of Nanotechnology in the Medical Sciences – We Require a Change in Perspective”
Krishnan Chakravarthy, Frank Boehm, and Wendy Sanhai-Madar
Cureus. 2016 Jul; 8(7): e670. Published online 2016 Jul 5.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977221/
“Nanotechnology: Promising New Paradigm for the Control of Pain”
Krishnan Chakravarthy MD, PhD, Frank Boehm, and Paul Christo MD, MBA
(in progress, journal publication – tbd)
“Facilitating a Hypothetical (Neocortical) Brain/Cloud Interface (B/CI) – Conceptual Nanomedical Strategies”
Martins NRB, Angelica A, Chakravarthy K, Svidinenko Y, Boehm FJ, Opris I, Lebedev M, Swan M, Rosenfeld JV, Hogg T, Freitas Jr RA
(in progress, journal publication – tbd)
“Facilitating a Hypothetical (Neocortical) Brain/Cloud Interface (B/CI) – Ethical, Moral, Sociological, and Philosophical Considerations”
Martins NRB, Angelica A, Chakravarthy K, Svidinenko Y, Boehm FJ, Opris I, Lebedev M, Swan M, Rosenfeld JV, Hogg T, Freitas Jr RA
(in progress, journal publication – tbd)
Citations
“Determination of hemodynamic risk for vascular disease in planar artery bifurcations”
Otero-Cacho A, Aymerich M, Flores-Arias MT, Abal M, Álvarez E, Pérez-Muñuzuri V, Muñuzuri AP.
Scientific Reports, 12 February 2018(8), 2795
www.nature.com
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By eavesdropping on the brains of living people, scientists have created the highest-resolution map yet of the neurons that encode the meanings of various words1. The results hint that, across [...]
Re-engineering cancerous tumors to self-destruct and kill drug-resistant cells
Treating cancer can sometimes feel like a game of Whac-A-Mole. The disease can become resistant to treatment, and clinicians never know when, where and what resistance might emerge, leaving [...]
Research could help drug developers improve the safety profiles of medications
Research from the University of British Columbia, MIT, and the University of Michigan could help drug developers improve the safety profiles of medications and reduce side effects. Chemists have [...]
New lab test to detect persistent HIV strains in Africa may aid search for cure
A multinational team led by Weill Cornell Medicine investigators developed a test that will help measure the persistence of HIV in people affected by viral strains found predominantly [...]
Nasal COVID-19 Vaccine Secures Federal Funding for Groundbreaking Clinical Trial
The trial will evaluate the effectiveness and safety of a new vaccine compared to an FDA-approved mRNA vaccine. University of Georgia-based startup CyanVac LLC has received federal funding to conduct a [...]
Scientists closing in on why some people never get COVID.
Early on in the pandemic, in 2021, Hugh Potter ate dinner and watched TV next to his wife while she coughed violently from COVID-19, yet he never even sniffled. [...]
Help or hindrance? ER robots have potential to aid health care workers
Amid the unpredictability and occasional chaos of emergency rooms, a robot has the potential to assist health care workers and support clinical teamwork, Cornell and Michigan State University [...]
For tendon healing: Nanoparticles for precision drug delivery
Harnessing nanoparticles to deliver drugs precisely to a surgically repaired tendon is a promising new approach that reduced scar tissue formation and improved mechanical function. Researchers' success in pinpointing [...]
Gold nanoparticles kill cancer – but not as thought
Gold particles of the size of billionths of a meter are lethal to cancer cells. This fact has been known for a long time, as has a simple correlation: [...]
Beyond Einstein: Exploring Spacetime Through Finsler Geometry
Investigations into gravitational waves and their relationship with Finsler geometry are providing new insights into spacetime, suggesting ways to harmonize relativity and quantum mechanics. When speaking of our universe, it’s often [...]
Revolutionizing Regeneration: Rat Stem Cells Restore Mouse Brain Circuits
Research teams have successfully regenerated mouse brain circuits using rat stem cells, showcasing a new method for restoring brain function and studying interspecies brain development. These findings open up [...]
Meet the Virus-Killing Plastic That’s Changing the COVID Game
Studies at the University of Jyväskylä in Finland show that resin-treated plastics can quickly deactivate viruses, part of a larger effort under the BIOPROT project to develop bio-based antiviral [...]
Study shows familiarity with gene editing increases approval of the safety of GMOs
The more that people know about gene editing, the more likely they are to feel it is safe to use in agriculture and medicine, according to a survey of [...]
Study finds connection between cannabis use and increased risk of severe COVID-19
As the deadly disease that came to be known as COVID-19 started spreading in late 2019, scientists rushed to answer a critical question: Who is most at risk? They [...]
New Bioplastic Straw Degrades Even Faster in the Ocean Than Paper
Researchers determine the lifetimes of commercial drinking straws in the coastal ocean and develop a prototype bioplastic straw that degrades even faster than paper. A WHOI study has shown [...]
Scientists Discover Unexpected Importance of “Time Cells” for Complex Learning
Researchers at the University of Utah Health found that “time cells” in mice adapt to learning timed tasks, a discovery that could aid early Alzheimer’s detection by monitoring changes in a [...]
Mussel-Inspired Technique Paves Way for Efficient Nanoparticle Assembly
Nanoscale materials offer remarkable chemical and physical properties that transform theoretical applications, like single-molecule sensing and minimally invasive photothermal therapy, into practical realities. The unparalleled features of nanoparticles make [...]
All the Data on Earth Can Fit in a Cup Full of DNA – MIT’s Jurassic Park-Inspired Project
Since the early days of computer science, scientists have been exploring the idea of using DNA to store data. MIT has developed an amber-like polymer that can keep DNA [...]
Novel approach enables bidirectional brain-computer interface functionality
Brain-computer interfaces, or BCIs, hold immense potential for individuals with a wide range of neurological conditions, but the road to implementation is long and nuanced for both the invasive [...]
Decoding Mental Health With Advanced Brain Gene Maps
Groundbreaking maps reveal the complex gene regulation in brains with and without mental disorders, enhancing the understanding of mental illnesses and potential treatments. A consortium of researchers has produced [...]
Biological Differences in How Men and Women Perceive Pain Discovered
Researchers have discovered sex-specific differences in the nerve cells that generate pain, paving the way for personalized pain management treatments based on patient sex. Research indicates that men and [...]
Scientists May Have Discovered the First Sign of Autism: An Unusually Large Brain
Researchers at the University of California San Diego discovered that an unusually large brain could be the first sign of autism, potentially detectable in as early as the first [...]
$100M Funding – Phase 3 trial of first oral disease-modifying therapy for Alzheimer’s.
Clinical-stage biotech Alzheon has completed a $100 million Series E financing round to advance the development and commercialization of its oral drug for Alzheimer’s disease. The drug, called ALZ-801 (valiltramiprosate), is [...]
‘Dual mutant’ seasonal flu virus could make some treatments ineffective
Two human cases of "dual mutant" strains of H1N1 flu have been reported by U.S. health officials. Unfortunately, the genetic changes appear to render the leading flu antiviral, Tamiflu, less effective, [...]
Mutation Mystery Solved: Why Lung Cancer Treatments Often Fail in Non-Smokers
Researchers have discovered the reason why targeted treatment for non-small cell lung cancer fails to work for some patients, particularly those who have never smoked. The study shows that [...]
Innovative blood test boosts accuracy of lung cancer screening
In a recent study published in Cancer Discovery, researchers developed and validated a blood-based, cell-free deoxyribonucleic acid (cfDNA) fragmentome assay for lung cancer detection, which, if the results were positive, [...]
Researchers Uncover Significant Cognitive Differences Between Male and Female Brains
Research from Weill Cornell Medicine reveals that astrocyte receptors impact cognitive functions differently in males and females, suggesting a need for sex-specific approaches in developing treatments targeting these brain [...]
Columbia Scientists Unravel a 15-Year Mistake in Stem Cell Research
Columbia University’s research has uncovered a longstanding error in identifying gut stem cells, finding the true stem cells in a different site, which could revolutionize regenerative medicine by applying [...]
