For many of us, Covid-19 feels like a chapter we've closed – along with the days of PCR tests, mask mandates and daily case updates. But while life may feel back to normal, the virus hasn't completely vanished. In fact, new variants continue to quietly circulate.
One of the latest to appear on the radar is NB.1.8.1 – a name that you may have seen pop up in headlines and on social media feeds this week.
This newly emerging sub-variant hasn't triggered widespread concern, but it has caught the attention of scientists and health officials.
The UK Health Security Agency (UKHSA) announced this week that NB.1.8.1 has so far only been detected in small numbers within the UK, but added that international data indicates that the sub-variant is steadily accounting for a growing share of global Covid-19 cases.
We consulted some GPs to find out exactly what sets the NB.1.8.1 Covid variant apart from the rest. Is it more contagious, more immune-evasive, or simply another step in Covid's slow evolution? Here's what they know so far…
What is the new NB.1.8.1 Covid variant and where has it come from?
"The NB.1.8.1 variant, also referred to as Nimbus, is a new strain of the Covid-19 virus that has emerged due to mutations in its genetic material," says Dr Naveed Asif, GP at The London General Practice.
It's a sub-variant of Omicron, says Dr Chun Tang, GP at Pall Mall Medical.
"Variants like this pop up when the virus mutates, which is normal for viruses, especially ones that spread widely," explains Tang. "NB.1.8.1 was first picked up in early 2025 and has since been detected in several countries, including the UK, China and US. It's got some new mutations that scientists are keeping a close eye on."
How is it different from previous variants?
"NB.1.8.1 isn't too different from the Omicron variant, but it does have some tweaks to its spike protein, which might make it spread a bit more easily or slip past some of our existing immunity," says Tang. "That said, early signs suggest it doesn't seem to cause more serious illness, but of course, we're still learning more about it."
However, Nimbus does appear to be more transmissible than previous variants, with notable increases reported in India, Hong Kong, Singapore, and Thailand, notes Asif.
"Its spread has been identified in around 22 countries," says Asif. "The World Health Organization (WHO) assesses the additional risk to the global public as currently low, and existing Covid-19 vaccines are considered effective in preventing severe disease."
How is it spreading?
"It's spreading in the usual way, person to person, mainly through respiratory droplets when people cough, sneeze or even just talk closely," says Tang. "Like other variants, it can hang around in the air in poorly ventilated spaces."
What symptoms should people look out for?
"Common symptoms of the NB.1.8.1 variant include severe sore throat (described as a "razor blade sensation"), fatigue, mild cough, fever, muscle aches and congestion," says Asif. "However, symptoms can vary widely so vigilance is key."
What are the treatment options?
"Treatment for Nimbus generally aligns with that for other Covid-19 variants," says Asif. "Most individuals will recover at home with rest, hydration, and over-the-counter medications for symptom management.
"For those with severe symptoms or high-risk complications, antiviral medications or monoclonal antibody treatments may be recommended. Always consult your GP for personalised advice."
How can you avoid getting the new variant?
"Make sure everyone's up to date with their Covid-19 jabs, especially boosters," recommends Tang. "Wash your hands regularly, keep rooms well ventilated, and consider popping a mask on in busy places or if you're around people who are more vulnerable.
"If someone in the house is feeling poorly, try to keep some distance and clean shared surfaces regularly."
When should you see a GP about this?
"Seek medical advice if you experience Covid-19 symptoms, especially if they worsen or if you have underlying health conditions that increase your risk," advises Asif. "Additionally, consult your GP if you've been in close contact with someone who has tested positive for the NB.1.8.1 variant or if you have health concerns."
News
GLP-1 Drugs Like Ozempic Work, but New Research Reveals a Major Catch
Three new Cochrane reviews find evidence that GLP-1 drugs lead to clinically meaningful weight loss, though industry-funded studies raise concerns. Three new reviews from Cochrane have found that GLP-1 medications can lead to significant [...]
How a Palm-Sized Laser Could Change Medicine and Manufacturing
Researchers have developed an innovative and versatile system designed for a new generation of short-pulse lasers. Lasers that produce extremely short bursts of light are known for their remarkable precision, making them indispensable tools [...]
New nanoparticles stimulate the immune system to attack ovarian tumors
Cancer immunotherapy, which uses drugs that stimulate the body’s immune cells to attack tumors, is a promising approach to treating many types of cancer. However, it doesn’t work well for some tumors, including ovarian [...]
New Drug Kills Cancer 20,000x More Effectively With No Detectable Side Effects
By restructuring a common chemotherapy drug, scientists increased its potency by 20,000 times. In a significant step forward for cancer therapy, researchers at Northwestern University have redesigned the molecular structure of a well-known chemotherapy drug, greatly [...]
Lipid nanoparticles discovered that can deliver mRNA directly into heart muscle cells
Cardiovascular disease continues to be the leading cause of death worldwide. But advances in heart-failure therapeutics have stalled, largely due to the difficulty of delivering treatments at the cellular level. Now, a UC Berkeley-led [...]
The basic mechanisms of visual attention emerged over 500 million years ago, study suggests
The brain does not need its sophisticated cortex to interpret the visual world. A new study published in PLOS Biology demonstrates that a much older structure, the superior colliculus, contains the necessary circuitry to perform the [...]
AI Is Overheating. This New Technology Could Be the Fix
Engineers have developed a passive evaporative cooling membrane that dramatically improves heat removal for electronics and data centers Engineers at the University of California San Diego have created an innovative cooling system designed to greatly enhance [...]
New nanomedicine wipes out leukemia in animal study
In a promising advance for cancer treatment, Northwestern University scientists have re-engineered the molecular structure of a common chemotherapy drug, making it dramatically more soluble and effective and less toxic. In the new study, [...]
Mystery Solved: Scientists Find Cause for Unexplained, Deadly Diseases
A study reveals that a protein called RPA is essential for maintaining chromosome stability by stimulating telomerase. New findings from the University of Wisconsin-Madison suggest that problems with a key protein that helps preserve chromosome stability [...]
Nanotech Blocks Infection and Speed Up Chronic Wound Recovery
A new nanotech-based formulation using quercetin and omega-3 fatty acids shows promise in halting bacterial biofilms and boosting skin cell repair. Scientists have developed a nanotechnology-based treatment to fight bacterial biofilms in wound infections. The [...]
Researchers propose five key questions for effective adoption of AI in clinical practice
While Artificial Intelligence (AI) can be a powerful tool that physicians can use to help diagnose their patients and has great potential to improve accuracy, efficiency and patient safety, it has its drawbacks. It [...]
Advancements and clinical translation of intelligent nanodrugs for breast cancer treatment
A comprehensive review in "Biofunct. Mater." meticulously details the most recent advancements and clinical translation of intelligent nanodrugs for breast cancer treatment. This paper presents an exhaustive overview of subtype-specific nanostrategies, the clinical benefits [...]
It’s Not “All in Your Head”: Scientists Develop Revolutionary Blood Test for Chronic Fatigue Syndrome
A 96% accurate blood test for ME/CFS could transform diagnosis and pave the way for future long COVID detection. Researchers from the University of East Anglia and Oxford Biodynamics have created a highly accurate [...]
How Far Can the Body Go? Scientists Find the Ultimate Limit of Human Endurance
Even the most elite endurance athletes can’t outrun biology. A new study finds that humans hit a metabolic ceiling at about 2.5 times their resting energy burn. When ultra-runners take on races that last [...]
World’s Rivers “Overdosing” on Human Antibiotics, Study Finds
Researchers estimate that approximately 8,500 tons of antibiotics enter river systems each year after passing through the human body and wastewater treatment processes. Rivers spanning millions of kilometers across the globe are contaminated with [...]
Yale Scientists Solve a Century-Old Brain Wave Mystery
Yale scientists traced gamma brain waves to thalamus-cortex interactions. The discovery could reveal how brain rhythms shape perception and disease. For more than a century, scientists have observed rhythmic waves of synchronized neuronal activity [...]















