Viruses as Controllable Nanodevices

Viruses are Nature’s delivery vehicles. Millions of years of evolution have molded them into remarkable machines capable of performing a monumental task vital to their survival: the delivery of genetic material into other organisms.

Viruses are shells made up of proteins and sometimes lipids that carry genetic information into cells. The type of genetic material (DNA or RNA), shape, size, and the process of delivery differ between different virus families.

Current state-of-the-art research uses bio-mined viruses as blueprints for the creation of new materials and therapeutics that can benefit humanity. For example, the field of gene therapy harnesses the efficient ability of viruses to infect host cells and turns them into delivery vehicles for the genetic treatment of people suffering from debilitating diseases and disorders.

The US Food and Drug Administration recently approved Luxturna—a gene therapy drug that uses a benign virus for the treatment of hereditary blindness in children. This is the first gene therapy product for a genetic disease approved for clinical use in the US, and has opened the gates for approval of other virus-based therapies for treatment of genetic diseases, including hemophilia, Duchenne muscular dystrophy, and cystic fibrosis. In order to continue advances in such applied areas, more knowledge about how viruses work and how to control their functions is needed.

Read more at advancedsciencenews.com

Image Credit:    CC0 Public Domain 

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