Cells contain thousands of messenger RNA molecules, which carry copies of DNA’s genetic instructions to the rest of the cell. MIT engineers have now developed a way to visualize these molecules in higher resolution than previously possible in intact tissues, allowing researchers to precisely map the location of RNA throughout cells.
Key to the new technique is expanding the tissue before imaging it. By making the sample physically larger, it can be imaged with very high resolution using ordinary microscopes commonly found in research labs.
“Now we can image RNA with great spatial precision, thanks to the expansion process, and we also can do it more easily in large intact tissues,” says Ed Boyden, an associate professor of biological engineering and brain and cognitive sciences at MIT, a member of MIT’s Media Lab and McGovern Institute for Brain Research, and the senior author of a paper describing the technique in the July 4, 2016 issue of Nature Methods
C. diff might not originate from external transmission but rather from within the infected patient themselves. Hospital staff dedicate significant effort to safeguard patients from infections during their hospital [...]
Moderna has developed a new and improved version of its COVID-19 vaccine. The unique formulation (mRNA-1283) reduces the vaccine's content from the full-length SARS-CoV-2 spike protein to a narrowly [...]
Breast cancer in its various forms affects more than 250,000 Americans a year. One particularly aggressive and hard-to-treat type is triple-negative breast cancer (TNBC), which lacks specific receptors targeted [...]
Scientists from Nanyang Technological University, Singapore (NTU Singapore) have created a process that can upcycle most plastics into chemical ingredients useful for energy storage, using light-emitting diodes (LEDs) and [...]
Scientists from ETH Zurich and the University of Geneva have developed a new technique that allows them to observe chemical reactions taking place in liquids at extremely high temporal resolution. This innovation enables [...]
Research published recently suggests that Pfizer’s erectile dysfunction drug Viagra can decrease the risk of developing Alzheimer’s disease by up to 69 percent. The research, which was published in Nature, [...]
Cancer biomarkers circulating in body fluids can be used for diagnosis and treatment monitoring. However, current detection technology lacks the required sensitivity, limiting biomarker use in clinical applications. Colorectal [...]
The findings could lead to a cure for LAM. Researchers from the University of Cincinnati may have identified a potential treatment for lymphangioleiomyomatosis (LAM), a rare lung condition resembling cancer found [...]
A recent study reveals oscillations in the refractive index that are faster than can be explained by current theories. A study recently published in the journal Nanophotonics reveals that by rapidly [...]
Researchers from Stanford Medicine have discovered that cancer cells-to-be accumulate a series of specific genetic changes in a predictable and sequential way years before they are identifiable as pre-malignancies. Many of [...]
A novel antibiotic named Clovibactin, extracted from previously uncultivable bacteria, has been found effective against harmful bacteria, including multi-resistant “superbugs”. Clovibactin’s unique mechanism of targeting multiple essential precursor [...]
Nanofitins, which are derived from a protein found in Sulfolobus acidocaldarius—an archaeal microorganism found in hot springs—successfully neutralized SARS-CoV-2 in mice and were well-tolerated. When inhaled by the rodents, [...]
New research reveals that functional connectivity can distinguish between various disease subtypes. Not only is major depressive disorder (MDD) one of the most prevalent mental health conditions, affecting more [...]
A recent study from Yale indicates that additional chromosomes in cancer cells are essential for the growth of tumors. Removing these extra chromosomes inhibits tumor formation. The findings, said the researchers, [...]
An MD Anderson study provides a deeper understanding of the progression of gastric cancer and highlights a potential therapeutic target. A recent study conducted by scientists at The University of [...]
The findings could potentially improve the success rate of cancer drug development. Approximately 90% of drugs don’t reach the market, highlighting the clear need for increased efficiency in drug [...]
The World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) are tracking and studying a highly mutated new variant of the virus that causes COVID-19. Officially titled BA.2.86 and nicknamed Pirola [...]
Clinical studies reveal extended survival in diffuse midline glioma patients receiving ONC201 treatment; research also explains the underlying mechanism of the drug’s success. For the first time, a potential [...]
Researchers at Albert Einstein College of Medicine have found that the virus responsible for chikungunya fever can spread directly from cell to cell—perhaps solving the longstanding mystery of how the virus, [...]
Two molecular languages at the origin of life have been successfully recreated and mathematically validated, thanks to pioneering work by Canadian scientists at Université de Montréal. Living organisms are [...]
Using machine learning to improve living. A groundbreaking machine-learning study has revealed the optimal drug combinations to prevent the recurrence of COVID-19 after initial infection. Interestingly, the ideal combination differs among [...]
A team of bioengineers and biomedical scientists from the University of Sydney and the Children's Medical Research Institute (CMRI) at Westmead have used 3D photolithographic printing to create a [...]
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