A research team has developed a nano-platform technology that works in combination with existing chemotherapeutic drugs that may reverse drug-resistance in renal cell carcinoma.
Drug resistance to chemotherapy is a significant clinical and financial burden in renal cell carcinoma and other types of cancers. The resistance can be caused by hypoxia, a decreased level of oxygen in the tumour cells and infiltration of tumour-promoting immune cells aiding the tumor growth in contrast to fighting against it.
To alleviate the drug resistance, Arun Iyer Assistant Professor of Pharmaceutical Sciences in the Eugene Applebaum College of Pharmacy and Health Sciences at Wayne State University, and co-investigator and lead author of the work, Dr Samaresh Sau, research associate in the Department of Pharmaceutical Sciences in the Eugene Applebaum College of Pharmacy and Health Sciences, set out to find a way to use tumor hypoxia-directed nanoparticles to attack the root cause of the problem.
“Our tumour hypoxia directed nanoparticle used in conjunction with the FDA-approved renal cell carcinoma treatment, Sorafenib, has had positive outcomes in our animal trials,” said Iyer Assistant Professor of Pharmaceutical Sciences in the Eugene Applebaum College of Pharmacy and Health Sciences at Wayne State University. “The nanoparticles can deliver the payload selectively to tumour tissue and penetrate deep into the tumour core and provoke significant tumor inhibition with marked safety.”
According to the duo, the results have shown that this targeted approach has great benefits.
Image Credit: DTR
Thanks to Dr. ir Johannes Drooghaag. Follow him on twitter:@DrJDrooghaag
News This Week
Frank Boehm: Publication of our new paper “Human Brain/Cloud Interface” in Frontiers in Neuroscience
Contributors: Nuno R. B. Martins, Amara Angelica, Yuriy Svidinenko, Frank J. Boehm, Ioan Opris, Mikhail A. Lebedev, Melanie Swan, Steven A. Garan, Jeffrey V. Rosenfeld, Tad Hogg, Robert A. Freitas Jr. et al Excerpt [...]
Which Nanobasics Should Be Taught in Medical Schools?
Abstract The progressive growth in nanotechnology approaches to diagnostics and therapeutics, especially for cancer, necessitates training physicians in nanoethics. This article explains why it is critical for medical education to include instruction in [...]
A mysterious infection, spanning the globe in a climate of secrecy
The rise of Candida auris embodies a serious and growing public health threat: drug-resistant germs. In May, an elderly man was admitted to the Brooklyn branch of Mount Sinai Hospital for abdominal surgery. A [...]
Squeezed nanocrystals: A new model predicts their shape when blanketed under graphene
In a collaboration between the U.S. Department of Energy's Ames Laboratory and Northeastern University, scientists have developed a model for predicting the shape of metal nanocrystals or "islands" sandwiched between or below two-dimensional (2D) [...]
How gene-drive technology could help eradicate malaria
Should we be prepared to change the population composition of a species in order to wipe out a disease that is a terrible burden to mankind? During a well-attended working breakfast organised by the [...]
Visualizing the Healthtech Revolution
Imagine being a patient in the early 19th century, when all ailments were considered “humors” to be ejected from the body. To restore balance, various techniques such as diets, natural herbs, or bloodletting with [...]
Low-dose radiation therapy improves delivery of therapeutic nanoparticles to brain tumors
A new study led by Massachusetts General Hospital (MGH) investigators finds that radiation therapy may increase the uptake of therapeutic nanoparticles by glioblastomas, raising the possibility of using both growth-factor-targeted and immune-system-based therapies against [...]
How A.I. Is Finding New Cures in Old Drugs
Pharma startups like Pharnext are deploying machine learning to search for new therapeutic uses for “off patent” medications. In the elegant quiet of the café at the Church of Sweden, a narrow Gothic-style building [...]
“Particle robot” works as a cluster of simple units
Taking a cue from biological cells, researchers from MIT, Columbia University, and elsewhere have developed computationally simple robots that connect in large groups to move around, transport objects, and complete other tasks. This [...]
How AI Could Help Cardiologists Detect Heart Defects Without Skipping a Beat
Nearly a third of physicians will be sued at least once in their careers — most commonly for an error in diagnosis. Medical errors are also the third-leading cause of death in the United [...]
Nano-bot can probe inside human cells
University of Toronto Engineering researchers have built a set of magnetic 'tweezers' that can position a nano-scale bead inside a human cell in three dimensions with unprecedented precision. The nano-bot has already been used [...]
Graphene Shows Promise for Repairing Broken Bones
When you were a kid, did you ever sign a classmate’s cast after they broke an arm or a leg? Your name would be on display there for the rest of the semester. Broken [...]
What Are Nanobots? What Are Their Future Implications?
Inventors and scientists have been continuously working towards reducing the size of technological components. Room-sized computers to laptops that are slimmer than a pane of glass? It’s done. Huge bulky telephones to smartphones that [...]
Robotics These Nano-Robots Are Super-Tiny And Can Walk Inside Your Body
You have witnessed a variety of nano-devices that were designed for tasks including delivering medicines within the body. All of them used to move in a variety of ways. However, the latest nano-device is [...]
Nanosponges sop up toxins and help repair tissues
To take his fledgling lab to new heights, Liangfang Zhang hatched a plan that he considered brilliant in its simplicity. It involved procedures that many of his peers found a little out there. But [...]
U of T Engineering Science student investigating the use of nanomedicine in cancer research
Netra Rajesh is an undergraduate Engineering Science student specializing in Biomedical Systems Engineering. She is currently on her Professional Experience Year (PEY) at the Massachusetts Institute of Technology where her research lies at the [...]
Leave A Comment