The rising concern of plastic pollution and the increase in nanoplastics, which are small plastic debris particles with nanoscale sizes between 1 and 1000 nm, have become a field of research that has garnered popularity over recent years. Innovative research published in the journal, ACS Omega, has investigated the effect of nanoplastics on developing zebrafish embryos.
Nanoplastic Pollution
Nanoplastic pollution is a significant rising concern for public health and the environment.
Plastics, which have become a ubiquitous waste material found in landfills and the oceans, have been a growing concern due to their lack of biodegradability. Additionally, the eroding of large plastics into nanosize can be more detrimental for the environment and human health, with nanosized particles causing more damage.
(a) Scheme for preparation of the polypropylene nanoplastics (PPNPs) using a modified nonsolvent-induced phase separation (NIPS) method. (b) SEM images and the size distribution (n = 100). © Lee, W., Kim, H., Sim, Y., Kang, T. and Jeong, J., (2022)
With physiochemical properties associated with nanosized plastics, they can interact with biological systems, leading to disastrous effects. Additionally, nanoplastic pollution may not be purified by wastewater treatment systems.
It can be found in drinking water, causing them to be ingested; resultant oxidative stress and inflammation have been reported in diverse organisms. This can also occur through its ability to penetrate human tissue by crossing the lungs, skin and gastrointestinal barriers – which can be deleterious for health.
Plastic types that are a risk and constitute plastic debris include polystyrene, polyethylene, and polypropylene (PP). Polystyrene has largely been responsible for the risk that nanoplastics hold due to its commercial availability of various sizes and surface charges; however, while this plastic has high usage, polyethylene and polypropylene are ubiquitously detected in plastic debris in the environment.
While polypropylene is abundant in the environment, there are limited studies on this plastic type. Regardless, its incorporation as the most used plastic, such as within food packaging, automotive components, and even personal protective equipment (PPE), including masks that have increased during the COVID-19 pandemic, raises the concern for plastic pollution.
The accumulation of PP into microplastics such as UV radiation, oxidation, and biofilms can be a health risk with the detection of PP being found gastrointestinal tracts of sea turtles on the Atlantic coastline of Florida after only being post-hatched for 96 hours. Additionally, PP microplastics were found to induce cytotoxicity, proinflammatory cytokine production, oxidative stress and intestinal damage in human-derived cell and animal models such as zebrafish.
With the disastrous effect of microplastics on both the environment and human health, fragmentation into nanosized particles could be potentially further hazardous. This plastic pollution, which is a major concern due to associated plastic manufacturing, requires further research to understand the effects of polypropylene nanoplastics.
Innovative Nanoplastic Research
The researchers of this innovative study aimed to investigate the biological effects of nanoscale polypropylene in an animal model utilizing developing zebrafish embryos.
The team produced PPNPs utilizing a high yield method, including nonsolvent-induced phase separation; they fabricated PPNPs within a spherical shape with an average diameter of 562.15 ± 118.47 nm. They were then fluorescently labeled utilizing the combined swelling-diffusion method to investigate and observe the biodistribution of these particles after being exposed to developing zebrafish embryos.
Interestingly, the researchers found the fluorescent-labeled polypropylene nanoplastics internalized through ingestion and found even in the intestines of developing zebrafish embryos before being eventually excreted.
(a) Scheme of fluorescence labeling of PPNPs by the CSD method. (b) Photographs of PP pellets, PPNPs, and R-PPNP suspension in DW under visible light (left), UV light (365 nm, middle), and visible light with laser beam (right). (c) FT-IR spectra, (d) fluorescence spectra, and (e) fluorescence stability of RBITC and R-PPNPs. © Lee, W., Kim, H., Sim, Y., Kang, T. and Jeong, J., (2022)
Significant Implications for Environmental and Human Health
Overcoming the limitations of prior investigations into polypropylene plastic pollution, this novel research has uncovered the significant effect that nanoplastics can have on biological systems.
The team has raised awareness of the biodistribution of nanoplastics, especially polypropylene, which is found significantly in plastic debris within the environment. This study can be a basis for further research into the effect that nanoplastics can have on biological systems, such as focusing on oxidative stress and potential interactions that may cause harm for human health if ingested.
The research team can also aid in bringing awareness to the significance of nanoplastic pollution and its effects on the environment, with microplastic awareness being provided with traction. This can translate to reducing the manufacturing of polypropylene-based plastics, including finding other biodegradable plastics for applications, including PPE, which has become an increasing concern for plastic pollution.
Creating biodegradable plastics can ease plastic pollution and advancement in wastewater treatments can reduce any harmful effects these plastics can have on animal and human health.
Optical and fluorescence images of zebrafish embryos with or without R-PPNP treatments at 24 and 72 hpf. These images were taken after 24 h exposure. © Lee, W., Kim, H., Sim, Y., Kang, T. and Jeong, J., (2022)
News
How Are Hydrogels Shaping the Future of Biomedicine?
Hydrogels have gained widespread recognition and utilization in biomedical engineering, with their applications dating back to the 1960s when they were first used in contact lens production. Hydrogels are distinguished from other biomaterials in [...]
Nanovials method for immune cell screening uncovers receptors that target prostate cancer
A recent UCLA study demonstrates a new process for screening T cells, part of the body's natural defenses, for characteristics vital to the success of cell-based treatments. The method filters T cells based on [...]
New Research Reveals That Your Sense of Smell May Be Smarter Than You Think
A new study published in the Journal of Neuroscience indicates that the sense of smell is significantly influenced by cues from other senses, whereas the senses of sight and hearing are much less affected. A popular [...]
Deadly bacteria show thirst for human blood: the phenomenon of bacterial vampirism
Some of the world's deadliest bacteria seek out and feed on human blood, a newly-discovered phenomenon researchers are calling "bacterial vampirism." A team led by Washington State University researchers has found the bacteria are [...]
Organ Architects: The Remarkable Cells Shaping Our Development
Finding your way through the winding streets of certain cities can be a real challenge without a map. To orient ourselves, we rely on a variety of information, including digital maps on our phones, [...]
Novel hydrogel removes microplastics from water
Microplastics pose a great threat to human health. These tiny plastic debris can enter our bodies through the water we drink and increase the risk of illnesses. They are also an environmental hazard; found [...]
Researchers Discover New Origin of Deep Brain Waves
Understanding hippocampal activity could improve sleep and cognition therapies. Researchers from the University of California, Irvine’s biomedical engineering department have discovered a new origin for two essential brain waves—slow waves and sleep spindles—that are critical for [...]
The Lifelong Cost of Surviving COVID: Scientists Uncover Long-Term Effects
Many of the individuals released to long-term acute care facilities suffered from conditions that lasted for over a year. Researchers at UC San Francisco studied COVID-19 patients in the United States who survived some of the longest and [...]
Previously Unknown Rogue Immune Key to Chronic Viral Infections Discovered
Scientists discovered a previously unidentified rogue immune cell linked to poor antibody responses in chronic viral infections. Australian researchers have discovered a previously unknown rogue immune cell that can cause poor antibody responses in [...]
Nature’s Betrayal: Unmasking Lead Lurking in Herbal Medicine
A case of lead poisoning due to Ayurvedic medicine use demonstrates the importance of patient history in diagnosis and the need for public health collaboration to prevent similar risks. An article in CMAJ (Canadian Medical Association [...]
Frozen in Time: How a DNA Anomaly Misled Scientists for Centuries
An enormous meteor spelled doom for most dinosaurs 65 million years ago. But not all. In the aftermath of the extinction event, birds — technically dinosaurs themselves — flourished. Scientists have spent centuries trying [...]
‘Mini kidneys’ reveal new insights into metabolic defects in polycystic kidney disease
Scientists at Nanyang Technological University, Singapore (NTU Singapore) have successfully grown 'mini kidneys' in the lab and grafted them into live mice, revealing new insights into the metabolic defects and a potential therapy for [...]
Decoding the Origin of Life: Scientists Solve Early Earth RNA Puzzle
Recent research illustrates how RNA molecules’ chemical characteristics might have played a crucial role in the development of complex life forms. How did complex life manage to evolve on the early, inhospitable Earth? Initially, [...]
Improving infectious disease testing with gold nanoparticles
By harnessing the power of composite polymer particles adorned with gold nanoparticles, a group of researchers have delivered a more accurate means of testing for infectious diseases. Details of their research was published in the [...]
New micromaterial releases nanoparticles that selectively destroy cancer cells
Researchers have developed micromaterials made up only of proteins, capable of delivering over an extended period of time nanoparticles that attack specific cancer cells and destroy them. The micromaterials mimic natural secretory granules found [...]
Alzheimer’s Breakthrough: Scientists Make Revolutionary Leap
Dementia is a major health issue worldwide in the 21st century, impacting over 50 million people globally. This figure is expected to soar to 152 million by 2050, as the global population ages. Alzheimer’s disease (AD) [...]