Scientists have built microscopic robots equipped with electronic "brains" that are capable of walking autonomously.
A team from Cornell University in the US developed the solar-powered bots as part of research into a new generation of tiny devices that can perform roles ranging from performing microsurgery, to cleaning the inside of arteries.
The microrobots measure just 250 micrometres across – smaller than the head of an ant – and can operate without any external controls.
"Before, we literally had to manipulate these 'strings' in order to get any kind of response from the robot," said Itai Cohen, a professor of physics at Cornell.
"But now that we have these brains on board, it's like taking the strings off the marionette. It's like when Pinocchio gains consciousness."
The breakthrough involves a complementary metal-oxide-semiconductor (CMOS) clock circuit, which can hold thousands of transistors capable of generating frequencies that set the gait of the robot.
The extremely low energy demands of the onboard circuit and platinum-based legs mean that they can be powered by tiny photovoltaic cells.
The system was used on three different types of microrobot: a two-legged version, a four-legged "dogbot", and a six-legged "antbot".
Commands can be sent to control the speed via laser pulse, with Professor Cohen claiming that the onboard "brains" would allow the bots to communicate with researchers and figure out how to carry out the instructions.
"Then we're having a conversation with the robot," he said. "The robot might tell us something about its environment, and then we might react by telling it, 'OK, go over there and try to suss out what's happening.'
"The real fun part is, just like we never really knew what the iPhone was going to be about until we sent it out into the world, what we're hoping is that now that we've shown the recipe for linking CMOS electronics to robotic actuating limbs, we can unleash this and have people design low-power microchips that can do all sorts of things."
The high degree of programmability could lead to a wide range of applications in medicine, according to lead researcher Dr Michael Reynolds, such as identifying good cells and killing bad cells."
A paper detailing the research, titled 'Microscopic robots with onboard digital controls', was published this week in the journal Science Robotics.

News
Scientists Discover a New Form of Ice That Shouldn’t Exist
Researchers at the European XFEL and DESY are investigating unusual forms of ice that can exist at room temperature when subjected to extreme pressure. Ice comes in many forms, even when made of nothing but water [...]
Nobel-winning, tiny ‘sponge crystals’ with an astonishing amount of inner space
The 2025 Nobel Prize in chemistry was awarded to Richard Robson, Susumu Kitagawa and Omar Yaghi on Oct. 8, 2025, for the development of metal-organic frameworks, or MOFs, which are tunable crystal structures with extremely [...]
Harnessing Green-Synthesized Nanoparticles for Water Purification
A new review reveals how plant- and microbe-derived nanoparticles can power next-gen water disinfection, delivering cleaner, safer water without the environmental cost of traditional treatments. A recent review published in Nanomaterials highlights the potential of green-synthesized nanomaterials (GSNMs) in [...]
Brainstem damage found to be behind long-lasting effects of severe Covid-19
Damage to the brainstem - the brain's 'control center' - is behind long-lasting physical and psychiatric effects of severe Covid-19 infection, a study suggests. Using ultra-high-resolution scanners that can see the living brain in [...]
CT scan changes over one year predict outcomes in fibrotic lung disease
Researchers at National Jewish Health have shown that subtle increases in lung scarring, detected by an artificial intelligence-based tool on CT scans taken one year apart, are associated with disease progression and survival in [...]
AI Spots Hidden Signs of Disease Before Symptoms Appear
Researchers suggest that examining the inner workings of cells more closely could help physicians detect diseases earlier and more accurately match patients with effective therapies. Researchers at McGill University have created an artificial intelligence tool capable of uncovering [...]
Breakthrough Blood Test Detects Head and Neck Cancer up to 10 Years Before Symptoms
Mass General Brigham’s HPV-DeepSeek test enables much earlier cancer detection through a blood sample, creating a new opportunity for screening HPV-related head and neck cancers. Human papillomavirus (HPV) is responsible for about 70% of [...]
Study of 86 chikungunya outbreaks reveals unpredictability in size and severity
The symptoms come on quickly—acute fever, followed by debilitating joint pain that can last for months. Though rarely fatal, the chikungunya virus, a mosquito-borne illness, can be particularly severe for high-risk individuals, including newborns and older [...]
Tiny Fat Messengers May Link Obesity to Alzheimer’s Plaque Buildup
Summary: A groundbreaking study reveals how obesity may drive Alzheimer’s disease through tiny messengers called extracellular vesicles released from fat tissue. These vesicles carry lipids that alter how quickly amyloid-β plaques form, a hallmark of [...]
Ozone exposure weakens lung function and reshapes the oral microbiome
Scientists reveal that short-term ozone inhalation doesn’t just harm the lungs; it reshapes the microbes in your mouth, with men facing the greatest risks. Ozone is a toxic environmental pollutant with wide-ranging effects on [...]
New study reveals molecular basis of Long COVID brain fog
Even though many years have passed since the start of the COVID-19 pandemic, the effects of infection with SARS-CoV-2 are not completely understood. This is especially true for Long COVID, a chronic condition that [...]
Scientists make huge Parkinson’s breakthrough as they discover ‘protein trigger’
Scientists have, for the first time, directly visualised the protein clusters in the brain believed to trigger Parkinson's disease, bringing them one step closer to potential treatments. Parkinson's is a progressive incurable neurological disorder [...]
Alpha amino acids’ stability may explain their role as early life’s protein building blocks
A new study from the Hebrew University of Jerusalem published in the Proceedings of the National Academy of Sciences sheds light on one of life's greatest mysteries: why biology is based on a very specific set [...]
3D bioprinting advances enable creation of artificial blood vessels with layered structures
To explore possible treatments for various diseases, either animal models or human cell cultures are usually used first; however, animal models do not always mimic human diseases well, and cultures are far removed [...]
Drinking less water daily spikes your stress hormone
Researchers discovered that people who don’t drink enough water react with sharper cortisol spikes during stressful events, explaining why poor hydration is tied to long-term health risks. A recent study in the Journal of Applied [...]
Nanomed Trials Surge Highlighting Need for Standardization
Researchers have identified over 4,000 nanomedical clinical trials in progress now, highlighting rapid growth in the field and the need for a standardized lexicon to support clinical translation and collaboration. Nanotechnology is the science of [...]