Microplastics found in prostate tumors in small study

In a new study, researchers found microplastics deep inside prostate cancer tumors, raising more questions about the role the ubiquitous pollutants play in public health.

The findings — which come from a small study of 10 men — were presented Monday at the American Society of Clinical Oncology’s Genitourinary Cancers Symposium and have not yet been published in a peer-reviewed journal.

In the study, researchers analyzed tissue samples taken from 10 men with prostate cancer, with an average age of 65, whose prostate had been removed as part of their treatment for the disease. They also analyzed noncancerous tissue taken from the opposite side of the organ.

Microplastics were present in 90% of the tumors and 70% of the noncancerous samples. The cancerous tissue contained 2.5 times the amount of plastic on average than the noncancerous tissue with approximately 40 micrograms of plastic per gram of tissue.

Dr. Stacy Loeb, the lead study author and a urologist at NYU Langone Health, said the higher concentrations in the tumor tissue “was very surprising and concerning.”

It “raised questions over whether it could have an association with the development of prostate cancer,” she said. “So this is definitely something we’re going to continue to study further with more cases.”

Dr. Michael Eisenberg, a urology professor at the Stanford University School of Medicine, who wasn’t involved in the study, said that the new research does not establish cause and effect.

However, “we are finding many signals about the astonishing prevalences of micro/nanoplastics and the concerning associations with health problems,” he wrote in an email. “We need more data to understand the implications of these findings.”

The study is not the first to find microplastics in prostate cancer tumors. A 2024 study published in The Lancet from researchers in China also found higher levels of plastics in tumors compared to nearby tissue. Loeb said the new study used more precise techniques to measure the different plastics found in the samples. The researchers also took extensive steps to avoid contamination that could’ve skewed the results.

The ubiquity of plastic makes studying the presence of microplastics in human tissue challenging — was the plastic actually found in the body, or was it introduced through plastic used in the research? Previous studies that have identified microplastics in postmortem brain tissue and carotid artery plaques have been criticized for their methodology, including suggestions that the measurements may have been influenced by lab contamination.

With this mind, Loeb said, extra stringent precautions were taken in her study, which took a year of planning. When conducting the surgical prostate removal, she said, plastic was eliminated from the operating room as much as possible and the team deliberately accounted for contamination in their analysis.

“I would say, if anything, this might have been overly conservative, because the samples we took were from deep in the middle of the prostate, so it’s unclear how much anything could have actually touched these samples,” Loeb said. “The tumor and the benign tissue samples were from the same patient and underwent exactly the same handling, so the fact that we’re seeing a high concentration of plastics in the tumor can’t really easily be explained by a contamination.”

Dr. Andrea Viale, an associate professor in the department of genomic medicine, at the MD Anderson Cancer Center in Houston, said that while the results don’t establish a causal relationship between microplastics and prostate cancer, they show that this needs to be taken seriously as a possible theory for the rising rates of advanced disease.

Around 1 in 8 men in the U.S. will be diagnosed with prostate cancer at some point in their lifetime, according to the American Cancer Society. Over the past decade, cases of late-stage disease have increased annually by 2.6% in men under 55, 6% in men ages 55–69, and 6.2% in men 70 and older.

“The fact that it is being detected in tumors, means that from a public health perspective, this issue deserves really serious attention,” said Viale, who was not involved with the study. “We should really begin implementing strategies to limit the exposure, because we do not know what it’s actually doing, but it is something that should not be there.”

According to Eisenberg, microplastics could be driving higher levels of oxidative damage to cells in the prostate, as well as impacting immune function. Loeb said they might also be increasing inflammation in the tissue, as well as helping transport potentially carcinogenic chemicals such as phthalates and bisphenols into the prostate. Greater exposure to these chemicals, which are commonly found in plastic packaging, has previously been associated with prostate cancer.

At the same time, pinning down whether plastic particles are playing a role in the development or progression of the disease will be far from straightforward.

“The challenging problem is that when you talk about plastic, you have dozens of polymers, shapes, sizes, geometries, and plastic contains tens of different chemicals, additives, stabilizers, plasticizers, dyes and contaminants as well, so it’s really difficult to understand the causative role,” Viale said. “It could be playing a physical role in the tissue, or it could be related to the chemical composition of the plastic itself.”

Loeb and her colleagues have already secured a grant from the Defense Department, now rebranded the Department of War, for a larger study, analyzing the amount of plastic in tissue samples from 30 prostate cancer patients, as well as assessing whether there is a link between the quantity of plastic and the amount of inflammation in the tissue.

In future research, Loeb said she would also like to compare the prevalence of plastic in high-grade or aggressive prostate tumors, versus low-grade tumors. She’s also calling for similar studies from other research groups in more patient populations to try and confirm this apparent link.

“The bottom line is that this study is just preliminary data, so we’re nowhere near the point of saying that this causes prostate cancer,” she said. “But I think more needs to be done to determine whether that is a possibility.”