An electrochemical process developed at Georgia Tech could offer new protection against bacterial infections without contributing to growing antibiotic resistance.
The approach capitalizes on the natural antibacterial properties of copper and creates incredibly small needle-like structures on the surface of stainless steel to kill harmful bacteria like E. coli and Staphylococcus. It’s convenient and inexpensive, and it could reduce the need for chemicals and antibiotics in hospitals, kitchens, and other settings where surface contamination can lead to serious illness.
It also could save lives: A global study of drug-resistant infections found they directly killed 1.27 million people in 2019 and contributed to nearly 5 million other deaths—making these infections one of the leading causes of death for every age group.
Researchers described the copper-stainless steel and its effectiveness May 20 in the journal Small.
“Killing Gram-positive bacteria without chemicals is comparatively easy but tackling Gram-negative bacteria poses a significant challenge, due to their thick, multilayered cell membrane. And if these bacteria persist on surfaces, they can grow rapidly,” said Anuja Tripathi, the study’s lead author and a postdoctoral scholar in the School of Chemical and Biomolecular Engineering. “I aimed to develop an antibiotic-free bactericidal surface effective against Gram-negative and Gram-positive bacteria.”
Tripathi and her colleagues—William R. McLain Professor Julie Champion and former Ph.D. students Jaeyoung Park and Thomas Pho—produced a one-two punch that overcomes those challenges and doesn’t help bacteria develop resistance to drugs.
The team first developed an electrochemical method to etch the surface of stainless steel, creating nano-sized needle-like structures on the surface that can puncture bacteria’s cell membranes. Then, with a second electrochemical process, the researchers deposited copper ions on the steel’s surface.
Copper interacts with the cell membranes and ultimately compromises them.
“The nanotextured stainless steel can kill both Gram-negative and Gram-positive bacteria, but we wanted to enhance the antibacterial activity for surfaces that can be highly contaminated,” Tripathi said. “The copper coating on the nanotextured stainless steel gave us very high antibacterial activity.”
and c,e) nanotextured stainless steel etched for 30 s at 8 V. Credit: Small (2024). DOI: 10.1002/smll.202311546
Despite copper’s known antibacterial properties, it’s not widely used to fight surface contamination because it’s expensive. Tripathi’s approach deposits only a thin layer of copper ions on the stainless steel, so it’s cost-effective without compromising the material’s antibacterial activity.
Together, the dual attacks resulted in 97% reduction of Gram-negative E. coli and 99% reduction in Gram-positive Staphylococcus epidermis bacteria in the group’s study.
Tripathi said the stainless steel could be used for common tools in medical settings that are easily fouled, such as scissors or tweezers. It could be used for door handles, stair railings, and perhaps even sinks—places where stainless steel is often the material of choice and surface bacteria are common, especially in hospitals or other shared settings.
The process she and her colleagues developed also could be useful in food service. Tripathi said the approach could be fairly easily incorporated into existing industrial processes, where different electrochemical coating methods already are used for stainless steel food storage containers.
Tripathi said future work will investigate if the copper-coated, nanotextured stainless steel is effective against other kinds of cells harmful to human health. She’s also interested in exploring whether the steel could be used for medical implants to help ward off infections.
Since it proved effective against troublesome E. coli, she’s hopeful.
“Reflecting on a recent E. coli outbreak in grocery stores in Calgary, Canada, I was particularly driven in my research, recognizing the urgent relevance and significance of combating such resilient bacteria on surfaces,” Tripathi said. “They can be difficult to eliminate. So, if we can effectively eliminate E. coli, we stand a good chance of eradicating many bacteria on surfaces.”
More information: Anuja Tripathi et al, Dual Antibacterial Properties of Copper‐Coated Nanotextured Stainless Steel, Small (2024). DOI: 10.1002/smll.202311546
Journal information: Small
Provided by Georgia Institute of Technology

News
By working together, cells can extend their senses beyond their direct environment
The story of the princess and the pea evokes an image of a highly sensitive young royal woman so refined, she can sense a pea under a stack of mattresses. When it comes to [...]
Overworked Brain Cells May Hold the Key to Parkinson’s
Scientists at Gladstone Institutes uncovered a surprising reason why dopamine-producing neurons, crucial for smooth body movements, die in Parkinson’s disease. In mice, when these neurons were kept overactive for weeks, they began to falter, [...]
Old tires find new life: Rubber particles strengthen superhydrophobic coatings against corrosion
Development of highly robust superhydrophobic anti-corrosion coating using recycled tire rubber particles. Superhydrophobic materials offer a strategy for developing marine anti-corrosion materials due to their low solid-liquid contact area and low surface energy. However, [...]
This implant could soon allow you to read minds
Mind reading: Long a science fiction fantasy, today an increasingly concrete scientific goal. Researchers at Stanford University have succeeded in decoding internal language in real time thanks to a brain implant and artificial intelligence. [...]
A New Weapon Against Cancer: Cold Plasma Destroys Hidden Tumor Cells
Cold plasma penetrates deep into tumors and attacks cancer cells. Short-lived molecules were identified as key drivers. Scientists at the Leibniz Institute for Plasma Science and Technology (INP), working with colleagues from Greifswald University Hospital and [...]
This Common Sleep Aid May Also Protect Your Brain From Alzheimer’s
Lemborexant and similar sleep medications show potential for treating tau-related disorders, including Alzheimer’s disease. New research from Washington University School of Medicine in St. Louis shows that a commonly used sleep medication can restore normal sleep patterns and [...]
Sugar-Coated Nanoparticles Boost Cancer Drug Efficacy
A team of researchers at the University of Mississippi has discovered that coating cancer treatment carrying nanoparticles in a sugar-like material increases their treatment efficacy. They reported their findings in Advanced Healthcare Materials. Over a tenth of breast [...]
Nanoparticle-Based Vaccine Shows Promise in Fighting Cancer
In a study published in OncoImmunology, researchers from the German Cancer Research Center and Heidelberg University have created a therapeutic vaccine that mobilizes the immune system to target cancer cells. The researchers demonstrated that virus peptides combined [...]
Quantitative imaging method reveals how cells rapidly sort and transport lipids
Lipids are difficult to detect with light microscopy. Using a new chemical labeling strategy, a Dresden-based team led by André Nadler at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and [...]
Ancient DNA reveals cause of world’s first recorded pandemic
Scientists have confirmed that the Justinian Plague, the world’s first recorded pandemic, was caused by Yersinia pestis, the same bacterium behind the Black Death. Dating back some 1,500 years and long described in historical texts but [...]
“AI Is Not Intelligent at All” – Expert Warns of Worldwide Threat to Human Dignity
Opaque AI systems risk undermining human rights and dignity. Global cooperation is needed to ensure protection. The rise of artificial intelligence (AI) has changed how people interact, but it also poses a global risk to human [...]
Nanomotors: Where Are They Now?
First introduced in 2004, nanomotors have steadily advanced from a scientific curiosity to a practical technology with wide-ranging applications. This article explores the key developments, recent innovations, and major uses of nanomotors today. A [...]
Study Finds 95% of Tested Beers Contain Toxic “Forever Chemicals”
Researchers found PFAS in 95% of tested beers, with the highest levels linked to contaminated local water sources. Per- and polyfluoroalkyl substances (PFAS), better known as forever chemicals, are gaining notoriety for their ability [...]
Long COVID Symptoms Are Closer To A Stroke Or Parkinson’s Disease Than Fatigue
When most people get sick with COVID-19 today, they think of it as a brief illness, similar to a cold. However, for a large number of people, the illness doesn't end there. The World [...]
The world’s first AI Hospital, developed in China is transforming healthcare
Artificial Intelligence and its developments have had a revolutionary impact on society, and healthcare is not an exception. China has made massive strides in AI integrated healthcare, and continues to do so as AI [...]
Scientists Rewire Immune Cells To Supercharge Cancer-Fighting Power
Blocking a single protein boosts T cell metabolism and tumor-fighting strength. The discovery could lead to next-generation cancer immunotherapies. Scientists have identified a strategy to greatly enhance the cancer-fighting abilities of the immune system’s [...]