Moderna has developed a new and improved version of its COVID-19 vaccine. The unique formulation (mRNA-1283) reduces the vaccine’s content from the full-length SARS-CoV-2 spike protein to a narrowly focused encoding of just two segments—the N-terminal domain (NTD) and the receptor binding domain (RBD).
Some of the highlights of the new formula include:
- Improved antigen expression: mRNA-1283 demonstrated improved antigen expression compared to the clinically available mRNA-1273, which encodes the full-length spike protein. This suggests that mRNA-1283 can produce higher levels of the target antigens.
- Enhanced antibody responses: When administered as a primary series, booster, or variant-specific booster, mRNA-1283 elicited similar or greater immune responses than the original mRNA-1273.
- Greater stability: mRNA-1283 showed greater stability at refrigerated temperatures (2° to 8°C). Specifically, mRNA-1283 reached 62% of its initial integrity at 12 months when stored at 2° to 8°C, while the original version reached 63% integrity after only six months under the same conditions, effectively doubling the shelf life.
- Dose-sparing: mRNA-1283 demonstrated the ability to elicit effective immunogenic responses even at lower doses, suggesting the possibility of dose-sparing, which could reduce potential reactogenicity.
- Protection against variants: mRNA-1283, including variant-specific versions, produced more significant neutralizing antibody (nAb) responses against variants such as B.1.351 and B.1.617.2 compared to mRNA-1273, indicating its effectiveness against emerging variants.
Protection in animal models
In animal studies, mice vaccinated with mRNA-1283 were protected from both the D614G mutation and BA.1 variants of SARS-CoV-2, further suggesting that mRNA-1283 can confer protection against different strains of the virus.
Overall, mRNA-1283 offers several advantages, including improved antigen expression, strong immune responses, stability, and dose-sparing, making it a promising candidate for further clinical evaluation as a COVID-19 vaccine.
Early research on the SARS-CoV-2 virus identified the spike protein as a critical component of viral entry into host cells. This knowledge laid the foundation for the original vaccine development by Moderna, which encoded the entire length of the spike protein in the original vaccine formulation.
Researchers have since recognized that not all parts of the spike protein are equally crucial for immune responses. Certain regions, particularly the receptor binding domain (RBD) and the N-terminal domain (NTD), were identified as critical sites for neutralization by antibodies.
Extensive research into the structure and function of the SARS-CoV-2 virus, including its spike protein, provided valuable insights into potential vaccine targets. Scientists used this research to design vaccines specifically focused on the RBD, NTD, or a combination of these domains.
A combination of a deep understanding of the virus, advances in vaccine technology, and rigorous scientific research contributed to the discovery that domain-based vaccines like mRNA-1283 can focus on just the critical antigenic domains of the spike protein.
An effective streamlined and targeted vaccine should also allow for a shorter response time to emerging strains as reformulation efforts only need to focus on the changes of two sites on the virus spike protein.
More information: Guillaume B. E. Stewart-Jones et al, Domain-based mRNA vaccines encoding spike protein N-terminal and receptor binding domains confer protection against SARS-CoV-2, Science Translational Medicine (2023). DOI: 10.1126/scitranslmed.adf4100
News
How the FDA opens the door to risky chemicals in America’s food supply
Lining the shelves of American supermarkets are food products with chemicals linked to health concerns. To a great extent, the FDA allows food companies to determine for themselves whether their ingredients and additives are [...]
Superbug crisis could get worse, killing nearly 40 million people by 2050
The number of lives lost around the world due to infections that are resistant to the medications intended to treat them could increase nearly 70% by 2050, a new study projects, further showing the [...]
How Can Nanomaterials Be Programmed for Different Applications?
Nanomaterials are no longer just small—they are becoming smart. Across fields like medicine, electronics, energy, and materials science, researchers are now programming nanomaterials to behave in intentional, responsive ways. These advanced materials are designed [...]
Microplastics Are Invading Our Arteries, and It Could Be Increasing Your Risk of Stroke
Higher levels of micronanoplastics were found in carotid artery plaque, especially in people with stroke symptoms, suggesting a potential new risk factor. People with plaque buildup in the arteries of their neck have been [...]
Gene-editing therapy shows early success in fighting advanced gastrointestinal cancers
Researchers at the University of Minnesota have completed a first-in-human clinical trial testing a CRISPR/Cas9 gene-editing technique to help the immune system fight advanced gastrointestinal (GI) cancers. The results, recently published in The Lancet Oncology, show encouraging [...]
Engineered extracellular vesicles facilitate delivery of advanced medicines
Graphic abstract of the development of VEDIC and VFIC systems for high efficiency intracellular protein delivery in vitro and in vivo. Credit: Nature Communications (2025). DOI: 10.1038/s41467-025-59377-y. https://www.nature.com/articles/s41467-025-59377-y Researchers at Karolinska Institutet have developed a technique [...]
Brain-computer interface allows paralyzed users to customize their sense of touch
University of Pittsburgh School of Medicine scientists are one step closer to developing a brain-computer interface, or BCI, that allows people with tetraplegia to restore their lost sense of touch. While exploring a digitally [...]
Scientists Flip a Gut Virus “Kill Switch” – Expose a Hidden Threat in Antibiotic Treatment
Scientists have long known that bacteriophages, viruses that infect bacteria, live in our gut, but exactly what they do has remained elusive. Researchers developed a clever mouse model that can temporarily eliminate these phages [...]
Enhanced Antibacterial Polylactic Acid-Curcumin Nanofibers for Wound Dressing
Background Wound healing is a complex physiological process that can be compromised by infection and impaired tissue regeneration. Conventional dressings, typically made from natural fibers such as cotton or linen, offer limited functionality. Nanofiber [...]
Global Nanomaterial Regulation: A Country-by-Country Comparison
Nanomaterials are materials with at least one dimension smaller than 100 nanometres (about 100,000 times thinner than a human hair). Because of their tiny size, they have unique properties that can be useful in [...]
Pandemic Potential: Scientists Discover 3 Hotspots of Deadly Emerging Disease in the US
Virginia Tech researchers discovered six new rodent carriers of hantavirus and identified U.S. hotspots, highlighting the virus’s adaptability and the impact of climate and ecology on its spread. Hantavirus recently drew public attention following reports [...]
Studies detail high rates of long COVID among healthcare, dental workers
Researchers have estimated approximately 8% of Americas have ever experienced long COVID, or lasting symptoms, following an acute COVID-19 infection. Now two recent international studies suggest that the percentage is much higher among healthcare workers [...]
Melting Arctic Ice May Unleash Ancient Deadly Diseases, Scientists Warn
Melting Arctic ice increases human and animal interactions, raising the risk of infectious disease spread. Researchers urge early intervention and surveillance. Climate change is opening new pathways for the spread of infectious diseases such [...]
Scientists May Have Found a Secret Weapon To Stop Pancreatic Cancer Before It Starts
Researchers at Cold Spring Harbor Laboratory have found that blocking the FGFR2 and EGFR genes can stop early-stage pancreatic cancer from progressing, offering a promising path toward prevention. Pancreatic cancer is expected to become [...]
Breakthrough Drug Restores Vision: Researchers Successfully Reverse Retinal Damage
Blocking the PROX1 protein allowed KAIST researchers to regenerate damaged retinas and restore vision in mice. Vision is one of the most important human senses, yet more than 300 million people around the world are at [...]
Differentiating cancerous and healthy cells through motion analysis
Researchers from Tokyo Metropolitan University have found that the motion of unlabeled cells can be used to tell whether they are cancerous or healthy. They observed malignant fibrosarcoma [...]
