A new study led by Massachusetts General Hospital (MGH) investigators finds that radiation therapy may increase the uptake of therapeutic nanoparticles by glioblastomas, raising the possibility of using both growth-factor-targeted and immune-system-based therapies against the deadly brain tumor. The team describes how pretreatment with low-dose radiation increased delivery to tumors of nanoparticles carrying small interfering RNA (siRNA) molecules and significantly improved survival in a mouse model of glioblastoma.
“We found that radiation therapy primes brain tumors for enhanced uptake of nanotherapeutics, allowing us to develop a targeted nanoparticle to deliver siRNAs for both immune checkpoint and targeted therapy against the most aggressive type of brain tumor,” says Bakhos Tannous, PhD, of the Neuro-Oncology Division in the MGH Department of Neurology, senior author of the report published in ACS Nano. “A brief burst of radiation was able to increase uptake of the nanoparticle up to five-fold, enhancing the effects of targeted therapy, activating the immune response at the tumor site and prolonging survival.”
While up to 60 percent of glioblastomas express the EGFR growth factor, a molecule used in targeted therapies against several types of cancer, EGFR-targeted therapies have had little success against the brain tumors. Similarly immunotherapies directed against immune checkpoints such as CTLA-4 and PD-L1 have promising results against many cancers but not yet against glioblastoma. Some studies have suggested an association between EGFR activation and increased PD-L1 expression, raising the possibility that targeted both could increase the antitumor effects.
In order to deliver siRNAs targeting both EGFR and PD-L1 to brain tumors, the researchers developed a solid lipid nanoparticle guided by a tumor-targeting peptide called iRGD, which binds to a molecule present on blood vessels lining the tumor, allowing it to penetrate both the blood-brain and blood-tumor barriers. Factors such as the small size and positive charge of this nanoparticle allow it to penetrate the blood-brain barrier; and like other solid lipid nanoparticles, its low cost, stability, biodegradability and ease of manufacture make it an attractive option, explains Gulsah Erel-Akba, PhD, of MGH Neuro-Oncology and Izmir Katip Celebi University in Turkey, the first author of the study.
Image Credit: massgeneral.org
News This Week
It's called the "stealth" variant, but there's nothing particularly stealthy about it. Researchers are working to parse whether it is a new threat. As coronavirus case numbers in the U.S. show early signs of [...]
A group of researchers proposed an optimized electroforming strategy to achieve a bioinspired nano-holed TiO2 coated Ti6Al4V alloy, according to a study published in the journal ACS Applied Material Interfaces. Near-infrared (NIR) energy plays a critical part [...]
The Centers for Disease Control and Prevention estimates that more than 2.8 million Americans experience antibiotic-resistant infections each year; more than 35,000 die from those infections. To address this critical and worldwide public health [...]
Scientists at The University of Texas MD Anderson Cancer Center and Northwestern Medicine have identified natural extracellular vesicles containing the ACE2 protein (evACE2) in the blood of COVID-19 patients that can block infection from [...]
Scientists at Northwestern Medicine and The University of Texas MD Anderson Cancer Center have identified natural nano-bubbles containing the ACE2 protein (evACE2) in the blood of COVID-19 patients and discovered these nano-sized particles can [...]
Pioneering Artificial Intelligence (AI) technology, developed by experts at University of the West of Scotland (UWS), is capable of accurately diagnosing Covid-19 in just a few minutes. The groundbreaking program is able to detect [...]
Antimicrobial resistance poses a significant threat to humanity, health leaders have warned, as a study reveals it has become a leading cause of death worldwide and is killing about 3,500 people every day. More [...]
The Necessity of Novel Antiviral Materials With the severe acute respiratory coronavirus 2 (SARS-CoV-2) being highly infectious and transmissible, the need for novel antiviral materials that can decrease viral activities has become paramount. Preparation procedures [...]
Individuals living with Type 1 diabetes must carefully follow prescribed insulin regimens every day, receiving injections of the hormone via syringe, insulin pump or some other device. And without viable long-term treatments, this course [...]
Researchers from the University of Sydney Nano Institute and School of Chemistry have revealed that tiny gas bubbles – nanobubbles just 100 billionths of a metre high – form on surfaces in unexpected situations, [...]
Innovative researchers have investigated the potential of incorporating a gelatin methacryloyl hydrogel functionalized with synthetic nanoclay laponite to improve the delivery of osteoblast derived extracellular vesicles for increased bone repair. This research has been [...]
A couple of essential biomolecules play a key role in the process of blood clotting. One of these is a protein called fibrinogen. It is often given to those who have experienced heavy bleeding, [...]
Nanoemulsions are a relatively new technology that has found significant use for delivering functional chemicals such as micronutrients, flavorings, bioactive molecules, and antimicrobial agents into food and beverage products. This article focuses on applying [...]
Researchers at Penn Medicine have discovered a new, more effective method of preventing the body's own proteins from treating nanomedicines like foreign invaders, by covering the nanoparticles with a coating to suppress the immune [...]
Bioinspired by tunicates and mussels, a Korean research team has created a “bomb-like” anticancer therapeutic agent that only destroys cancer cells. Schematic diagram of the mechanism of action of photoactivatable adhesive nanobombs made with [...]