November 14, 2022 — Researchers at the University of Texas MD Anderson Cancer Center have developed a nanotechnology platform that changes the immune system’s perception of solid tumor cells, making them more receptive to immunotherapy.
Immunotherapy can work well for blood cancers but has less success on solid tumors. The signaling lymphocytic activation molecule family member 7 (SLAMF7) receptor is critical in activating the body’s immune cells against cancer cells via an “eat me” signal. This receptor is found on blood cancer cell surfaces but not on solid tumor cells, making it a target for the researchers’ immune conversion approach.
To promote SLAMF7 expression on solid tumor cells, the researchers developed their bispecific tumor-transforming nanoconjugate (BiTN) platform. One molecule on this nanosystem binds to the targeted tumor cell surface; a second molecule activates an immune response.
The research team used BiTN with SLAMF7 and a HER2-recognizing antibody to target HER2-positive breast cancer cells. The nanoconjugate successfully attached SLAMF7 to the breast cancer cells, resulting in phagocytosis, or ingestion, by immune cells. The approach also sensitized breast cancer cells to an anti-CD47 antibody treatment, which blocks “don’t eat me” signals from tumor cells, further increasing solid tumor response. This adaptable immune conversion approach may have broad applications across many cancers.
“If we are able to translate and validate this approach in the clinic, it may enable us to get closer to the maximum level of activity from immunotherapy drugs with cancers that have not traditionally responded well,” co-author Dr. Wen Jiang, PhD, assistant professor of radiation oncology at the MD Anderson Cancer Center, said in a statement.
Omicron subvariant BA.2 – which was dominant worldwide early this year, including in Hong Kong – replicates more swiftly than other strains and causes faster programmed cell death in human brains, a new study has found. [...]
The urgent need to remove excess carbon dioxide from Earth’s environment could include enlisting some of our planet’s smallest inhabitants, according to an international research team led by Michael Hochella of the Department of [...]
Blood pressure is a key vital sign that provides insight into our cardiovascular health. But blood pressure is typically measured only a few times per year by a clinician—and these measurements might not always [...]
A South African laboratory study using Covid-19 samples from an immunosupressed individual over six months showed that the virus evolved to become more pathogenic, indicating that a new variant could cause worse illness than [...]
For the past several months, Omicron subvariants BA.4 and BA.5 have dominated COVID-19 cases in the U.S. But now, there’s a class of new COVID subvariants on the rise and one in particular is getting plenty of [...]
Nucleic acid therapies involving DNA or RNA have significant potential to treat genetic disorders, infectious diseases, and cancer; however, research suggests that less than 1% of injected nucleic acid doses reach target cells in [...]
The US Food and Drug Administration on Tuesday approved Hemgenix, a new drug to treat hemophilia. Manufacturer CSL Behring set the price at $3.5 million per treatment, making it the most expensive drug [...]
Some wounds just won’t heal. Infections, diseases like diabetes, and suppressed immune systems often stack up to slow healing. Chronic wounds can last months and lead to anxiety and depression. In the worst cases, [...]
Over the years, researchers have tried hard to comprehend topographic signals that promote cell mechanical sensitive responses. The extracellular matrix (ECM) provides a complex cellular microenvironment that controls cellular behavior. Nevertheless, only a few [...]
There is now an imminent threat of measles spreading in various regions globally, as COVID-19 led to a steady decline in vaccination coverage and weakened surveillance of the disease, the World Health Organization (WHO) [...]
In a recent study, it was shown that people with long Covid have had physical changes to their brains several months after experiencing the initial infection. The study included MRIs of patients who continued [...]
Western University in London, Ont., is building a unique research lab to study humanity's greatest viral threats — a secret weapon, if you will, one that it's expected would put Canada and the world in a better position if [...]
Cancer patients are testing a medicine made of antibodies that were designed from scratch on a computer in Israel and whose inventor has “programmed” them to “decide” whether cells surrounding tumors are bad or good. [...]
In an article published in the journal Scientific Reports, researchers presented the potentiostatic deposition used to electrodeposit nickel (Ni) and nickel-graphene (Ni-G) films on copper substrates. Myristic acid (MA) was employed to alter the plane of the [...]
Oregon State University scientists have invented a way to make magnetic nanoparticles that get hotter than any previous nanoparticle, improving their cancer fighting ability. Faculty from the OSU College of Pharmacy spearheaded a collaboration [...]