In humans and other multicellular organisms, cells multiply. This defining feature allows embryos to grow into adulthood, and enables the healing of the many bumps, bruises and scrapes along the way.
Certain factors can cause cells to abandon this characteristic and enter a zombie-like state known as senescence where they persist but no longer divide to make new cells. Our bodies can remove these senescent cells that tend to pile up as we age. The older we get, however, the less efficient our immune systems become at doing so.
“In addition to no longer growing and proliferating, the other hallmark of senescent cells is that they have this inflammatory program causing them to secrete inflammatory molecules,” said Peter Adams, Ph.D., director and professor of the Cancer Genome and Epigenetics Program at Sanford Burnham Prebys and senior and co-corresponding author of the study.
Cells “running” this inflammatory program are considered to exhibit the senescence-associated secretory phenotype (SASP). Too many cells with SASP secreting inflammatory molecules can contribute to chronic inflammation in the body. This pervasive inflammation—called “inflammaging”—has been linked to many age-related diseases.
Scientists at Sanford Burnham Prebys and collaborators across the country published findings in Nature Communications showing that the mitochondria powering our cells also control the ability of a DNA repair protein to suppress SASP, which may reduce or delay inflammaging.
The research team turned human cells senescent by exposing them to radiation and then used those cells to demonstrate that DNA fixer tumor protein p53 suppressed SASP and one of its triggering events, the formation of cytoplasmic chromatin fragments (CCF).
These fragments are bits of damaged DNA that have been spewed from the cells’ nuclei into the gel-like cytoplasm that occupies the space in the cell between the outer membrane and central nucleus. The presence of DNA where it does not belong can trigger the immune system and contribute to SASP.
The scientists validated their findings in mice by treating them with a drug developed by cancer researchers to activate p53 as a way of suppressing tumors. In aged mice, the drug did not reduce the number of senescent cells but instead reversed the cellular signature that marks age-associated SASP, potentially stopping the inflammatory pollution that can lead to inflammaging.
In addition, the investigators discovered that senescent cells suffer from dysfunction in the mitochondria, serving as cells’ primary source of energy. Stressed mitochondria can cause senescent cells to form CCF and dampen the expression of the gene carrying the blueprint for p53.
“Altogether, we’ve identified a cellular circuit capable of promoting DNA repair and genome integrity while suppressing the dangerous inflammatory feature of senescent cells that contribute to age-related diseases,” said Karl Miller, Ph.D., staff scientist in the Adams lab at Sanford Burnham Prebys and lead and co-corresponding author of the study.
“We also have shown that this pathway can be modified by existing drugs in cultured cells and mice, so it may be possible to one day design a treatment that targets p53 to promote healthier aging.”
More information: Karl N. Miller et al, p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells, Nature Communications (2025). DOI: 10.1038/s41467-025-57229-3
News
Scientists Identify “Good” Bacteria That May Prevent Long COVID
According to the WHO, about 6% of people worldwide who get COVID-19, roughly 400 million people, later develop a long-lasting form of the illness. That shows the condition remains a significant public health challenge. In [...]
New book from Nanoappsmedical Inc. – Global Health Care Equivalency
A new book by Frank Boehm, NanoappsMedical Inc. Founder. This groundbreaking volume explores the vision of a Global Health Care Equivalency (GHCE) system powered by artificial intelligence and quantum computing technologies, operating on secure [...]
RNA Recycling Extends Lifespan
Summary: Researchers discovered a biological “trash disposal” mechanism that directly controls how fast we age. While circular RNA has long been known to accumulate in cells as we get older, this study proves for the [...]
Cancer’s Deadly Paradox: How Tumors Break Their Own DNA To Keep Growing
Cancer’s strongest gene switches push DNA into damaging overdrive, creating repeated breaks and repairs that may fuel tumor evolution while exposing possible therapeutic weak spots. A new study indicates that cancer can harm its own genetic [...]
NanoMedical Brain/Cloud Interface – Explorations and Implications. A new book from Frank Boehm
New book from Frank Boehm, NanoappsMedical Inc Founder: This book explores the future hypothetical possibility that the cerebral cortex of the human brain might be seamlessly, safely, and securely connected with the Cloud via [...]
Our books now available worldwide!
Online Sellers other than Amazon, Routledge, and IOPP Indigo Global Health Care Equivalency in the Age of Nanotechnology, Nanomedicine and Artifcial Intelligence Global Health Care Equivalency In The Age Of Nanotechnology, Nanomedicine And Artificial [...]
Ryugu asteroid samples contain all DNA and RNA building blocks, bolstering origin-of-life theories
All the essential ingredients to make the DNA and RNA underpinning life on Earth have been discovered in samples collected from the asteroid Ryugu, scientists said Monday. The discovery comes after these building blocks [...]
Is Berberine Really a “Natural Ozempic”?
Often labeled a “natural Ozempic,” berberine is widely discussed as a metabolic aid. Yet research suggests its influence may lie deeper. In recent years, berberine has gained significant attention as a supposed “natural way” [...]
Viagra Ingredient Shows Promise for Rare Childhood Brain Disease in Surprising Study
A rare childhood disease with no approved treatment may have an unexpected new therapeutic candidate. Sildenafil, the active ingredient also sold under the brand name Viagra, may help reduce symptoms in people with Leigh [...]
In a first for China, Neuracle’s implantable brain-computer interface wins approval
In a landmark development, Neuracle Medical Technology has secured the country’s first-ever approval for an implantable brain-computer interface (BCI) system designed to restore hand motor function in patients with spinal cord injuries, in a [...]
A Cambridge Lab Mistake Reveals a Powerful New Way to Modify Drug Molecules
A surprising lab discovery reveals a light-powered way to tweak complex drugs faster, cleaner, and later in development. Researchers at the University of Cambridge have created a new technique for altering complex drug molecules [...]
New book from NanoappsMedical Inc – Molecular Manufacturing: The Future of Nanomedicine
This book explores the revolutionary potential of atomically precise manufacturing technologies to transform global healthcare, as well as practically every other sector across society. This forward-thinking volume examines how envisaged Factory@Home systems might enable the cost-effective [...]
Scientists Discover Simple Saliva Test That Reveals Hidden Diabetes Risk
Researchers have identified a potential new way to assess metabolic health using saliva instead of blood. High insulin levels in the blood, known as hyperinsulinemia, can reveal metabolic problems long before obvious symptoms appear. It is [...]
One Nasal Spray Could Protect Against COVID, Flu, Pneumonia, and More
A single nasal spray vaccine may one day protect against viruses, pneumonia, and even allergies. For decades, scientists have dreamed of creating a universal vaccine capable of protecting against many different pathogens. The idea [...]
New AI Model Predicts Cancer Spread With Incredible Accuracy
Scientists have developed an AI system that analyzes complex gene-expression signatures to estimate the likelihood that a tumor will spread. Why do some tumors spread throughout the body while others remain confined to their [...]
Scientists Discover DNA “Flips” That Supercharge Evolution
In Lake Malawi, hundreds of species of cichlid fish have evolved with astonishing speed, offering scientists a rare opportunity to study how biodiversity arises. Researchers have identified segments of “flipped” DNA that may allow fish to adapt rapidly [...]
