Researchers from the Netherlands Institute for Neuroscience (NIN) and the Leiden University Medical Center (LUMC) have shown that treatment using gene therapy leads to a faster recovery after nerve damage. By combining a surgical repair procedure with gene therapy, the survival of nerve cells and regeneration of nerve fibers over a long distance was stimulated for the first time. The discovery, published in the journal Brain, is an important step towards the development of a new treatment for people with nerve damage.
During birth or following a traffic accident, nerves in the neck can be torn out of the spinal cord. As a result, these patients lose their arm function, and are unable to perform daily activities such as drinking a cup of coffee. Currently, surgical repair is the only available treatment for patients suffering this kind of nerve damage. “After surgery, nerve fibers have to bridge many centimeters before reaching the muscles and nerve cells from which new fibers need to regenerate are lost in large numbers. Most regenerating nerve fiber do not reach the muscles. The recovery of arm function is therefore disappointing and incomplete,” explains researcher Ruben Eggers of the NIN.
Combination of treatments
By combining neurosurgical repair with gene therapy in rats, many of the dying nerve cells can be rescued and nerve fiber growth in the direction of the muscle can be stimulated.
In this study, the researchers used regulatable gene therapy with a growth factor that could be switched on and off by using a widely used antibiotic. “Because we were able to switch off the gene therapy when the growth factor was no longer needed, the regeneration of new nerve fibers towards the muscles was improved considerably,” says Ruben Eggers.
A stealth gene switch
To overcome the problem of the immune system recognizing and removing the gene switch, the researchers developed a hidden version, a so-called ‘stealth switch’. Professor Joost Verhaagen (NIN) explains: “The stealth gene switch is an important step forward towards the development of gene therapy for nerve damage. The use of a stealth switch improves the gene therapy rendering it even safer.”
Image Credit: NeuroscienceNews.com image is in the public domain
Thanks to Heinz V. Hoenen. Follow him on twitter: @HeinzVHoenen
News This Week
Lightning sparks scientists’ design of ultraviolet-C device for food sanitization
Scientists at the University of Illinois Urbana-Champaign have developed a portable, self-powered ultraviolet-C device called the Tribo-sanitizer that can inactivate two of the bacteria responsible for many foodborne illnesses and deaths. The Tribo-sanitizer's UVC [...]
3D Eye Scans Emerge as a Crucial Tool in Combating Kidney Disease
A new study indicates that 3D retinal scans could revolutionize the early detection and monitoring of kidney disease, offering a non-invasive and efficient diagnostic tool. 3D eye scans can reveal vital clues about kidney [...]
Researchers develop a blood test to identify individuals at risk of developing Parkinson’s disease
Research carried out at Oxford's Nuffield Department of Clinical Neurosciences has led to the development of a new blood-based test to identify the pathology that triggers Parkinson's disease before the main symptoms occur. This [...]
“Challenging the Paradigm” – Scientists Develop New Approach To Stop Cancer Growth
Biochemists at Case Western Reserve are concentrating on the degradation of a key protein that drives cancer; represents a major shift in research. Biochemical researchers at Case Western Reserve University have discovered a a new function [...]
Researcher develops a chatbot with an expertise in nanomaterials
A researcher has just finished writing a scientific paper. She knows her work could benefit from another perspective. Did she overlook something? Or perhaps there's an application of her research she hadn't thought of. [...]
Research shows human behavior guided by fast changes in dopamine levels
What happens in the human brain when we learn from positive and negative experiences? To help answer that question and better understand decision-making and human behavior, scientists are studying dopamine. Dopamine is a neurotransmitter [...]
Tiny robots made from human cells heal damaged tissue
The ‘anthrobots’ were able to repair a scratch in a layer of neurons in the lab. Scientists have developed tiny robots made of human cells that are able to repair damaged neural tissue1. The [...]
Antimicrobial Resistance – A Global Concern
Key facts Antimicrobial resistance (AMR) is one of the top global public health and development threats. It is estimated that bacterial AMR was directly responsible for 1.27 million global deaths in 2019 and contributed to [...]
Advancing Pancreatic Cancer Treatment with Nanoparticle-Based Chemotherapy
Pancreatic cancer, a particularly lethal form of cancer and the fourth leading cause of cancer-related deaths in the western world, often remains undiagnosed until its advanced stages due to a lack of early symptoms. [...]
The ‘jigglings and wigglings of atoms’ reveal key aspects of COVID-19 virulence evolution
Richard Feynman famously stated, "Everything that living things do can be understood in terms of the jigglings and wigglings of atoms." This week, Nature Nanotechnology features a study that sheds new light on the evolution of the coronavirus [...]
AI system self-organizes to develop features of brains of complex organisms
Cambridge scientists have shown that placing physical constraints on an artificially-intelligent system—in much the same way that the human brain has to develop and operate within physical and biological constraints—allows it to develop features [...]
How Blind People Recognize Faces via Sound
Summary: A new study reveals that people who are blind can recognize faces using auditory patterns processed by the fusiform face area, a brain region crucial for face processing in sighted individuals. The study employed [...]
Treating tumors with engineered dendritic cells
Cancer biologists at EPFL, UNIGE, and the German Cancer Research Center (Heidelberg) have developed a novel immunotherapy that does not require knowledge of a tumor's antigenic makeup. The new results may pave the way [...]
Networking nano-biosensors for wireless communication in the blood
Biological computing machines, such as micro and nano-implants that can collect important information inside the human body, are transforming medicine. Yet, networking them for communication has proven challenging. Now, a global team, including EPFL [...]
Popular Hospital Disinfectant Ineffective Against Common Superbug
Research conducted during World Antimicrobial Awareness Week examines the effects of employing suggested chlorine-based chemicals to combat Clostridioides difficile, the leading cause of antibiotic-related illness in healthcare environments worldwide. A recent study reveals that a [...]
Subjectivity and the Evolution of AI Philosophy
An Historical Overview of the Philosophy of Artificial Intelligence by Anton Vokrug Many famous people in the philosophy of technology have tried to comprehend the essence of technology and link it to society and human [...]
Leave A Comment