In a potential game changer for COVID-19 pandemic control efforts, a new cell phone app and lab kit have transformed a smartphone into a COVID-19 / flu detection system. The detection system is among the most rapid, sensitive, affordable and scalable tests known—and can be readily adapted for other pathogens with pandemic potential including deadly variants of COVID and flu. It also provides a platform for inexpensive home-based testing.
The project was led by professors Michael Mahan, David Low and Charles Samuel of UC Santa Barbara, along with Santa Barbara Cottage Hospital physicians Jeffrey Fried, M.D. and Lynn Fitzgibbons, M.D. Additional collaborators include UCSB scientists Douglas Heithoff, Lucien Barnes, Scott Mahan and Gary Fox—as well as Cottage Hospital scientists Katherine Arn, M.D., Andrew Bishop, M.D., and Sarah Ettinger, M.D.
“As new COVID variants emerge globally, testing and detection remain essential to pandemic control efforts,” lead author Michael Mahan said. “Nearly half the world’s population has a smartphone, and we believe that this holds exciting potential to provide fair and equal access to precision diagnostic medicine.”
The collaboration was launched to develop rapid, low-cost diagnostics that can be used by healthcare providers anywhere in the world to diagnose COVID-19. The lab kit can be produced for less than $100, and it requires little more than a smartphone, a hot plate and LED lights. The screening tests can be run for less than $7 each versus $10 to $20 per rapid antigen test and $100 to $150 per PCR test.
The process, termed smaRT-LAMP, is simple and straightforward. A small volume of the patient’s saliva is collected and analyzed by the smartphone app using the phone’s camera and the diagnostic kit. No additional specialty materials are required.
PCR tests are the gold standard due to their sensitivity and accuracy, but they are slow, expensive and not portable. LAMP tests match the sensitivity and accuracy of PCR—at a fraction of the time and cost. Further, LAMP occurs at constant temperature, which is suitable for point-of-care and home-based testing.
“The key finding was solving the LAMP ‘primer-dimer’ problem—false positives due to high sensitivity—which scientists have struggled with for more than 20 years,” Heithoff explained. “It took more than 500 attempts to solve it for COVID-19, after which flu viruses were detected on the very first try.”
The simple lab test can detect and differentiate COVID-19 and the flu, which show very similar respiratory disease symptoms and can lead to misdiagnosis.
“SmaRT-LAMP can detect COVID-19 and can be readily modified to detect novel CoV-2 variants and other pathogens with pandemic potential, including influenza,” Samuel said.
“We hope technologies like this offer new ways of bringing state-of-the-art diagnostics to underserved and vulnerable populations,” Low explained.
The free, custom-built app was developed for the Android operating system and can be downloaded and installed from the Google Play Store. Upon opening the app, the user is presented with an option for a step-by-step tutorial prior to running test samples.
“Rapid and affordable testing of vulnerable populations that are struggling with adequate vaccine and testing is critically important,” explained Fitzgibbons, an infectious disease physician.
“Such early detection and quarantine can also reduce the risk of future global outbreaks,” added Fried, a critical care physician.
News
Novel Investment Paradigms for Regenerative Healthcare Ecosystems
Introduction The transition toward regenerative healthcare ecosystems—anchored in wellness optimization, disease prevention, eradication strategies, and healthy longevity—necessitates a structural reconfiguration of capital architectures, governance models, and incentive design. Regenerative healthcare, by definition, transcends episodic [...]
What If Consciousness Exists Beyond Your Brain
Scientists still don’t know how consciousness emerges from the brain. New ideas suggest it may not emerge at all, but instead be a basic feature of reality. Is consciousness produced by the brain, or [...]
Scientists Discover Way To Treat Lung Cancer and Its Deadly Side Effect Together
A new approach using lipid nanoparticles to deliver genetic material is showing promise in tackling two major challenges in lung cancer at once.Researchers at Oregon State University have designed a new way to tackle two of [...]
Saunas Activate Your Immune System
A brief sauna session may quietly mobilize the immune system. A sauna session may do more than raise your heart rate and body temperature. A new study from Finland found that it also briefly [...]
Why music from your youth still has such an intense effect years later: A psychological perspective
You're driving, and suddenly a familiar song fills the air. Before you even know it, a wave of emotions comes over you – not just memories, but a deep, almost physical feeling. This powerful [...]
AI to antibody in days: breaking the wet lab bottleneck via high-throughput integration
The role of artificial intelligence (AI) in drug design has fundamentally shifted from a speculative tool to a central pillar of pharmaceutical research and development (R&D). Sino Biological plays a critical role in this [...]
Regenerative Healthcare by Design: Engineering Health-Centric Buildings and Urban Ecosystems
Introduction The next evolution of healthcare will not be confined to hospitals, clinics, or episodic interventions—it will be embedded into the infrastructure of everyday life. Regenerative health ecosystems require a systemic re-architecture of how [...]
Scientists Warn: Humanity Has Pushed the Planet Past Its Limits
Human population and consumption have surpassed Earth’s limits, increasing risks to climate and global stability. The Earth is already operating beyond its capacity to sustainably support the global population, according to new research highlighting [...]
Breakthrough Study Reveals Why Damaged Nerves Struggle To Heal
A newly identified molecular mechanism reveals how neurons weigh survival against repair after injury. Scientists at the Icahn School of Medicine at Mount Sinai have identified a molecular switch in neurons that limits the regrowth of [...]
Popular Vitamin B3 Supplements May Help Cancer Cells Survive, Scientists Warn
A new study raises important questions about widely used NAD+ supplements, suggesting that compounds often taken to boost energy and support healthy aging may have unintended consequences in cancer treatment. Millions of Americans take [...]
Scientists Discover Cancer Tumors Are “Addicted” to This Common Antioxidant
Cancer cells may be exploiting a common antioxidant as fuel, revealing a potential weakness that future therapies could target. Cancer cells may be tapping into an unexpected energy source: an antioxidant long associated with [...]
Nanotube injector transfers cytoplasmic contents and organelles between living cells safely
Cells are not isolated units; they continuously exchange proteins, genetic material, and even entire organelles with their neighbors. Intercellular transfer influences how tissues develop, respond to stress, and repair damage. In certain cancers, for [...]
CEO of America’s largest public hospital system is ready to replace radiologists with AI
The chief executive of America’s largest public hospital system says he is prepared to start replacing radiologists with artificial intelligence in some circumstances, once the regulatory landscape catches up. Mitchell H. Katz, MD, president [...]
Our books now available worldwide!
Online Sellers other than Amazon, Routledge, and IOPP Indigo Global Health Care Equivalency in the Age of Nanotechnology, Nanomedicine and Artifcial Intelligence Global Health Care Equivalency In The Age Of Nanotechnology, Nanomedicine And Artificial [...]
Study finds higher heart disease risk in long COVID patients
People with long COVID are at increased risk of developing cardiovascular disease, according to a new study from Karolinska Institutet published in eClinicalMedicine. The results show that the risk of conditions such as cardiac arrhythmias [...]
The Corona variant Cicada is here – we know that
Online and on social media, reports are piling up about a new Sars-Cov-2 variant that is currently on the rise: BA.3.2, also known as Cicada. That's what it's all about: The Omicron variant BA.3.2, [...]
