Knots are indispensable tools for such human activities as sailing, fishing and rock climbing, (not to mention, tying shoes). But tying a knot in a lacelike strand of DNA, measuring just billionths of a meter in length, requires patience and highly specialized expertise.
Hao Yan, a researcher at ASU, is a practiced hand in this delicate and exotic field, operating at the crossroads of nanotechnology and fine art.
In new research appearing in the journal Nature Communications, Yan and his colleagues Fei Zhang, Xiaodong Qi and others describe a method for coaxing segments of single-stranded DNA into complex 2- and 3D knotted structures.
The results represent an important advance in the fast-paced field of DNA nanotechnology, in which the molecule of life is used as a structural building material for a vast array of tiny configurations. Among these are miniscule robotic devices, photonic applications, drug delivery systems, logic gates, as well as diagnostic and therapeutic applications.
“The knotted DNA structures demonstrated in this work exhibit unprecedented topological complexity, far beyond what has been achieved before using single stranded folding,” Yan says. “Indeed, it is not only amazing but also surprising that the single-stranded DNA and RNA can thread through its own chains and find a way to form such highly knotted structures, given the fact that the single strand has to weave through so many tangles.”
Yan directs the Biodesign Center for Molecular Design and Biomimetics and is the Martin D. Glick Distinguished Professor in the School of Molecular Sciences at ASU.
Image Credit: Biodesign Institute
News This Week
A Brazilian study published in the journal PNAS describes some of the effects infection by SARS-CoV-2 can have on the central nervous system. A preliminary version (not yet peer-reviewed) posted in 2020 was one of the [...]
A new drug designed by scientists at Scripps Research can turn the COVID-19 virus into a harbinger of its own doom. The drug, NMT5, described in Nature Chemical Biology on September 29, 2022, coats SARS-CoV-2 with [...]
Brain stimulation paired with a nose spray comprised of nanoparticles can increase recovery after ischemic stroke in an animal model, according to scientists from Xi’an Jiaotong-Liverpool University and other universities in China. The nasal spray is [...]
Increasing drug resistance could leave us powerless to fight infections we now consider routine, and scientists are urgently searching for answers. It was just a urinary tract infection (UTI). Helen Osment, a fundraiser from Hertfordshire, had [...]
Daegu Gyeongbuk Institute of Science & Technology (DGIST, President Yang Kook) Professor Hongsoo Choi’s team of the Department of Robotics and Mechatronics Engineering collaborated with Professor Sung-Won Kim’s team at Seoul St. Mary’s Hospital, [...]
Tiny nets woven from DNA strands can ensnare the spike protein of the virus that causes COVID-19, lighting up the virus for a fast-yet-sensitive diagnostic test—and also impeding the virus from infecting cells, opening [...]
Roughly two decades ago, a strategy called optogenetics emerged to control brain activity with lasers. It uses viruses to insert genes into cells that make them sensitive to light. Optogenetics has revolutionized neuroscience by giving researchers [...]
Shigella bacteria, which causes Shigellosis, is the primary cause of bacterial diarrhea and diarrheal death among juveniles under five years of age. Because of the antibiotic resistance of Shigella strains, no commercial vaccines are available to date. [...]
Scientists have built microscopic robots equipped with electronic “brains” that are capable of walking autonomously. A team from Cornell University in the US developed the solar-powered bots as part of research into a new generation of [...]
Blood samples from patients with long COVID who are still suffering from fatigue and shortness of breath after a year show signs of autoimmune disease, according to a study published today (Thursday) [...]
High-grade serous ovarian cancer (HGSOC) is among the deadliest human cancers and its prognosis remains extremely poor. An article published in Advanced Science explored the self-therapeutic properties of gold nanoparticles to identify a molecular axis that [...]
Antimicrobial peptides (AMPs) have a broad spectrum of antimicrobial activity and lyse microbial cells by interaction with biomembranes, offering great potential in designing new therapeutics. The antimicrobial resistance (AMR) caused due to overuse of [...]
Tumor cells are notoriously good at evading the human immune system; they put up physical walls, wear disguises and handcuff the immune system with molecular tricks. Now, UC San Francisco researchers have developed a [...]
Hyperspectral microscopy is an advanced visualization technique that combines hyperspectral imaging with state-of-the-art optics and computer software to enable rapid identification of nanomaterials. Since hyperspectral datacubes are large, their acquisition is complicated and time-consuming. [...]
Malignant brain tumors are cancerous growth in the brain with the possibility of spreading to other parts of the central nervous system (CNS). Brain tumors are highly invasive and have devastating consequences, poor prognosis, [...]
An ultrathin invention could make future computing, sensing and encryption technologies remarkably smaller and more powerful by helping scientists control a strange but useful phenomenon of quantum mechanics, according to new research recently published [...]