A nanotechnology treatment derived from bone marrow stem cells has reversed multiple sclerosis symptoms in mice and could eventually be used to help humans, according to a new study led by University of California, Irvine researchers.
“Until now, stem cell therapies for autoimmune and neurodegenerative diseases have produced mixed results in clinical trials, partly because we don’t know how the treatments work,” said corresponding author Weian Zhao, an associate professor of pharmaceutical sciences and biomedical engineering who is affiliated with the Sue & Bill Gross Stem Cell Research Center. “This study helps unravel that mystery and paves the way for testing with human patients.”
In past experiments, intravenously injected stem cells – taken from bone marrow and activated with interferon gamma, an immune system protein – often got trapped in filter organs before reaching their target. For this study, published in the journal ACS Nano, researchers avoided that problem by extracting nano-sized particles called exosomes from the stem cells and injecting them into rodents with MS.
Loaded with anti-inflammatory and neuroprotective RNA and protein molecules, the exosomes were able to slip through the blood-spinal cord barrier. In addition to rejuvenating lost motor skills and decreasing nerve damage caused by MS, they normalized the subjects’ immune systems, something conventional drugs can’t do, said study co-lead author Reza Mohammadi, a UCI doctoral candidate in materials science & engineering.
More experiments are in the pipeline…
Image Credit: Public Domain
Thanks to Heinz V. Hoenen. Follow him on twitter @HeinzVHoenen
News This Week
A research team in Hungary pinched the coronavirus with a fine needle to measure how much force it could take before popping like a balloon. It did not. The native virion of Sars-CoV-2 – a [...]
Headaches, confusion and delirium experienced by some Covid-19 patients could be the result of the coronavirus directly invading the brain, according to a study published Wednesday. The research is still preliminary – but offers several [...]
By Boris M | Published in Coronavirus During the COVID-19 pandemic, there will be a lot of information about the virus and its effects on mental health. That’s because coronavirus and the social, financial and psychological [...]
A serious illness suffered by an Oxford University coronavirus vaccine trial participant was most likely “life-threatening”, a bioethics researcher says. But that doesn’t mean the clinical trials will be scrapped. AstraZeneca and Oxford University [...]
Analysis of seven trials finds dexamethasone and hydrocortisone should be given in severe cases. Studies around the world have confirmed that steroids can save lives in the Covid-19 pandemic, leading to new recommendations from [...]
Experts say strong evidence of efficacy needed to avoid approval of inferior vaccines. The rush to immunise populations against Covid-19 could lead to the rollout of a vaccine that is not very effective and [...]
The COVID-19 pandemic has dominated the news cycle for the better part of 2020. As guidelines are continually updated to reflect changes in our understanding of how the virus spreads, it is critical people [...]
Scientists in Hong Kong have reported the first confirmed case of reinfection with the coronavirus that causes Covid-19, reportedly backed up by genetic sequences of the two episodes of the 33-year-old man’s infections in March and [...]
Could uncomfortable nasal swabs be swapped for a contactless two-second breathalyzer puff to check for Covid-19 infection? Prof. Hossam Haick thinks so. Haick, a professor of chemical engineering and nanotechnology at the Technion – [...]
The relationship between antibodies for the novel coronavirus (SARS-CoV-2) and immunity, vaccine efficacy, and spread of COVID-19 has received significant attention. Dr. Seheult is back to illustrate why T cells have received less [...]
Images Description Three individuals were admitted to the hospital (ages 46–56; to men and one woman) with a multiday history of symptoms associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and underwent [...]
Study of nose and throat reveals why people with COVID-19 may lose their sense of smell Researchers studying tissue removed from patients' noses during surgery believe they may have discovered the reason why so [...]
Researchers around the world are racing to develop a vaccine against Covid-19, with more than 170 candidate vaccines now tracked by the World Health Organization (WHO). Vaccines normally require years of testing and additional time to [...]