Immune Aspects of Biopharmaceuticals and Nanomedicines
1st Edition
Raj Bawa, Janos Szebeni, Thomas J Webster, Gerald F. Audette
The enormous advances in the immunology of biotherapeutics and nanomedicines in the past two decades have necessitated an authoritative and comprehensive reference that can be relied upon by immunologists, biomedical researchers, physicians, pharmaceutical and formulation scientists, clinicians, regulatory personnel, technology transfer officers, venture capitalists, and policy makers alike.
Table of Contents
Proteins as Medicines: The Era of Biologics
Raj Bawa, János Szebeni, Thomas J. Webster, and Gerald F. Audette
Immunological Issues with Medicines of Nano Size: The Price of Dimension Paradox
János Szebeni and Raj Bawa
Immunotherapy and Vaccines
Johanna Poecheim and Gerrit Borchard
Emerging Trends in Delivery of Novel Vaccine Formulations
Trinh Phuong Vo, Rikhav P. Gala, Thripthy Chandran, Sucheta D’Sa, and Ruhi V. Ubale
Current Understanding of Interactions between Nanoparticles and the Immune System
Marina A. Dobrovolskaia, Michael Shurin, and Anna A. Shvedova
Auto-antibodies as Biomarkers for Disease Diagnosis
Angelika Lueking, Heike Göhler, and Peter Schulz-Knappe
The Accelerated Blood Clearance Phenomenon of PEGylated Nanocarriers
Amr S. Abu Lila and Tatsuhiro Ishida
Anti-PEG Immunity Against PEGylated Therapeutics
Amr S. Abu Lila and Tatsuhiro Ishida
Complement Activation: Challenges to Nanomedicine Development
Dennis E. Hourcade, Christine T. N. Pham, and Gregory M. Lanza
Intravenous Immunoglobulin at the Borderline of Nanomedicines and Biologicals: Antithrombogenic Effect via Complement Attenuation
Milan Basta
Lessons Learned from the Porcine CARPA Model: Constant and Variable Responses to Different Nanomedicines and Administration Protocols
Rudolf Urbanics, Péter Bedőcs, and János Szebeni
Blood Cell Changes in Complement Activation-Related Pseudoallergy: Intertwining of Cellular and Humoral Interactions
Zsófia Patkó and János Szebeni
Immune Reactions in the Delivery of RNA Interference-Based Therapeutics: Mechanisms and Opportunities
Kaushik Thanki, Emily Falkenberg, Monique Gangloff, and Camilla Foged
Lipid Nanoparticles Technology Induced Immunomodulatory Effects of siRNA
Ranjita Shegokar and Prabhat Mishra
Nanovaccines against Intracellular Pathogens Using Coxiella burnetii as a Model Organism
Erin J. van Schaik, Anthony E. Gregory, Gerald F. Audette, and James E. Samuel
Immunogenicity Assessment for Therapeutic Protein Products
FDA
Assay Development and Validation for Immunogenicity Testing of Therapeutic Protein Products: Guidance for Industry
FDA
The “Sentinel”: A Nanomedical Strategy for Radical Immune System Enhancement
Frank Boehm and Angelika Domschke
Immunotherapy for Gliomas and Other Intracranial Malignancies
Mario Ganau, Gianfranco K. I. Ligarotti, Salvatore Chibbaro, and Andrea Soddu
Liposome-Induced Complement Activation-Related Pseudoallergy
Amr S. Abu Lila, Janos Szebeni, and Tatsuhiro Ishida
Available now at CRC Press
Image Credit: Alias Studio Sydney
News This Week
New material discovery could revolutionize roll-out of global vaccinations
New raw vaccine materials that could make vaccines more accessible, sustainable, and ethical have been discovered. The results of the research have been published in Polymers. Adjuvants are vaccine ingredients that boost a person's immune response [...]
Scientists Develop Incredibly Lightweight Material 4 Times Stronger Than Steel
Researchers developed a light yet strong material by combining two unexpected ingredients—DNA and glass. Working at the nanoscale provides scientists with a deep understanding and precision in crafting and analyzing materials. In broader-scale production, and even [...]
New Implant Doctors Hope Will Cut Cancer Deaths in Half
Researchers at Houston's Rice University are developing an implant that could diminish deaths caused by cancer by half. The device will contain synthetically nurtured human cells and be embedded with sensors to keep track of cancer [...]
Machine learning helps predict drugs’ favorite subcellular haunts
Most drugs are small molecules that bind firmly to a specific target—some molecule in human cells that is involved in a disease—in order to work. For example, a cancer drug's target might be a [...]
Nanotechnology Breakthrough Could Help Treat Blindness
Scientists utilize nanotechnology to address a prevalent cause of vision loss. Scientists have discovered a way to use nanotechnology to create a 3D ‘scaffold’ to grow cells from the retina. This breakthrough could lead [...]
Decoding Women’s Health: Artificial Intelligence Revolutionizes PCOS Diagnosis
NIH study reviews 25 years of data and finds AI/ML can detect common hormone disorder. Artificial intelligence (AI) and machine learning (ML) can effectively detect and diagnose Polycystic Ovary Syndrome (PCOS), which is the most common [...]
Surprising Discovery Could Explain How Coronaviruses Jump Species
New insights are enhancing scientists’ efforts to stay ahead of COVID-19 and the next pandemic. Unexpected new insights into the ways COVID-19 infects cells could shed light on the virus’s adept ability to jump from one species to another [...]
A blood test for long Covid is possible, a study suggests
Scientists can now show key differences in the blood of those who recover from Covid — and those who don't. More than three years into the pandemic, the millions of people who have suffered [...]
FedEx for your cells: this biological delivery service could treat disease
Researchers want to know why cells produce tiny packages called vesicles — and whether these bundles could be used for therapy. Graça Raposo was a young postdoc in the Netherlands in 1996 when she [...]
New study on the genetic magnetization of living bacteria shows great potential for biomedicine
Magnetic bacteria possess extraordinary capabilities due to the magnetic nanoparticles, the magnetosomes, which are concatenated inside their cells. A research team at the University of Bayreuth has now transferred all of the approximately 30 [...]
Ultrathin Nanotech Promises to Help Tackle Antibiotic Resistance
Researchers have invented a nano-thin superbug-slaying material that could one day be integrated into wound dressings and implants to prevent or heal bacterial infections. The innovation – which has undergone advanced pre-clinical trials – [...]
Researchers Discover New Mnemomic Networks in the Brain
The medial temporal lobe (MTL) houses the human memory system. Broadly, it contains the hippocampus, parahippocampal cortex, perirhinal cortex, and entorhinal cortex. “One big challenge in studying the MTL is its great anatomical variability [...]
The Surprising Origin of a Deadly Hospital Infection
C. diff might not originate from external transmission but rather from within the infected patient themselves. Hospital staff dedicate significant effort to safeguard patients from infections during their hospital stay. Through practices ranging from [...]
Google AI breakthrough – huge step in finding genes that cause diseases
Google says it has made a significant step in identifying disease-causing genes, which could help spot rare genetic disorders. A new model named AlphaMissense is able to confidently classify 89 per cent of all [...]
New Study: Everyday Pleasures Can Boost Cognitive Performance
MINDWATCH study reveals cognitive peaks with everyday pleasures. Listening to music and drinking coffee are the sorts of everyday pleasures that can impact a person’s brain activity in ways that improve cognitive performance, including [...]
Moderna reveals new highly targeted COVID-19 vaccine mRNA-1283
Moderna has developed a new and improved version of its COVID-19 vaccine. The unique formulation (mRNA-1283) reduces the vaccine's content from the full-length SARS-CoV-2 spike protein to a narrowly focused encoding of just two [...]
Leave A Comment