Many of the individuals released to long-term acute care facilities suffered from conditions that lasted for over a year.
Researchers at UC San Francisco studied COVID-19 patients in the United States who survived some of the longest and most harrowing battles with the virus. They discovered that approximately two-thirds of these survivors continued to experience a range of physical, psychiatric, and cognitive issues up to a year afterward.
The study, which was recently published in the journal Critical Care Medicine, reveals the life-altering impact of SARS-CoV-2 on these individuals, the majority of whom had to be placed on mechanical ventilators for an average of one month.
Too sick to be discharged to a skilled nursing home or rehabilitation facility, these patients were transferred instead to special hospitals known as long-term acute care hospitals (LTACHs). These hospitals specialize in weaning patients off ventilators and providing rehabilitation care, and they were a crucial part of the pandemic response.
Among the 156 study participants, 64% reported having a persistent impairment after one year, including physical (57%), respiratory (49%), psychiatric (24%), and cognitive (15%). Nearly half, or 47%, had more than one type of problem. And 19% continued to need supplemental oxygen.
The long-term follow-up helps to outline the extent of the medical problems experienced by those who became seriously ill with COVID early in the pandemic.
“We have millions of survivors of the most severe and prolonged COVID illness globally,” said the study’s first author, Anil N. Makam, MD, MAS, an associate professor of medicine at UCSF. “Our study is important to understand their recovery and long-term impairments, and to provide a nuanced understanding of their life-changing experience.”
Disabilities from long-term hospital stays
Researchers recruited 156 people who had been transferred for COVID to one of nine LTACHs in Nebraska, Texas, Georgia, Kentucky, and Connecticut between March 2020 and February 2021. They questioned them by telephone or online a year after their hospitalization. The average total length of stay in the hospital and the LTACH for the group was about two months. Their average age was 65, and most said they had been healthy before getting COVID.
In addition to their lingering ailments from COVID, the participants also had persistent problems from their long hospital stays, including painful bedsores and nerve damage that limited the use of their arms or legs.
“Many of the participants we interviewed were most bothered by these complications, so preventing these from happening in the first place is key to recovery,” Makam said.
Although 79% said they had not returned to their usual health, 99% had returned home, and 60% of those who had previously been employed said they had gone back to work.
They were overwhelmingly grateful to have survived, often describing their survival as a “miracle.” But their recovery took longer than expected.
The results underscore that it is normal to for someone who has survived such severe illness to have persistent health problems.
“The long-lasting impairments we observed are common to survivors of any prolonged critical illness, and not specific to COVID, and are best addressed through multidisciplinary rehabilitation,” Makam said.
Reference: “One-Year Recovery Among Survivors of Prolonged Severe COVID-19: A National Multicenter Cohort” by Anil N. Makam, Judith Burnfield, Ed Prettyman, Oanh Kieu Nguyen, Nancy Wu, Edie Espejo, Cinthia Blat, W. John Boscardin, E. Wesley Ely, James C. Jackson, Kenneth E Covinsky and John Votto, 10 April 2024, Critical Care Medicine.
DOI: 10.1097/CCM.0000000000006258
The work was supported by grants from the National Institutes of Health/National Institute on Aging (K23AG052603), the UCSF Research Evaluation and Allocation Committee (Carson and Hampton Research Funds), and the National Association of Long Term Hospitals. The authors had no conflicts of interest to disclose.
News
By working together, cells can extend their senses beyond their direct environment
The story of the princess and the pea evokes an image of a highly sensitive young royal woman so refined, she can sense a pea under a stack of mattresses. When it comes to [...]
Overworked Brain Cells May Hold the Key to Parkinson’s
Scientists at Gladstone Institutes uncovered a surprising reason why dopamine-producing neurons, crucial for smooth body movements, die in Parkinson’s disease. In mice, when these neurons were kept overactive for weeks, they began to falter, [...]
Old tires find new life: Rubber particles strengthen superhydrophobic coatings against corrosion
Development of highly robust superhydrophobic anti-corrosion coating using recycled tire rubber particles. Superhydrophobic materials offer a strategy for developing marine anti-corrosion materials due to their low solid-liquid contact area and low surface energy. However, [...]
This implant could soon allow you to read minds
Mind reading: Long a science fiction fantasy, today an increasingly concrete scientific goal. Researchers at Stanford University have succeeded in decoding internal language in real time thanks to a brain implant and artificial intelligence. [...]
A New Weapon Against Cancer: Cold Plasma Destroys Hidden Tumor Cells
Cold plasma penetrates deep into tumors and attacks cancer cells. Short-lived molecules were identified as key drivers. Scientists at the Leibniz Institute for Plasma Science and Technology (INP), working with colleagues from Greifswald University Hospital and [...]
This Common Sleep Aid May Also Protect Your Brain From Alzheimer’s
Lemborexant and similar sleep medications show potential for treating tau-related disorders, including Alzheimer’s disease. New research from Washington University School of Medicine in St. Louis shows that a commonly used sleep medication can restore normal sleep patterns and [...]
Sugar-Coated Nanoparticles Boost Cancer Drug Efficacy
A team of researchers at the University of Mississippi has discovered that coating cancer treatment carrying nanoparticles in a sugar-like material increases their treatment efficacy. They reported their findings in Advanced Healthcare Materials. Over a tenth of breast [...]
Nanoparticle-Based Vaccine Shows Promise in Fighting Cancer
In a study published in OncoImmunology, researchers from the German Cancer Research Center and Heidelberg University have created a therapeutic vaccine that mobilizes the immune system to target cancer cells. The researchers demonstrated that virus peptides combined [...]
Quantitative imaging method reveals how cells rapidly sort and transport lipids
Lipids are difficult to detect with light microscopy. Using a new chemical labeling strategy, a Dresden-based team led by André Nadler at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and [...]
Ancient DNA reveals cause of world’s first recorded pandemic
Scientists have confirmed that the Justinian Plague, the world’s first recorded pandemic, was caused by Yersinia pestis, the same bacterium behind the Black Death. Dating back some 1,500 years and long described in historical texts but [...]
“AI Is Not Intelligent at All” – Expert Warns of Worldwide Threat to Human Dignity
Opaque AI systems risk undermining human rights and dignity. Global cooperation is needed to ensure protection. The rise of artificial intelligence (AI) has changed how people interact, but it also poses a global risk to human [...]
Nanomotors: Where Are They Now?
First introduced in 2004, nanomotors have steadily advanced from a scientific curiosity to a practical technology with wide-ranging applications. This article explores the key developments, recent innovations, and major uses of nanomotors today. A [...]
Study Finds 95% of Tested Beers Contain Toxic “Forever Chemicals”
Researchers found PFAS in 95% of tested beers, with the highest levels linked to contaminated local water sources. Per- and polyfluoroalkyl substances (PFAS), better known as forever chemicals, are gaining notoriety for their ability [...]
Long COVID Symptoms Are Closer To A Stroke Or Parkinson’s Disease Than Fatigue
When most people get sick with COVID-19 today, they think of it as a brief illness, similar to a cold. However, for a large number of people, the illness doesn't end there. The World [...]
The world’s first AI Hospital, developed in China is transforming healthcare
Artificial Intelligence and its developments have had a revolutionary impact on society, and healthcare is not an exception. China has made massive strides in AI integrated healthcare, and continues to do so as AI [...]
Scientists Rewire Immune Cells To Supercharge Cancer-Fighting Power
Blocking a single protein boosts T cell metabolism and tumor-fighting strength. The discovery could lead to next-generation cancer immunotherapies. Scientists have identified a strategy to greatly enhance the cancer-fighting abilities of the immune system’s [...]
