In an article published today in Frontiers in Science, the team outlines how biological computers could surpass today’s electronic computers for certain applications while using a small fraction of the electricity required by today’s computers and server farms.
They’re starting by making small clusters of 50,000 brain cells grown from stem cells and known as organoids. That’s about a third the size of a fruit fly brain. They’re aiming for 10 million neurons which would be about the number of neurons in a tortoise brain. By comparison, the average human brain has more than 80 billion neurons.
The article highlights how the human brain continues to massively outperform machines for particular tasks. Humans, for example, can learn to distinguish two types of objects (such as a dog and a cat) using just a few samples, while AI algorithms need many thousands. And while AI beat the world champion in Go in 2016, it was trained on data from 160,000 games – the equivalent of playing for five hours each day, for more than 175 years.
Brains are also more energy efficient. Our brains are thought to be able to store the equivalent of more than a million times the capacity of an average home computer (2.5 petabytes), using the equivalent of just a few watts of power. US data farms, by contrast, use more than 15,000 megawatts a year, much of it generated by dozens of coal-fired power stations.
In the paper, the authors outline their plan for “organoid intelligence”, or OI, with the brain organoids grown in cell-culture. Although brain organoids aren’t “mini brains”, they share key aspects of brain function and structure. Organoids would need to be dramatically expanded from around 50,000 cells currently.
“For OI, we would need to increase this number to 10 million,” says senior author Prof Thomas Hartung of Johns Hopkins University in Baltimore.
Brett and his colleagues at Cortical Labs have already demonstrated that biocomputers based on human brain cells are possible. A recent paper in Neuron showed that a flat culture of brain cells could learn to play the video game Pong.
“We have shown we can interact with living biological neurons in such a way that compels them to modify their activity, leading to something that resembles intelligence,” says Kagan of the relatively simple Pong-playing DishBrain.
“Working with the team of amazing people assembled by Professor Hartung and colleagues for this Organoid Intelligence collaboration, Cortical Labs is now trying to replicate that work with brain organoids.”
“I would say that replicating [Cortical Labs’] experiment with organoids already fulfils the basic definition of OI,” says Thomas.
“From here on, it’s just a matter of building the community, the tools, and the technologies to realise OI’s full potential,” he said.
“This new field of biocomputing promises unprecedented advances in computing speed, processing power, data efficiency, and storage capabilities – all with lower energy needs,” Brett says. “The particularly exciting aspect of this collaboration is the open and collaborative spirit in which it was formed. Bringing these different experts together is not only vital to optimise for success but provides a critical touch point for industry collaboration.”
And the technology could also enable scientists to better study personalised brain organoids developed from skin or small blood samples of patients suffering from neural disorders, such as Alzheimer’s disease, and run tests to investigate how genetic factors, medicines, and toxins influence these conditions.
TH and LS consult AxoSim. JS is named as inventor on a patent by the University of Luxembourg on the production of midbrain organoids, which is licensed to OrganoTherapeutics SARL, Esch-sur-Alzette, Luxembourg. JS is also co-founder and shareholder of OrganoTherapeutics SARL.
AM is a co-founder and has equity interest in TISMOO, a company dedicated to genetic analysis and human brain organogenesis, focusing on therapeutic applications customized for autism spectrum disorders and other neurological disorders with genetic origins.
The terms of this arrangement have been reviewed and approved by the University of California, San Diego, in accordance with its conflict of interest policies. BK is an inventor on patents for technology related to this paper along with being employed at and holding shares in Cortical Labs Pty Ltd, Melbourne, Australia.
No specific funding or other incentives were provided for involvement in this publication.

News
Superbugs Are Losing to Science, Light, and a Little Spice
Texas A&M researchers have found that curcumin, when activated by light, can weaken antibiotic-resistant bacteria, restoring the effectiveness of conventional antibiotics. Curcumin: A Surprising Ally Against Superbugs In 2017, a woman admitted to a [...]
New Research Shatters the Perfect Pitch Myth
For decades, people believed absolute pitch was an exclusive ability granted only to those with the right genetics or early music training. But new research from the University of Surrey proves otherwise. It’s been [...]
Why Some Drinkers Suffer Devastating Liver Damage While Others Don’t
A study from Keck Medicine of USC found that heavy drinkers with diabetes, high blood pressure, or a large waistline are up to 2.4 times more likely to develop advanced liver disease. These conditions may amplify [...]
“Good” Cholesterol Could Be Bad for Your Eyes – New Study Raises Concerns
‘Good’ cholesterol may be linked to an increased risk of glaucoma in individuals over 55, while, paradoxically, ‘bad’ cholesterol may be associated with a lower risk. These findings challenge conventional beliefs about factors that [...]
Reawakening Dormant Nerve Cells: Groundbreaking Neurotechnology Restores Motor Function
A new electrical stimulation therapy for spinal muscle atrophy (SMA) has shown promise in reactivating motor neurons and improving movement. In a pilot clinical trial, three patients who received spinal cord stimulation for one [...]
AI’s Energy Crisis Solved? A Revolutionary Magnetic Chip Could Change Everything
AI is evolving at an incredible pace, but its growing energy demands pose a major challenge. Enter spintronic devices—new technology that mimics the brain’s efficiency by integrating memory and processing. Scientists in Japan have [...]
Nanotechnology for oil spill response and cleanup in coastal regions
(Nanowerk News) Cleaning up after a major oil spill is a long, expensive process, and the damage to a coastal region’s ecosystem can be significant. This is especially true for the world’s Arctic region, [...]
The Role of Nanotechnology in Space Exploration
Nanotechnology, which involves working with materials at the atomic or molecular level, is becoming increasingly important in space exploration. By improving strength, thermal stability, electrical conductivity, and radiation resistance, nanotechnology is helping create lighter, more [...]
New Study Challenges Beliefs About CBD in Pregnancy, Reveals Unexpected Risks
CBD is gaining popularity as a remedy for pregnancy symptoms like nausea and anxiety, but new research suggests it may not be as safe as many believe. A study from McMaster University found that [...]
Does COVID increase the risk of Alzheimer’s disease?
Scientists discover that even mild COVID-19 can alter brain proteins linked to Alzheimer’s disease, potentially increasing dementia risk—raising urgent public health concerns. A recent study published in the journal Nature Medicine investigated whether both mild and [...]
New MRI Study Reveals How Cannabis Alters Brain Activity and Weakens Memory
A massive new study sheds light on how cannabis affects the brain, particularly during cognitive tasks. Researchers analyzed over 1,000 young adults and found that both heavy lifetime use and recent cannabis consumption significantly reduced brain [...]
How to Assess Nanotoxicity: Key Methods and Protocols
With their high surface area and enhanced physicochemical properties, nanomaterials play a critical role in drug delivery, consumer products, and environmental technologies. However, their nanoscale dimensions enable interactions with cellular components in complex and [...]
Nanotech drug delivery shows lasting benefits, reducing need for repeat surgeries
A nanotechnology-based drug delivery system developed at UVA Health to save patients from repeated surgeries has proved to have unexpectedly long-lasting benefits in lab tests – a promising sign for its potential to help human patients. [...]
Scientists Just Found DNA’s Building Blocks in Asteroid Bennu – Could This Explain Life’s Origins?
Japanese scientists detected all five nucleobases — building blocks of DNA and RNA — in samples returned from asteroid Bennu by NASA’s OSIRIS-REx mission. NASA’s OSIRIS-REx mission brought back 121.6 grams of asteroid Bennu, unveiling nitrogen-rich organic matter, including DNA’s essential [...]
AI-Designed Proteins – Unlike Any Found in Nature – Revolutionize Snakebite Treatment
Scientists have pioneered a groundbreaking method to combat snake venom using newly designed proteins, offering hope for more effective, accessible, and affordable antivenom solutions. By utilizing advanced computational techniques and deep learning, this innovative [...]
New nanosystem offers hope for improved diagnosis and treatment of tongue cancer
A pioneering study has unveiled the Au-HN-1 nanosystem, a cutting-edge approach that promises to transform the diagnosis and treatment of tongue squamous cell carcinoma (TSCC). By harnessing gold nanoparticles coupled with the HN-1 peptide, [...]