A single dose of the Pfizer coronavirus vaccine is “highly protective” after three weeks, according to a study.
Researchers at the University of East Anglia (UEA) said the coronavirus vaccine developed by Pfizer and BioNTech was still effective after 21 days without a ‘top up’ dose in the recommended time frame.
It comes after a study found that the Oxford coronavirus vaccine offers protection of 76 per cent up to 12 weeks after a single dose and may reduce transmission by 67 per cent.
The UEA study of the Pfizer jab, which has not yet been peer-reviewed, looked at data from Israel where the vaccine has been rolled out. Scientists found the vaccine becomes 90 per cent effective after 21 days – supporting UK plans to delay the timing of a second jab.
While it is not yet known how long immunity lasted beyond 21 days without a second dose, researchers believe it is “unlikely” to majorly decline during the following nine weeks.
But scientists warned people’s risk of infection doubled in the first eight days after the Pfizer vaccine jab, citing people becoming less cautious as a possible cause.
“A recent non peer-reviewed pre-print paper based on Israel’s experience looked at data from 500,000 people who had been given the Pfizer vaccine. It reported that a single dose may not provide adequate protection,” said lead researcher Professor Paul Hunter, from UEA’s Norwich Medical School.
“But we saw a number of flaws in how they looked at the data including the fact that they did not attempt to estimate the effectiveness of the vaccine from day 18 onwards. This would have given a better indication of how effective a single dose of the vaccine could be if the second dose was delayed by up to 12 weeks.”
Researchers analysed data to see the impact of the Israeli vaccination programme on case numbers, and went on to estimate vaccine effectiveness over time. They found that after the initial vaccination case numbers increased for eight days before declining “to low levels” by day 21.
“Surprisingly, the daily incidence of cases increased strongly after vaccination till about day eight – approximately doubling,” Prof Hunter said.
Image Credit: Envato/Amanda Scott
Post by Amanda Scott, NA CEO. Follow her on twitter @tantriclens
Thanks to Heinz V. Hoenen. Follow him on twitter: @HeinzVHoenen
News
Efficiently smuggling drugs into cells
Modern vaccines such as those against Sars-CoV-2 use tiny lipid spheres to transport genetic information into cells and let the body build up an immune defense against the virus. A team of scientists from [...]
B.C.’s biotech sector plays key role in developing COVID-19 treatments and vaccines
By early 2020, concern was mounting about a new, deadly coronavirus first detected in Wuhan, China. The World Health Organization had declared the coronavirus outbreak a global health emergency just days before. There had been [...]
Graphene-coated Face Masks: COVID-19 Miracle or Another Health Risk?
As a COVID-19 and medical device researcher, I understand the importance of face masks to prevent the spread of the coronavirus. So I am intrigued that some mask manufacturers have begun adding graphene coatings [...]
Scientists Uncover Nanoplastics and Other Pollutants Released from Disposable Face Masks
Swansea University scientists have uncovered potentially dangerous chemical pollutants that are released from disposable face masks when submerged in water. The research reveals high levels of pollutants, including lead, antimony, and copper, within the [...]
Nanotechnology offers new hope for bowel cancer patients
Bowel cancer survival rates could be improved if chemotherapy drugs were delivered via tiny nanoparticles to the diseased organs rather than oral treatment. That's the finding from Indian and Australian scientists who have undertaken [...]
Pfizer’s COVID-19 treatment pill could be available by year’s end
Pfizer CEO Albert Bourla says his company’s experimental COVID-19 treatment, a pill that can be taken at the first sign of the illness, could be available before the end of the year. Speaking on CNBC, Bourla said clinical [...]
New “Nanotraps” Could Capture and Destroy Coronavirus Within the Body
At the University of Chicago, scientists have developed an absolutely innovative, promising treatment for COVID-19 in the form of nanoparticles with the ability to trap SARS-CoV-2 viruses inside the body and use the body’s [...]
Nanobodies inhibit SARS-CoV-2 infection, including emergent variants
Australian researchers have identified neutralizing nanobodies that block the SARS-CoV-2 virus from entering cells in preclinical models. The discovery paves the way for further investigations into nanobody-based treatments for COVID-19. Published in PNAS, the research [...]
DNA robots designed in minutes instead of days
Someday, scientists believe, tiny DNA-based robots and other nanodevices will deliver medicine inside our bodies, detect the presence of deadly pathogens, and help manufacture increasingly smaller electronics. Researchers took a big step toward that [...]
Scientists’ horror over ‘escape mutation’ of new COVID strain
Experts have discovered what they believe is the world’s most mutated COVID strain – and there’s one detail in particular that has scientists worried. Scientists have detected what is believed to be the world’s [...]
Coronavirus Does Not Infect the Brain but Still Inflicts Damage
SARS-CoV-2, the virus that causes COVID-19, likely does not directly infect the brain but can still inflict significant neurological damage, according to a new study from neuropathologists, neurologists, and neuroradiologists at Columbia University Vagelos [...]
Research finds a potential new ‘silver bullet’ nanoparticle to treat brain cancer
ANSTO has contributed to a comprehensive investigation of a promising type of nanoparticle that could potentially be used for intractable brain cancers in a combined therapy. The study, which was led by Dr. Moeava [...]
Trial to study effect of immune system on Covid reinfection
The immune response needed to protect people against reinfection with the coronavirus will be explored in a new human challenge trial, researchers have revealed. Human challenge trials involve deliberately exposing healthy people to a [...]
Duke working on developing flu shot using new CoV vaccine technology
Researchers from Duke University are developing a flu shot with the new technology that was used for two coronavirus vaccines. Both the Pfizer-BioNTech and the Moderna shots use part of the virus's genetic code [...]
Long-acting injectable medicine as potential route to COVID-19 therapy
Researchers from the University of Liverpool have shown the potential of repurposing an existing and cheap drug into a long-acting injectable therapy that could be used to treat Covid-19. In a paper published in the journal Nanoscale, [...]
Superbug killer: New nanotech destroys bacteria and fungal cells
Researchers have developed a new superbug-destroying coating that could be used on wound dressings and implants to prevent and treat potentially deadly bacterial and fungal infections. The material is one of the thinnest antimicrobial [...]
