Researchers of the Institute of Biotechnology and Biomedicine (IBB-UAB) have generated four peptides, molecules smaller than proteins, capable of self-assembling in a controlled manner to form nanomaterials. The research, published in the journal ACS Nano, was conducted by Salvador Ventura, Marta Díaz Caballero and Susanna Navarro (IBB-UAB), and included the collaboration of Isabel Fuentes and Francesc Teixidor (Institute of Materials Science of Barcelona, ICMAB-CSIC).
In biotechnology, generating functional synthetic amyloid structures to form nanostructures by imitating the natural generation process is not new. The assembly of proteins into stable fibres allows creating supramolecular shapes that no isolated protein can create, and which are used as nanoconductors, photovoltaic structures, biosensors and catalysts.
Quite recently, researchers began synthesizing prion protein sequences to form nanomaterials. The interest in these sequences lies in the fact that the proteins assemble in a slower and more controlled manner, forming highly ordered, nontoxic nanostructures. However, the fact that the sequence is so long, with over 150 amino acids, makes it very difficult and expensive to synthesise.
“We have demonstrated that an adequate design can permit the size of synthetic prion sequences to be reduced down to only 7 amino acids, while conserving the same properties. The four peptides we have fabricated are the shortest structures of this type created until now, and are capable of forming stable fibril assemblies,” says Salvador Ventura, researcher at the IBB and the UAB Department of Biochemistry and Molecular Biology.
Image Credit: Credit: IBB-UAB
News This Week
If nanotechnology has one clear image in the collective pop-culture consciousness, it is that of nanorobots, nanoscale machines capable of performing mechanical functions. When considering the potential of such a technology, the more astute may [...]
Artificial intelligence (AI) is clearly a growing force in the technology industry. Chatbots and virtual assistants are becoming a key part of new products, and robots are taking center stage at conferences and showing [...]
In what seems like the blink of an eye, mentions of artificial intelligence have become ubiquitous in the healthcare industry. From deep learning algorithms that can read CT scans faster than humans to natural [...]
The International Conference On Nanomedicine And Nanobiotechnology is an annual event. It hosts high-profile plenary speakers, world-class researchers, oral and poster presentations, workshops, sponsor exhibits and afterworks. It is a great opportunity to share [...]
SYDNEY, (UrduPoint / Pakistan Point News, app - 14th Sep, 2018 ) :Scientists in Australia have developed a ground-breaking new way to strip impurities from waste water, with the research set to have massive [...]
Two teams of scientists from the Technion-Israel Institute of Technology have collaborated to conduct groundbreaking research leading to the development of a new and innovative scientific field: Quantum Metamaterials. The findings are presented [...]
A team of eight EPFL students has come up with a portable biosensor that can measure the amount of vancomycin in a patient's blood stream, enabling doctors to better control the dosage and reduce [...]
Researchers have developed a see-through, dual-layered, mesh EEG device which is capable of measuring the electrical activity of individual neurons… Researchers from Boston Children’s Hospital and Northeastern University developed a ‘see-through’ EEG device to [...]