Millions of people in England may be living with Long Covid without even realizing it.
A large-scale analysis found that nearly 10% suspect they might have the condition but remain uncertain, often due to lack of diagnosis, stigma, or self-doubt.
Many Are Unsure If They Have Long Covid
Nearly one in ten people (9.1%) in England suspect they may have Long Covid but are unsure, according to a new analysis of NHS England survey data conducted by the University of Southampton.
Researchers also found that 4.8% of respondents reported having Long Covid, with higher rates among individuals from disadvantaged backgrounds, certain ethnic groups, parents or caregivers, and those with existing long-term health conditions.
The study, published today (March 18) in the journal Health Expectations, highlights ongoing disparities in how Long Covid affects different populations.
The Unfair Burden of Long Covid
Professor Nisreen A. Alwan, a leading Long Covid researcher and co-author of the study, emphasized the disproportionate impact of the condition.
"This analysis adds further evidence of the unfairness of Long Covid, with people who are already disadvantaged in society more likely to be affected.
"It also shows us that many people aren't sure if they have it, and may need diagnosis, treatment, and support.
"Long Covid is still a very significant issue impacting individuals, families, the economy and wider society. We need to do more to prevent it, diagnose it, and properly support people who are affected by it."
A Widespread Yet Uncertain Condition
Long Covid is a chronic condition induced by COVID-19 infection that can have a significant impact on people's daily lives. Symptoms include fatigue, feeling short of breath, 'brain fog', and heart palpitations, amongst many others.
University of Southampton researchers analysed over 750,000 responses to the GP Patient Survey (England) 2023 to explore the prevalence of Long Covid, and the factors associated with both having the condition and being uncertain of having it.
Why Some People Stay Undiagnosed
They found that people aged under 25 years, males, people from particular ethnic minorities, and people without long-term conditions were more likely to be unsure if they had Long Covid.
Men are generally less likely to seek medical advice than women, which could partly explain their higher level of uncertainty. The team also says stigma and self-doubt could discourage people from seeking a diagnosis.
Raising Awareness and Bridging Gaps
Mirembe Woodrow, who is studying for a PhD at Southampton and who carried out the analysis, said: "We were really surprised to find so many people weren't sure whether they had Long Covid or not, and the study shows there is still work to do to increase awareness of the condition and remove barriers to accessing diagnosis, treatment, and support.
"We don't want Long Covid to be another factor that contributes to the widening health gap in the UK."
Long Covid Uncertainty Persists
The most recent data from the 2024 GP Patient Survey indicates Long Covid prevalence and uncertainty are not declining (5.0% and 9.0%). Professor Alwan's team intends to carry out further work using the survey to understand what could be driving inequality in prevalence, impact, and support for Long Covid.
Reference: "Exploring Long Covid prevalence and patient uncertainty by sociodemographic characteristics using GP Patient Survey data" 17 March 2025, Health Expectations.
DOI: 10.1111/hex.70202
News
COVID-19 still claims more than 100,000 US lives each year
Centers for Disease Control and Prevention researchers report national estimates of 43.6 million COVID-19-associated illnesses and 101,300 deaths in the US during October 2022 to September 2023, plus 33.0 million illnesses and 100,800 deaths [...]
Nanomedicine in 2026: Experts Predict the Year Ahead
Progress in nanomedicine is almost as fast as the science is small. Over the last year, we've seen an abundance of headlines covering medical R&D at the nanoscale: polymer-coated nanoparticles targeting ovarian cancer, Albumin recruiting nanoparticles for [...]
Lipid nanoparticles could unlock access for millions of autoimmune patients
Capstan Therapeutics scientists demonstrate that lipid nanoparticles can engineer CAR T cells within the body without laboratory cell manufacturing and ex vivo expansion. The method using targeted lipid nanoparticles (tLNPs) is designed to deliver [...]
The Brain’s Strange Way of Computing Could Explain Consciousness
Consciousness may emerge not from code, but from the way living brains physically compute. Discussions about consciousness often stall between two deeply rooted viewpoints. One is computational functionalism, which holds that cognition can be [...]
First breathing ‘lung-on-chip’ developed using genetically identical cells
Researchers at the Francis Crick Institute and AlveoliX have developed the first human lung-on-chip model using stem cells taken from only one person. These chips simulate breathing motions and lung disease in an individual, [...]
Cell Membranes May Act Like Tiny Power Generators
Living cells may generate electricity through the natural motion of their membranes. These fast electrical signals could play a role in how cells communicate and sense their surroundings. Scientists have proposed a new theoretical [...]
This Viral RNA Structure Could Lead to a Universal Antiviral Drug
Researchers identify a shared RNA-protein interaction that could lead to broad-spectrum antiviral treatments for enteroviruses. A new study from the University of Maryland, Baltimore County (UMBC), published in Nature Communications, explains how enteroviruses begin reproducing [...]
New study suggests a way to rejuvenate the immune system
Stimulating the liver to produce some of the signals of the thymus can reverse age-related declines in T-cell populations and enhance response to vaccination. As people age, their immune system function declines. T cell [...]
Nerve Damage Can Disrupt Immunity Across the Entire Body
A single nerve injury can quietly reshape the immune system across the entire body. Preclinical research from McGill University suggests that nerve injuries may lead to long-lasting changes in the immune system, and these [...]
Fake Science Is Growing Faster Than Legitimate Research, New Study Warns
New research reveals organized networks linking paper mills, intermediaries, and compromised academic journals Organized scientific fraud is becoming increasingly common, ranging from fabricated research to the buying and selling of authorship and citations, according [...]
Scientists Unlock a New Way to Hear the Brain’s Hidden Language
Scientists can finally hear the brain’s quietest messages—unlocking the hidden code behind how neurons think, decide, and remember. Scientists have created a new protein that can capture the incoming chemical signals received by brain [...]
Does being infected or vaccinated first influence COVID-19 immunity?
A new study analyzing the immune response to COVID-19 in a Catalan cohort of health workers sheds light on an important question: does it matter whether a person was first infected or first vaccinated? [...]
We May Never Know if AI Is Conscious, Says Cambridge Philosopher
As claims about conscious AI grow louder, a Cambridge philosopher argues that we lack the evidence to know whether machines can truly be conscious, let alone morally significant. A philosopher at the University of [...]
AI Helped Scientists Stop a Virus With One Tiny Change
Using AI, researchers identified one tiny molecular interaction that viruses need to infect cells. Disrupting it stopped the virus before infection could begin. Washington State University scientists have uncovered a method to interfere with a key [...]
Deadly Hospital Fungus May Finally Have a Weakness
A deadly, drug-resistant hospital fungus may finally have a weakness—and scientists think they’ve found it. Researchers have identified a genetic process that could open the door to new treatments for a dangerous fungal infection [...]
Fever-Proof Bird Flu Variant Could Fuel the Next Pandemic
Bird flu viruses present a significant risk to humans because they can continue replicating at temperatures higher than a typical fever. Fever is one of the body’s main tools for slowing or stopping viral [...]















