The coronavirus disease 2019 (COVID-19) pandemic has caused several waves of infections in many world regions, so strong as to overwhelm local healthcare services. In this new situation, faced with an unknown virus, the need is to produce clinical guidelines that help recognize and manage critical COVID-19. Meanwhile, conditions such as chronic obstructive pulmonary disease (COPD) are linked to a markedly increased risk of death in community pneumonia.
A new preprint available on the bioRxiv* preprint server uses computational algorithms to tease out the interrelationships between these two conditions that cause similar outcomes. Based on protein-protein interactions (PPIs), the paper shows the presence of ten genes that overlap between the two illnesses, also shared by several other deadly and debilitating diseases.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread worldwide and has led to approximately five million deaths so far. Older adults are by far the worst affected by COVID-19, with this illness accounting for 80% of all deaths in the 65-and-above age group.
Interestingly, this age group is also at the highest risk of COPD. In this condition, found in a tenth of people over 40 years, the airflow is limited, mostly caused by chronic bronchitis or emphysema. Many genetic and environmental factors play a part in the occurrence of this disease, including irritant chemical inhalation or smoking, though only about a fifth of smokers have COPD.
While COPD patients rarely acquire COVID-19, the risk of death is much higher than non-COPD patients. Accordingly, recent recommendations have been made to update the diagnostic and treatment protocols for COPD.
Independent of COVID-19, COPD is responsible for the third-largest number of deaths in the world. Considered a polygenic condition, it renders its victims susceptible to severe disease and death following the triggering of a cytokine storm by SARS-CoV-2 infection.
The latter causes symptoms only after about five days, with death, if it occurs, taking place at an average of 14 days later, depending on the patient’s age and immunity.
However, COPD is a treatable condition, if not curable, with current therapies able to maintain a high quality of life and keep the patient safe from other respiratory illnesses. When it coexists with COVID-19, the respiratory tract suffers because of the pre-existing lung injury. Thus, severe COVID-19 is fourfold more likely in such patients.
COPD patients have higher levels of the viral entry receptor, the angiotensin-converting enzyme 2 (ACE2), as do smokers.
What did the study show?
The researchers constructed a PPI network using available data on ~5,500 COVID-19 and 296 COPD gene expression profiles to elucidate the genes involved in such complicated conditions.
They first identified 248 overlapping genes, of which ten were found to be the top common genes. These are implicated in cell-cell communication and metabolism, development, the response to stimuli, and biological regulation. These genes are mostly also involved in pathways implicated in malaria, trypanosomiasis, and inflammatory bowel disease (IBD).
The Interleukin 10 (IL 10) gene is the first common gene, or the hub gene, expressing a regulatory cytokine that modulates the inflammatory response. It is markedly upregulated in associated with the cytokine storm in severe COVID-19 patients admitted to the intensive care unit (ICU).
It is, however, low in patients with COPD who have dramatic airway inflammation. IL-10 thus serves as a marker of disease severity and is useful for monitoring treatment.
The study similarly elucidates the role of Toll-like receptor 4 (TLR4), expressed by multiple immune cells and found to be required for the initiation of inflammatory responses. When it increases excessively, hyperinflammation may set in.
The TLRs are driven by the recognition of viral RNA or dsDNA intermediate forms (called pathogen-associated molecular patterns (PAMPs). These are formed from the viral genome and recognized by pattern recognition receptors, especially the TLRs, triggering further inflammatory antiviral cascades that eventually clear the virus.
TLR4 is found to have the highest PPI with the viral spike protein compared to other TLRs. SARS-CoV-2 is found to enhance the expression of interferon-stimulated genes (ISGs) in the respiratory tract. However, the higher levels of ISG expression can cause greater ACE2 expression as well. Research shows how lung surfactants block the infection by TLR4 binding and activation.
Other hub genes include the Tumor necrosis factor (TNF), a key inflammatory mediator that is elevated in acute inflammation due to viral infection, and chronic or systemic inflammation. High TNF levels are found in patients with COPD and patients with acute COVID-19 and COPD.
Fourthly, IL6 is a potent inflammatory cytokine, with multiple actions in the inflammatory cascade. It is produced by many cell types, including epithelial airway cells and alveolar macrophages. High IL6 levels are associated with worse lung function and an accelerated rate of deterioration and skeletal muscle weakness in COPD.
IL8, also known as CXCL8, is a mediator for neutrophil tracking and is implicated in inflammatory processes, notably after viral infections. Respiratory muscle weakness in patients with COPD is traceable in part to IL8 activity, with rises in the level of this cytokine during COPD exacerbations. High CXCL8 levels are suggested to be the cause of death in severe COVID-19.
IL4 is an activator of the JAK-STAT pathway that drives inflammation and mediates hyper-responsiveness of the airways, a key COPD element.
The seventh hub gene is ICAM1, an intercellular adhesion molecule that is overproduced during early inflammation, causing the premature release of neutrophils. This molecule is elevated in COPD patients. With moderate to severe COVID-19, ICAM1 levels are high and increasing but drop in convalescence.
This may mean that these molecules are markers of COVID-19 severity. Besides, they also trigger coagulation defects. The four intracellular binding sites for SARS-CoV-2 within human cells are highly expressed in COPD patients.
The eighth hub gene is interferon-gamma (IFN-γ). This is known to be a key risk gene for COVID-19 patients with lung disease. COPD patients have a more than five times higher risk of severe COVID-19
TLR2 is the ninth hub gene, associated with a decline in lung function and evidence of inflammation in sputum, indicating its role in COPD pathogenesis and exacerbation. It is also known to recognize SARS-CoV-2 particles and may be part of the infection-pulmonary embolism pathway.
The last of the hub genes is IL18, which is thought to be tied to the abnormal inflammatory pathways in COPD. Anti-IL 18 antibodies neutralize the damage and inflammation caused by COPD in preclinical models.
News
Scientists Unlock a New Way to Hear the Brain’s Hidden Language
Scientists can finally hear the brain’s quietest messages—unlocking the hidden code behind how neurons think, decide, and remember. Scientists have created a new protein that can capture the incoming chemical signals received by brain [...]
Does being infected or vaccinated first influence COVID-19 immunity?
A new study analyzing the immune response to COVID-19 in a Catalan cohort of health workers sheds light on an important question: does it matter whether a person was first infected or first vaccinated? [...]
We May Never Know if AI Is Conscious, Says Cambridge Philosopher
As claims about conscious AI grow louder, a Cambridge philosopher argues that we lack the evidence to know whether machines can truly be conscious, let alone morally significant. A philosopher at the University of [...]
AI Helped Scientists Stop a Virus With One Tiny Change
Using AI, researchers identified one tiny molecular interaction that viruses need to infect cells. Disrupting it stopped the virus before infection could begin. Washington State University scientists have uncovered a method to interfere with a key [...]
Deadly Hospital Fungus May Finally Have a Weakness
A deadly, drug-resistant hospital fungus may finally have a weakness—and scientists think they’ve found it. Researchers have identified a genetic process that could open the door to new treatments for a dangerous fungal infection [...]
Fever-Proof Bird Flu Variant Could Fuel the Next Pandemic
Bird flu viruses present a significant risk to humans because they can continue replicating at temperatures higher than a typical fever. Fever is one of the body’s main tools for slowing or stopping viral [...]
What could the future of nanoscience look like?
Society has a lot to thank for nanoscience. From improved health monitoring to reducing the size of electronics, scientists’ ability to delve deeper and better understand chemistry at the nanoscale has opened up numerous [...]
Scientists Melt Cancer’s Hidden “Power Hubs” and Stop Tumor Growth
Researchers discovered that in a rare kidney cancer, RNA builds droplet-like hubs that act as growth control centers inside tumor cells. By engineering a molecular switch to dissolve these hubs, they were able to halt cancer [...]
Platelet-inspired nanoparticles could improve treatment of inflammatory diseases
Scientists have developed platelet-inspired nanoparticles that deliver anti-inflammatory drugs directly to brain-computer interface implants, doubling their effectiveness. Scientists have found a way to improve the performance of brain-computer interface (BCI) electrodes by delivering anti-inflammatory drugs directly [...]
After 150 years, a new chapter in cancer therapy is finally beginning
For decades, researchers have been looking for ways to destroy cancer cells in a targeted manner without further weakening the body. But for many patients whose immune system is severely impaired by chemotherapy or radiation, [...]
Older chemical libraries show promise for fighting resistant strains of COVID-19 virus
SARS‑CoV‑2, the virus that causes COVID-19, continues to mutate, with some newer strains becoming less responsive to current antiviral treatments like Paxlovid. Now, University of California San Diego scientists and an international team of [...]
Lower doses of immunotherapy for skin cancer give better results, study suggests
According to a new study, lower doses of approved immunotherapy for malignant melanoma can give better results against tumors, while reducing side effects. This is reported by researchers at Karolinska Institutet in the Journal of the National [...]
Researchers highlight five pathways through which microplastics can harm the brain
Microplastics could be fueling neurodegenerative diseases like Alzheimer's and Parkinson's, with a new study highlighting five ways microplastics can trigger inflammation and damage in the brain. More than 57 million people live with dementia, [...]
Tiny Metal Nanodots Obliterate Cancer Cells While Largely Sparing Healthy Tissue
Scientists have developed tiny metal-oxide particles that push cancer cells past their stress limits while sparing healthy tissue. An international team led by RMIT University has developed tiny particles called nanodots, crafted from a metallic compound, [...]
Gold Nanoclusters Could Supercharge Quantum Computers
Researchers found that gold “super atoms” can behave like the atoms in top-tier quantum systems—only far easier to scale. These tiny clusters can be customized at the molecular level, offering a powerful, tunable foundation [...]
A single shot of HPV vaccine may be enough to fight cervical cancer, study finds
WASHINGTON -- A single HPV vaccination appears just as effective as two doses at preventing the viral infection that causes cervical cancer, researchers reported Wednesday. HPV, or human papillomavirus, is very common and spread [...]
