-
- Scientists have created a bacterium that is resistant to all viruses.
- Using strands of RNA, researchers re-coded the organism so that when viruses try to invade, their replication instructions get all mixed around.
- The team hopes their new tech will eventually be used to create virus-resistant bacteria to be used in producing things like insulin.
Viruses are often incredibly hard to treat. We're certainly not strangers to that fact after the last few years. They're extremely adaptable and very hard to destroy, making them very dangerous to human health. Antivirals can sometimes help a little, but usually—you get a virus, you're stuck with it.
But what if instead of trying to treat these sneaky little beasts, we could stop them in their tracks before they even enter our cells? Create an organism that's basically immune to viruses right off the bat? Well, geneticists at Harvard claim they've done just that.
In a recent study, a team of researchers announced that they had made an E. coli bacterium immune to all viruses. Well, all they could test in the lab, anyway.
"We can't say it's fully virus-resistant," Akos Nyerges, genetics researcher and one of the authors of the study, said in a press release, "but so far, based on extensive laboratory experiments and computational analysis, we haven't found a virus that can break it."The researchers decided to take a "delete and trick" approach in the creation of their super-organism. They first went in and stripped the bacterium of three of its codons, which are little chunks of genetic code. And they didn't just pick at random—they carefully deleted the codons that viruses latch onto to begin replicating themselves.
So, problem solved, right? Wrong.
It turns out that viruses can bring their own versions of these codons into the cell and bypass the deletions altogether, kind of like bringing a power adapter on an international trip so you can plug your devices into wrong-shaped outlets.
So, in step two, the scientists got a little tricky with RNA. Specifically with tRNA, or transfer RNA. When a virus is trying, to begin the replication process, it basically plugs a strand of tRNA into a codon, and the codon "prints" out an amino acid. That process creates proteins.
But critically, if the codons "print" the wrong amino acid, nothing gets made. You just get a string of gibberish instructions that halt the viral duplication process in its tracks. So, the researcher team inserted strands of tRNA into the E. coli that would tell the codons brought in by the viruses to produce the wrong amino acids. Theoretically, the virus could bring in it's own tRNA too, but the researchers seem convinced that their tRNA strands win that fight.
With the codons now printing out completely wrong amino acids and the virus's replication instructions being turned into nonsense, the infection was stopped before it even got started. With that success under their belt, the team eventually wants to use their new gene tech to create strands of virus-resistant bacteria that can be used to produce things like insulin.
And who knows? Maybe someday, we'll be able to extend that tech to ourselves.
News
Two Hidden Forces Help Build the Human Brain Before Birth
Scientists have uncovered two surprising forces that help guide how the human brain forms before birth. Before birth, the human brain is shaped in large part by an unusual class of stem cells known [...]
Researchers Uncover a Hidden Trigger Behind Chronic Inflammation
The findings offer new insights that could help guide the development of future therapies. A protein called human resistin may help flip on one of the immune system’s most powerful inflammatory switches. Researchers at [...]
Scientists Have Uncovered Previously Hidden Microbial Activity on Human Skin
The most abundant microbes on your skin may not be the ones doing most of the work. Human skin supports vast communities of bacteria, fungi, and viruses that can influence its protective barrier, immune [...]
Brazilian Tree Compounds Fight COVID-19 on Multiple Fronts
Scientists found compounds in a Brazilian tree that hit SARS-CoV-2 on multiple fronts, revealing a promising new lead in the search for COVID-19 treatments. Researchers have found that galloylquinic acids extracted from the leaves [...]
Cutting Two Amino Acids Slowed Prostate Cancer in Mice
A newly identified link between amino acid metabolism and cholesterol production may help prostate tumors adapt to hormone therapy. Prostate cancer can find ways around treatments designed to deprive tumors of the hormones they [...]
Largest-Ever Physics Survey Raises New Doubts About Our Model of the Universe
Physicists around the world remain deeply divided on key mysteries of the universe, from dark matter to quantum gravity. The standard cosmological model failed to gain majority support, and no leading theory dominated the [...]
Scientists Just Overturned a 100-Year-Old Belief About Bacteria in the Lungs
New findings raise questions about the role of microbes living in the lungs. More than 35 trillion bacteria live throughout the human body, forming microbiomes in the gut, mouth, lungs, skin, and urogenital tract. [...]
GHCE Concept
From the preface of the book Global Health Care Equivalency in the Age of Nanotechnology, Nanomedicine and Artificial Intelligence, Edited by Frank Boehm: Since the publication of my first book (Nanomedical Device and Systems [...]
Novartis, Ionis drug failure spurs questions
Pelacarsen didn’t protect heart health despite lowering levels of a protein particle, “Lp(a),” in a large clinical trial — a result with important implications for cardiovascular drug research. Dive Brief: An RNA drug from [...]
New injectable treatment helps the brain rebuild after stroke
Biomedical engineers at Duke University have created an injectable biomaterial that may help the brain recover from damage left behind by an ischemic stroke. In experiments with mice, the material transformed the cavity created [...]
Scientists Discover a Hidden “Immune Organ” Inside the Skull
Researchers discovered lymph node-like immune hubs inside skull bone marrow that appear to act as rapid-response centers for the brain. For decades, the brain was thought to operate largely apart from the immune system. [...]
Engineered tRNAs and lipid nanoparticles target nonsense mutation cystic fibrosis
Researchers have developed a potential new approach for treating a form of cystic fibrosis caused by so-called nonsense mutations, combining chemically modified transfer RNAs with lipid nanoparticles designed to deliver the therapy directly to [...]
New pancreatic cancer drug carries a $39,800 monthly list price
A groundbreaking treatment for one of the most common forms of pancreatic cancer has been approved in pill form by the FDA. Revolution Medicines’ oral tablet daraxonrasib, branded as Rasonque, reduced the risk of [...]
Researchers Have Discovered a New Way To Reduce Chronic Nerve Pain
A cancer-linked protein called BRAF may help drive chronic nerve pain, and existing cancer drugs targeting it reduced pain sensitivity in preclinical models. Chronic nerve pain can persist long after an injury and often [...]
Our books now available worldwide!
Online Sellers other than Amazon, Routledge, and IOPP Indigo Global Health Care Equivalency in the Age of Nanotechnology, Nanomedicine and Artifcial Intelligence Global Health Care Equivalency In The Age Of Nanotechnology, Nanomedicine And Artificial [...]
Quantum-Enabled Regenerative Health: Reimagining Wellness, Precision Health and Longevity Medicine
Introduction Healthcare is approaching a frontier where the quantum portfolio could influence not only how disease is diagnosed and treated, but how health itself is measured, modeled, predicted and preserved. Quantum computing, quantum simulation, [...]















