A new COVID-19 vaccine developed in South Australia and administered with a needle-free device is to begin human trials.
Designed by University of Adelaide researchers the DNA vaccine also targets the Omicron variant of the virus and can be adapted for future variants.
DNA vaccines require simple engineering design modifications that can be made quickly to adapt to new strains.
It is being manufactured in SA at the BioCina facility in Adelaide.
Lead investigator Branka Grubor-Bauk, head of viral immunology at the University of Adelaide's Medical School, is calling for volunteers over 18 who were triple vaccinated more than three months ago and have not had COVID-19, to join the trial.
"We need to continue developing next-generation COVID-19 vaccines because the virus will continue to mutate, particularly in countries with low vaccination rates and high rates of uncontrolled transmission," Associate Professor Grubor-Bauk said.
"As we live with COVID-19, we still have vulnerable populations at risk of severe disease.
"It is vitally important to evaluate variant-specific booster vaccines."
The vaccine will be administered using a needle-free device from American company Pharmajet which delivers a micro-jet spray of liquid, which goes under the skin and is painless.
It can also be shipped at room temperature, stored for five years and manufactured in existing facilities.
SA Pathology Clinical Immunologist Pravin Hissaria said the development of highly effective vaccines remained the most effective strategy in containing COVID-19.
"It is important that we continue to innovate and adapt to the evolving viral strains and deliver precise and effective vaccines," Associate Professor Hissaria said.
The Hospital Research Foundation Group has been funding the vaccine research, with chief executive Paul Flynn hailing its speedy development.
"This trial will ultimately determine if the vaccine is safe, but I encourage South Australians interested in participating to put their trust in a respected, safe, peer-reviewed team."
The human trials are due to begin this week.
News
Plastic Without End: Are We Polluting the Planet for Eternity?
The Kunming Montreal Global Biodiversity Framework calls for the elimination of plastic pollution by 2030. If that goal has been clearly set, why have meaningful measures that create real change still not been implemented? [...]
Scientists Rewire Natural Killer Cells To Attack Cancer Faster and Harder
Researchers tested new CAR designs in NK-92 cells and found the modified cells killed tumor cells more effectively, showing stronger anti-cancer activity. Researchers at the Ribeirão Preto Blood Center and the Center for Cell-Based [...]
New “Cellular” Target Could Transform How We Treat Alzheimer’s Disease
A new study from researchers highlights an unexpected player in Alzheimer’s disease: aging astrocytes. Senescent astrocytes have been identified as a major contributor to Alzheimer’s progression. The cells lose protective functions and fuel inflammation, particularly in [...]
Treating a Common Dental Infection… Effects That Extend Far Beyond the Mouth
Successful root canal treatment may help lower inflammation associated with heart disease and improve blood sugar and cholesterol levels. Treating an infected tooth with a successful root canal procedure may do more than relieve [...]
Microplastics found in prostate tumors in small study
In a new study, researchers found microplastics deep inside prostate cancer tumors, raising more questions about the role the ubiquitous pollutants play in public health. The findings — which come from a small study of 10 [...]
All blue-eyed people have this one thing in common
All Blue-Eyed People Have This One Thing In Common Blue Eyes Aren’t Random—Research Traces Them Back to One Prehistoric Human It sounds like a myth at first — something you’d hear in a folklore [...]
Scientists reveal how exercise protects the brain from Alzheimer’s
Researchers at UC San Francisco have identified a biological process that may explain why exercise sharpens thinking and memory. Their findings suggest that physical activity strengthens the brain's built in defense system, helping protect [...]
NanoMedical Brain/Cloud Interface – Explorations and Implications. A new book from Frank Boehm
New book from Frank Boehm, NanoappsMedical Inc Founder: This book explores the future hypothetical possibility that the cerebral cortex of the human brain might be seamlessly, safely, and securely connected with the Cloud via [...]
Deadly Pancreatic Cancer Found To “Wire Itself” Into the Body’s Nerves
A newly discovered link between pancreatic cancer and neural signaling reveals a promising drug target that slows tumor growth by blocking glutamate uptake. Pancreatic cancer is among the most deadly cancers, and scientists are [...]
This Simple Brain Exercise May Protect Against Dementia for 20 Years
A long-running study following thousands of older adults suggests that a relatively brief period of targeted brain training may have effects that last decades. Starting in the late 1990s, close to 3,000 older adults [...]
Scientists Crack a 50-Year Tissue Mystery With Major Cancer Implications
Researchers have resolved a 50-year-old scientific mystery by identifying the molecular mechanism that allows tissues to regenerate after severe damage. The discovery could help guide future treatments aimed at reducing the risk of cancer [...]
This New Blood Test Can Detect Cancer Before Tumors Appear
A new CRISPR-powered light sensor can detect the faintest whispers of cancer in a single drop of blood. Scientists have created an advanced light-based sensor capable of identifying extremely small amounts of cancer biomarkers [...]
Blindness Breakthrough? This Snail Regrows Eyes in 30 Days
A snail that regrows its eyes may hold the genetic clues to restoring human sight. Human eyes are intricate organs that cannot regrow once damaged. Surprisingly, they share key structural features with the eyes [...]
This Is Why the Same Virus Hits People So Differently
Scientists have mapped how genetics and life experiences leave lasting epigenetic marks on immune cells. The discovery helps explain why people respond so differently to the same infections and could lead to more personalized [...]
Rejuvenating neurons restores learning and memory in mice
EPFL scientists report that briefly switching on three “reprogramming” genes in a small set of memory-trace neurons restored memory in aged mice and in mouse models of Alzheimer’s disease to level of healthy young [...]
New book from Nanoappsmedical Inc. – Global Health Care Equivalency
A new book by Frank Boehm, NanoappsMedical Inc. Founder. This groundbreaking volume explores the vision of a Global Health Care Equivalency (GHCE) system powered by artificial intelligence and quantum computing technologies, operating on secure [...]
