Researchers from King’s College London have shown that when brain cells are directly exposed to blood taken from COVID-19 patients with delirium, there is an increase in cell death and a decrease in the generation of new brain cells. Delirium represents a state of confusion indicating that, in these patients, the COVID-19 infection had impacted the brain.
Published in Molecular Psychiatry, the study’s findings indicate a key role for the inflammatory proteins (cytokines) produced by the immune system during infection, and could help inform potential treatments to reduce symptoms of confusion, disorientation and memory deficits in COVID-19 patients.
Dr. Alessandra Borsini, NIHR Maudsley BRC Senior Research Fellow, Institute of Psychiatry, Psychology & Neuroscience, first author, said, “More and more, research is indicating that there is a neurological element to severe COVID-19 infection, but we have little understanding about what happens in the brain to produce these symptoms. Our research is the first to use blood samples from COVID-19 patients experiencing delirium to investigate how the infection impacts a process called ‘neurogenesis’ (the generation of new brain cells), which is essential to maintain intact brain functions, including memory and thought processes.
“We have found that there is a profound reduction in the generation of new brain cells and an increase in cell death, and these are likely mechanisms behind delirium, and possibly other neurological symptoms, in COVID-19 patients.”
Previous research indicates that 20 to 30% of COVID-19 patients will develop neurological symptoms such as delirium, with rates of 60 to 70% in cases of severe illness. Delirium is a state of mental confusion that can happen if you become medically unwell and is associated with adverse outcomes, including prolonged hospitalization and death.
The development of neurological symptoms in COVID-19 patients is likely to involve an overactive immune response, called the cytokine storm, with an excessive production of these multiple inflammatory proteins. Once produced by the immune cells in the body in response to the infection, these cytokines can then move from the blood to the brain and directly affect brain mechanisms. However, which cytokines are directly relevant to the development of neurological symptoms is currently unknown.
The study collected serum samples from 36 patients admitted to Guy’s and St Thomas’ NHS Foundation Trust, in London, during the first wave of the COVID-19 pandemic in the UK (March-June 2020). Half of these patients were experiencing delirium symptoms whilst the other half did not present with these symptoms at time of hospital admission.
Researchers used a validated in vitro human cell model that consists of cells from the hippocampus, a part of the brain fundamental in many cognitive, memory and learning skills. Researchers treated cells from the hippocampus directly with the serum samples and observed the impacts on cell generation and death, as well as on the levels of different cytokines.
Results showed that treatment with serum taken from COVID-19 patients with delirium increased cell death and decreased generation of new brain cells. Investigation of the serum showed that those patients with delirium had higher levels of the cytokine IL6, while there was no difference between patients on other cytokines. Treating the brain cells with the serum did produce higher levels of two other cytokines—IL12 and IL13 –suggesting there is a process or cascade where IL12 and I1L3 are generated by brain cells in response to inflammation in the body created by IL6, and together they produce the delirium.
Author Professor Carmine Pariante, Professor of Biological Psychiatry at the Institute of Psychiatry Psychology & Neuroscience (IoPPN), and Consultant Perinatal Psychiatrist at South London and Maudsley NHS Foundation Trust, said, “The role of inflammation and our immune response in COVID-19 infection is well-known, but research like ours is now revealing how it affects our brain, our thinking and our mental health.
“Through a series of tests, we have shown that it is likely that the initial production of cytokine proteins as part of the inflammatory response in COVID-19 infection triggers a cascade of other cytokines which reduce generation of new brain cells and increase cell death, leading to brain symptoms such as delirium. These neurological symptoms are very concerning for patients and their families, and the hope is that our research can help identify which treatments would be most appropriate to lessen or prevent these symptoms.”
News
Why More People in Their 30s Are Suddenly Getting Colon Cancer
A major Swiss study found that colorectal cancer is becoming increasingly common in adults under 50, even as rates decline in older age groups. Researchers in Switzerland have identified a concerning trend: while colorectal [...]
Researchers Compare MS Models to Human Tissue in Search for Better Therapies
Researchers identified key differences between two widely used multiple sclerosis models, showing how each can better study myelin damage, immune responses, and repair. The findings may improve efforts to develop treatments that restore lost [...]
Scientists Discover Genetic “Off Switch” That Supercharges CAR T Cells Against Cancer
A new study reveals a possible way to make CAR T-cell therapy more durable and effective by targeting a single gene-regulating protein. CAR T-cell therapy is widely seen as a breakthrough in personalized cancer [...]
New Vitamin B12-Based Therapy Could Change How Brain Cancer Is Treated
Researchers have identified a vitamin B12–based compound that appears capable of crossing the blood–brain barrier and selectively accumulating in glioblastoma tissue. For decades, one of the biggest problems in brain cancer treatment has had [...]
Simple Fiber Supplement Cuts Knee Arthritis Pain in Just 6 Weeks, Study Finds
A daily inulin supplement may help reduce knee osteoarthritis pain while revealing a possible link between gut health, muscle function, and pain sensitivity. For millions of people living with knee osteoarthritis, managing chronic pain [...]
This Common Vitamin May Help Stop Prediabetes From Turning Into Diabetes
Vitamin D may help prevent type 2 diabetes in people with specific genetic variations, offering a possible path toward personalized diabetes prevention. More than 40% of U.S. adults have prediabetes, a condition in which [...]
Ebola, hantavirus: Is the world prepared for the next pandemic?
Funding cuts to health research and a growing antivaccine movement are making it harder than ever to respond to viruses. The World Health Organization (WHO) has declared that an Ebola outbreak in Uganda and [...]
May 2026 Healthcare News and Trends: Market Signals That Matter
Artificial intelligence is dominating headlines, telehealth has settled into a new normal, and digital health continues to promise transformation. However, much of what is being discussed in healthcare today reflects potential rather than reality. [...]
Scientists Rewire Donor Stem Cells To Outsmart Aggressive Blood Cancers
Researchers have tested a gene-edited stem cell transplant designed to shield healthy blood-forming cells from powerful cancer-targeting immunotherapies. For patients with highly aggressive blood cancers, stem cell transplantation can offer a rare chance at [...]
Recent Digital Health Trends, Insights and News – May 2026
Last month marked continued progress as digital health moves into its next phase — from AI expanding into drug discovery and core infrastructure to new federal pathways accelerating device access and home-based care. Together, [...]
Cancer Mystery Solved: Scientists Discover How Melanoma Becomes “Immortal”
Scientists have uncovered a previously overlooked mechanism that may help melanoma cells become effectively “immortal.” Cancer cells face a major problem before they can become deadly: They have to figure out how to stop [...]
How Visual Neurons Organize Thousands of Synaptic Inputs
Summary: A new study uncovered the organizational rules that determine how neurons in the primary visual cortex process information. By imaging both the cell bodies (soma) and the individual synapses (on dendritic spines) of [...]
Scientists Just Found a Surprising Way To Destroy “Forever Chemicals”
Scientists have uncovered a new mechanism that may help break down highly persistent PFAS pollutants. PFAS have earned the nickname “forever chemicals” for a reason. These industrial compounds are so chemically durable that they [...]
Scientists Discover Cheap Material That Kills Deadly Superbugs
A new sulfur-rich antimicrobial polymer shows strong effectiveness against fungal and bacterial pathogens and may offer an affordable solution to antimicrobial resistance. Antimicrobial resistance is creating growing challenges for both healthcare and food production, [...]
What to Know About Cicada, or BA.3.2, the Latest SARS-CoV-2 Variant Under Monitoring
Like periodical cicadas, the insects for which it is nicknamed, SARS-CoV-2 Omicron subvariant BA.3.2 is only just beginning to emerge after lying low for an extended period since it first appeared. Although it was [...]
Scientists Say This Simple Supplement May Actually Reverse Heart Disease
Scientists in Japan say a common supplement may actually help “unclog” certain diseased heart arteries from the inside out. A simple food supplement sold in Japan may have helped reverse a dangerous form of [...]
