Vanderbilt researchers are bolstering the fight against cancer with technology that enhances the effectiveness of T cells that attack tumors. The cutting-edge research was recently published in the journal Science Immunology.
Cancers co-opt both the immune and cardiovascular systems to fuel their own growth, researchers say. They do this in part by forming new blood vessels that provide essential nutrients to rapidly dividing cancer cells. T cells in the immune system also use blood vessels as conduits for finding and invading tumors. But vessels in tumors are often abnormal and put up barricades that impede the ability of T cells to locate and kill cancer cells.
However, using a nanotechnology invented in the Immunoengineering Lab at Vanderbilt, researchers discovered they could reverse—or normalize—the malformed tumor vasculature by activating the stimulator of interferon genes (STING) pathway, a component of the immune system that plays an important role in protecting against pathogen infection and the development of cancers.
John T. Wilson, associate professor of chemical and biomolecular engineering at Vanderbilt and a corresponding author on the paper, said that the ability of the technology to reprogram the vasculature of tumors can help make T cells more effective at eradicating cancer cells.
“This allowed T cells to better infiltrate and destroy tumors in mouse models of kidney and breast cancer and enhanced the efficacy of immunotherapies that are currently being used in patients,” said Wilson, who is also Principal Investigator of the Immunoengineering Lab and a Chancellor Faculty Fellow.
In the publication, researchers also discuss testing their STING-activating nanoparticle (STAN) technology on tumors that had been surgically removed from patients with renal cell carcinoma (RCC). Consistent with findings from their experiments with mice, they found that STANs “demonstrated superior immunostimulatory activity,” offering “initial evidence supporting the potential use of STANs as a strategy to coordinate antitumor innate immunity and vascular remodeling in human RCC.”
Such breakthroughs are needed. This year, nearly two million new cancer cases and more than 600,000 cancer deaths are projected to occur in the United States, according to the American Cancer Society.
“While this technology isn’t yet ready for use in cancer patients, our study revealed an exciting new strategy for improving responses to cancer immunotherapy,” said Wilson.

News
Does Space-Time Really Exist?
Is time something that flows — or just an illusion? Exploring space-time as either a fixed “block universe” or a dynamic fabric reveals deeper mysteries about existence, change, and the very nature of reality. [...]
Unlocking hidden soil microbes for new antibiotics
Most bacteria cannot be cultured in the lab-and that's been bad news for medicine. Many of our frontline antibiotics originated from microbes, yet as antibiotic resistance spreads and drug pipelines run dry, the soil [...]
By working together, cells can extend their senses beyond their direct environment
The story of the princess and the pea evokes an image of a highly sensitive young royal woman so refined, she can sense a pea under a stack of mattresses. When it comes to [...]
Overworked Brain Cells May Hold the Key to Parkinson’s
Scientists at Gladstone Institutes uncovered a surprising reason why dopamine-producing neurons, crucial for smooth body movements, die in Parkinson’s disease. In mice, when these neurons were kept overactive for weeks, they began to falter, [...]
Old tires find new life: Rubber particles strengthen superhydrophobic coatings against corrosion
Development of highly robust superhydrophobic anti-corrosion coating using recycled tire rubber particles. Superhydrophobic materials offer a strategy for developing marine anti-corrosion materials due to their low solid-liquid contact area and low surface energy. However, [...]
This implant could soon allow you to read minds
Mind reading: Long a science fiction fantasy, today an increasingly concrete scientific goal. Researchers at Stanford University have succeeded in decoding internal language in real time thanks to a brain implant and artificial intelligence. [...]
A New Weapon Against Cancer: Cold Plasma Destroys Hidden Tumor Cells
Cold plasma penetrates deep into tumors and attacks cancer cells. Short-lived molecules were identified as key drivers. Scientists at the Leibniz Institute for Plasma Science and Technology (INP), working with colleagues from Greifswald University Hospital and [...]
This Common Sleep Aid May Also Protect Your Brain From Alzheimer’s
Lemborexant and similar sleep medications show potential for treating tau-related disorders, including Alzheimer’s disease. New research from Washington University School of Medicine in St. Louis shows that a commonly used sleep medication can restore normal sleep patterns and [...]
Sugar-Coated Nanoparticles Boost Cancer Drug Efficacy
A team of researchers at the University of Mississippi has discovered that coating cancer treatment carrying nanoparticles in a sugar-like material increases their treatment efficacy. They reported their findings in Advanced Healthcare Materials. Over a tenth of breast [...]
Nanoparticle-Based Vaccine Shows Promise in Fighting Cancer
In a study published in OncoImmunology, researchers from the German Cancer Research Center and Heidelberg University have created a therapeutic vaccine that mobilizes the immune system to target cancer cells. The researchers demonstrated that virus peptides combined [...]
Quantitative imaging method reveals how cells rapidly sort and transport lipids
Lipids are difficult to detect with light microscopy. Using a new chemical labeling strategy, a Dresden-based team led by André Nadler at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and [...]
Ancient DNA reveals cause of world’s first recorded pandemic
Scientists have confirmed that the Justinian Plague, the world’s first recorded pandemic, was caused by Yersinia pestis, the same bacterium behind the Black Death. Dating back some 1,500 years and long described in historical texts but [...]
“AI Is Not Intelligent at All” – Expert Warns of Worldwide Threat to Human Dignity
Opaque AI systems risk undermining human rights and dignity. Global cooperation is needed to ensure protection. The rise of artificial intelligence (AI) has changed how people interact, but it also poses a global risk to human [...]
Nanomotors: Where Are They Now?
First introduced in 2004, nanomotors have steadily advanced from a scientific curiosity to a practical technology with wide-ranging applications. This article explores the key developments, recent innovations, and major uses of nanomotors today. A [...]
Study Finds 95% of Tested Beers Contain Toxic “Forever Chemicals”
Researchers found PFAS in 95% of tested beers, with the highest levels linked to contaminated local water sources. Per- and polyfluoroalkyl substances (PFAS), better known as forever chemicals, are gaining notoriety for their ability [...]
Long COVID Symptoms Are Closer To A Stroke Or Parkinson’s Disease Than Fatigue
When most people get sick with COVID-19 today, they think of it as a brief illness, similar to a cold. However, for a large number of people, the illness doesn't end there. The World [...]