For a third season, COVID-19 cases are rising ahead of the holidays, this time with a more recent variant driving infections.
Cases of JN. 1 infections rose from just more than 8% at the end of November to double digits by Dec. 9, according to CDC data.
International health experts say the sudden jump isn’t cause for concern—yet.
Here’s what you need to know:
What is JN.1?
The JN.1 variant is closely related to another omicron subvariant named BA.2.86, according to the CDC.
Health officials started tracking BA.2.86 in August but noticed some cases had a single change to the spike protein, the part of a virus that penetrates host cells to cause infection, according to the CDC.
JN.1 was first detected as its own variant in the United States in September, the CDC reported, and has since been identified in 11 countries.
The variant made up just 0.1% of cases at the end of October, according to CDC data, but that number has now increased exponentially.
“The continued growth of JN.1 suggests that it is either more transmissible or better at evading our immune systems,” the CDC said at the beginning of December.
This means the change to the spike protein may make it easier for the virus to get into cells than previous variants or make it harder for human immune systems to identify the virus as COVID-19.
International health experts also noted the trend, with JN.1 officially classified as its own variant by the World Health Organization on Dec. 19.
“Based on the available evidence, the additional global public health risk posed by JN.1 is currently evaluated as low,” the WHO said in a post on X, formerly known as Twitter. “Despite this, with the onset of winter in the Northern Hemisphere, JN.1 could increase the burden of respiratory infections in many countries.”
Does the updated COVID booster protect against JN.1?
The CDC says the JN.1 variant is closely related enough to previous variants that the updated COVID-19 booster shot will provide protection.
“The spike protein—called a ‘spike’ because it looks like tiny spikes on the virus’ surface—plays a crucial role in helping the virus infect people. Because of this, the spike protein is also the part of the virus that vaccines target, meaning vaccines should work against JN.1 and BA.2.86 similarly,” the CDC said.
The agency continued by saying it expects “treatments and testing to remain effective” against JN.1, in line with previous variants.
The most recent COVID-19 booster was approved by the Food and Drug Administration and then recommended by the CDC in September, but a large number of Americans have opted out of the shot.
Do I need the new COVID booster?
The vaccine is recommended for everyone over the age of six months, regardless of previous vaccine status, the CDC says.
Despite this, fewer and fewer Americans are adding the shot to their regular seasonal vaccines, like the flu shot.
By the middle of November, only 36 million adults and 3.5 million children had received the latest shot, equivalent to about 14% of the American public, ABC News reported.
That’s compared to the nearly 70% of Americans who completed the primary series of COVID-19 vaccines, McClatchy News reported.
Cases of JN.1 have seen some of the highest increases in Midwestern states, CDC data shows, correlating with a pocket of the U.S. that has been particularly hesitant to get the new shot.
Ahead of the holidays, the CDC reiterated the vaccine, masking and keeping your distance when you might be sick are still the most effective ways to prevent a COVID-19 infection and prevent its spread.
The agency said this also extends to other respiratory illnesses making the rounds this season.
“Many viruses spread more during the holiday season, so it is important to get all recommended vaccines, including flu, COVID-19 and RSV, as soon as possible,” the CDC said. “This will give you the best protection against these respiratory diseases, including while traveling and gathering with family and friends. These vaccines will also make your illness less severe if you do get sick.”
News
Concerning New Research Reveals Colon Cancer Is Skyrocketing in Adults Under 50
Colorectal cancer is striking younger adults at alarming rates, driven by lifestyle and genetic factors. Colorectal cancer (CRC) develops when abnormal cells grow uncontrollably in the colon or rectum, forming tumors that can eventually [...]
Scientists Discover a Natural, Non-Addictive Way To Block Pain That Could Replace Opioids
Scientists have discovered that the body can naturally dull pain through its own localized “benzodiazepine-like” peptides. A groundbreaking study led by a University of Leeds scientist has unveiled new insights into how the body manages pain, [...]
GLP-1 Drugs Like Ozempic Work, but New Research Reveals a Major Catch
Three new Cochrane reviews find evidence that GLP-1 drugs lead to clinically meaningful weight loss, though industry-funded studies raise concerns. Three new reviews from Cochrane have found that GLP-1 medications can lead to significant [...]
How a Palm-Sized Laser Could Change Medicine and Manufacturing
Researchers have developed an innovative and versatile system designed for a new generation of short-pulse lasers. Lasers that produce extremely short bursts of light are known for their remarkable precision, making them indispensable tools [...]
New nanoparticles stimulate the immune system to attack ovarian tumors
Cancer immunotherapy, which uses drugs that stimulate the body’s immune cells to attack tumors, is a promising approach to treating many types of cancer. However, it doesn’t work well for some tumors, including ovarian [...]
New Drug Kills Cancer 20,000x More Effectively With No Detectable Side Effects
By restructuring a common chemotherapy drug, scientists increased its potency by 20,000 times. In a significant step forward for cancer therapy, researchers at Northwestern University have redesigned the molecular structure of a well-known chemotherapy drug, greatly [...]
Lipid nanoparticles discovered that can deliver mRNA directly into heart muscle cells
Cardiovascular disease continues to be the leading cause of death worldwide. But advances in heart-failure therapeutics have stalled, largely due to the difficulty of delivering treatments at the cellular level. Now, a UC Berkeley-led [...]
The basic mechanisms of visual attention emerged over 500 million years ago, study suggests
The brain does not need its sophisticated cortex to interpret the visual world. A new study published in PLOS Biology demonstrates that a much older structure, the superior colliculus, contains the necessary circuitry to perform the [...]
AI Is Overheating. This New Technology Could Be the Fix
Engineers have developed a passive evaporative cooling membrane that dramatically improves heat removal for electronics and data centers Engineers at the University of California San Diego have created an innovative cooling system designed to greatly enhance [...]
New nanomedicine wipes out leukemia in animal study
In a promising advance for cancer treatment, Northwestern University scientists have re-engineered the molecular structure of a common chemotherapy drug, making it dramatically more soluble and effective and less toxic. In the new study, [...]
Mystery Solved: Scientists Find Cause for Unexplained, Deadly Diseases
A study reveals that a protein called RPA is essential for maintaining chromosome stability by stimulating telomerase. New findings from the University of Wisconsin-Madison suggest that problems with a key protein that helps preserve chromosome stability [...]
Nanotech Blocks Infection and Speed Up Chronic Wound Recovery
A new nanotech-based formulation using quercetin and omega-3 fatty acids shows promise in halting bacterial biofilms and boosting skin cell repair. Scientists have developed a nanotechnology-based treatment to fight bacterial biofilms in wound infections. The [...]
Researchers propose five key questions for effective adoption of AI in clinical practice
While Artificial Intelligence (AI) can be a powerful tool that physicians can use to help diagnose their patients and has great potential to improve accuracy, efficiency and patient safety, it has its drawbacks. It [...]
Advancements and clinical translation of intelligent nanodrugs for breast cancer treatment
A comprehensive review in "Biofunct. Mater." meticulously details the most recent advancements and clinical translation of intelligent nanodrugs for breast cancer treatment. This paper presents an exhaustive overview of subtype-specific nanostrategies, the clinical benefits [...]
It’s Not “All in Your Head”: Scientists Develop Revolutionary Blood Test for Chronic Fatigue Syndrome
A 96% accurate blood test for ME/CFS could transform diagnosis and pave the way for future long COVID detection. Researchers from the University of East Anglia and Oxford Biodynamics have created a highly accurate [...]
How Far Can the Body Go? Scientists Find the Ultimate Limit of Human Endurance
Even the most elite endurance athletes can’t outrun biology. A new study finds that humans hit a metabolic ceiling at about 2.5 times their resting energy burn. When ultra-runners take on races that last [...]















