“System 0” represents an emerging cognitive tool powered by AI that works alongside human intuition and analysis to enhance cognitive abilities.
This new system promises to support complex decision-making and problem-solving but requires careful management to avoid overreliance and ensure ethical use.
Introducing System 0
The growing interaction between humans and artificial intelligence (AI) is shaping a new way of thinking, known as System 0. This new cognitive framework exists outside the human mind but has the potential to enhance our cognitive abilities. System 0 works alongside the two established models of human thought: System 1, which is fast, intuitive, and automatic, and System 2, which is slower, more analytical, and reflective.
However, System 0 introduces an additional layer of complexity, reshaping the cognitive landscape in which we operate. This could represent a significant leap forward in how we think and make decisions. It is essential that we use this progress to strengthen our cognitive autonomy, ensuring we do not become overly reliant on AI.
This groundbreaking concept is detailed today (October 22) in the journal Nature Human Behaviour in an article titled “The Case for Human-AI Interaction as System 0 Thinking.” The article is authored by a team of researchers led by Professor Giuseppe Riva, director of the Humane Technology Lab at Università Cattolica’s Milan campus and the Applied Technology for Neuropsychology Lab at Istituto Auxologico Italiano IRCCS in Milan, and Professor Mario Ubiali from Università Cattolica’s Brescia campus. The study was conducted in collaboration with Massimo Chiriatti from Lenovo’s Infrastructure Solutions Group in Milan, Professor Marianna Ganapini from Union College in Schenectady, New York, and Professor Enrico Panai from Università Cattolica’s Milan campus.
External Cognitive Support Systems
Just as an external drive allows us to store data that are not present on the computer, we can work by connecting our drive to a PC wherever we are, artificial intelligence, with its galactic processing and data-handling capabilities, can represent an external circuit to the human brain capable of enhancing it. Hence the idea of System 0, which is essentially a form of “external” thinking that relies on the capabilities of AI.
By managing enormous amounts of data, AI can process information and provide suggestions or decisions based on complex algorithms. However, unlike intuitive or analytical thinking, System 0 does not assign intrinsic meaning to the information it processes. In other words, AI can perform calculations, make predictions, and generate responses without truly “understanding” the content of the data it works with.
Humans, therefore, have to interpret on their ones and giving meaning to the results produced by AI. It’s like having an assistant that efficiently gathers, filters, and organizes information but still requires our intervention to make informed decisions. This cognitive support provides valuable input, but the final control must always remain in human hands.
The Risks of Overreliance on AI
“The risk,” professors Riva and Ubiali emphasize, “is relying too much on System 0 without exercising critical thinking. If we passively accept the solutions offered by AI, we might lose our ability to think autonomously and develop innovative ideas. In an increasingly automated world, it is crucial that humans continue to question and challenge the results generated by AI,” the experts stress.
Furthermore, transparency and trust in AI systems represent another major dilemma. How can we be sure that these systems are free from bias or distortion and that they provide accurate and reliable information? “The growing trend of using synthetic or artificially generated data could compromise our perception of reality and negatively influence our decision-making processes,” the professors warn.
AI could even hijack our introspective abilities, they note—i.e., the act of reflecting on one’s thoughts and feelings—a uniquely human process. However, with AI’s advancement, it may become possible to rely on intelligent systems to analyze our behaviors and mental states. This raises the question: to what extent can we truly understand ourselves through AI analysis? And can AI replicate the complexity of subjective experience?
The Future of Cognitive Enhancement
Despite these questions, System 0 also offers enormous opportunities, the professors point out. Thanks to its ability to process complex data quickly and efficiently, AI can support humanity in tackling problems that exceed our natural cognitive capacities. Whether solving complex scientific issues, analyzing massive datasets, or managing intricate social systems, AI could become an indispensable ally.
To leverage the potential of System 0, the study’s authors suggest it is urgent to develop ethical and responsible guidelines for its use. “Transparency, accountability, and digital literacy are key elements to enable people to critically interact with AI,” they warn. “Educating the public on how to navigate this new cognitive environment will be crucial to avoid the risks of excessive dependence on these systems.”
The Future of Human Thought
They conclude: If left unchecked, System 0 could interfere with human thinking in the future. “It is essential that we remain aware and critical in how we use it; the true potential of System 0 will depend on our ability to guide it in the right direction.”
Reference: “The case for human–AI interaction as system 0 thinking” by Massimo Chiriatti, Marianna Ganapini, Enrico Panai, Mario Ubiali and Giuseppe Riva, 22 October 2024, Nature Human Behaviour.
DOI: 10.1038/s41562-024-01995-5

News
How the FDA opens the door to risky chemicals in America’s food supply
Lining the shelves of American supermarkets are food products with chemicals linked to health concerns. To a great extent, the FDA allows food companies to determine for themselves whether their ingredients and additives are [...]
Superbug crisis could get worse, killing nearly 40 million people by 2050
The number of lives lost around the world due to infections that are resistant to the medications intended to treat them could increase nearly 70% by 2050, a new study projects, further showing the [...]
How Can Nanomaterials Be Programmed for Different Applications?
Nanomaterials are no longer just small—they are becoming smart. Across fields like medicine, electronics, energy, and materials science, researchers are now programming nanomaterials to behave in intentional, responsive ways. These advanced materials are designed [...]
Microplastics Are Invading Our Arteries, and It Could Be Increasing Your Risk of Stroke
Higher levels of micronanoplastics were found in carotid artery plaque, especially in people with stroke symptoms, suggesting a potential new risk factor. People with plaque buildup in the arteries of their neck have been [...]
Gene-editing therapy shows early success in fighting advanced gastrointestinal cancers
Researchers at the University of Minnesota have completed a first-in-human clinical trial testing a CRISPR/Cas9 gene-editing technique to help the immune system fight advanced gastrointestinal (GI) cancers. The results, recently published in The Lancet Oncology, show encouraging [...]
Engineered extracellular vesicles facilitate delivery of advanced medicines
Graphic abstract of the development of VEDIC and VFIC systems for high efficiency intracellular protein delivery in vitro and in vivo. Credit: Nature Communications (2025). DOI: 10.1038/s41467-025-59377-y. https://www.nature.com/articles/s41467-025-59377-y Researchers at Karolinska Institutet have developed a technique [...]
Brain-computer interface allows paralyzed users to customize their sense of touch
University of Pittsburgh School of Medicine scientists are one step closer to developing a brain-computer interface, or BCI, that allows people with tetraplegia to restore their lost sense of touch. While exploring a digitally [...]
Scientists Flip a Gut Virus “Kill Switch” – Expose a Hidden Threat in Antibiotic Treatment
Scientists have long known that bacteriophages, viruses that infect bacteria, live in our gut, but exactly what they do has remained elusive. Researchers developed a clever mouse model that can temporarily eliminate these phages [...]
Enhanced Antibacterial Polylactic Acid-Curcumin Nanofibers for Wound Dressing
Background Wound healing is a complex physiological process that can be compromised by infection and impaired tissue regeneration. Conventional dressings, typically made from natural fibers such as cotton or linen, offer limited functionality. Nanofiber [...]
Global Nanomaterial Regulation: A Country-by-Country Comparison
Nanomaterials are materials with at least one dimension smaller than 100 nanometres (about 100,000 times thinner than a human hair). Because of their tiny size, they have unique properties that can be useful in [...]
Pandemic Potential: Scientists Discover 3 Hotspots of Deadly Emerging Disease in the US
Virginia Tech researchers discovered six new rodent carriers of hantavirus and identified U.S. hotspots, highlighting the virus’s adaptability and the impact of climate and ecology on its spread. Hantavirus recently drew public attention following reports [...]
Studies detail high rates of long COVID among healthcare, dental workers
Researchers have estimated approximately 8% of Americas have ever experienced long COVID, or lasting symptoms, following an acute COVID-19 infection. Now two recent international studies suggest that the percentage is much higher among healthcare workers [...]
Melting Arctic Ice May Unleash Ancient Deadly Diseases, Scientists Warn
Melting Arctic ice increases human and animal interactions, raising the risk of infectious disease spread. Researchers urge early intervention and surveillance. Climate change is opening new pathways for the spread of infectious diseases such [...]
Scientists May Have Found a Secret Weapon To Stop Pancreatic Cancer Before It Starts
Researchers at Cold Spring Harbor Laboratory have found that blocking the FGFR2 and EGFR genes can stop early-stage pancreatic cancer from progressing, offering a promising path toward prevention. Pancreatic cancer is expected to become [...]
Breakthrough Drug Restores Vision: Researchers Successfully Reverse Retinal Damage
Blocking the PROX1 protein allowed KAIST researchers to regenerate damaged retinas and restore vision in mice. Vision is one of the most important human senses, yet more than 300 million people around the world are at [...]
Differentiating cancerous and healthy cells through motion analysis
Researchers from Tokyo Metropolitan University have found that the motion of unlabeled cells can be used to tell whether they are cancerous or healthy. They observed malignant fibrosarcoma [...]