Young researchers from Siberian Federal University (SibFU) along with their colleagues from FRC KSC SB RAS are designing a technology for producing multilayer gilded nanodisks for targeted drug delivery and treating cancer using dip pen nanolithography (DPN).
“Magnetic nanodiscs coated with gold are in high demand in Biology and Medicine. They can be successfully used for magnetically induced apoptosis (the process of programmed cell death) and mechanical destruction of cell membranes. Nanodiscs can be ‘programmed’ to deliver drugs exclusively to diseased organs and tissues, and they can also mechanically destroy target cells (for example, malignant tumor cells). To place the nanodisks into the human body, they need to be ‘dressed’ in a special coating that will reduce the toxicity of our agents, prevent their early degradation in the body and allow them to ‘increase’ the aptamers on them for targeted delivery of medicines. Therefore, the structure of the disks is multi-layered and consists of a ferromagnetic metal coated with gold. Nowadays, a high-vacuum deposition method is used in combination with lithography methods and chemical etching processes to obtain such nanodisks, which determine the shape and size of the final product,” — says Anna Lukjanenko, the assistant of the specialized department of Solid State Physics and Nanotechnology at Siberian Federal University, scientist of Kirensky Institute of Physics SB RAS.
To yield nanoparticles with a large range of sizes and shapes and strict control of their parameters for producing disks for medical needs, university researchers are developing more cost-effective and adaptable technology compared to the current one.
“We want to improve the technology of dip pen nanolithography so that multilayer thin films of metals can be used as substrates. Then, dip pen nanolithography will help us produce precisely those nanodisks which are required by the medical research groups involved in introducing new treatment methods (for example, researchers from Krasnoyarsk State Medical University named after Professor V. F. Voino-Yasenetsky). Also, this method can be implemented in almost any production such as a plant and or a research center,” — the scientist said.
![](https://www.nanoappsmedical.com/wp-content/uploads/2017/05/spacer.jpg)
News This Week
Breakthrough in Antimicrobial Technology with Cinnamon-Based Nanokiller
The need for innovative antimicrobial agents has become increasingly urgent due to the rise of antibiotic-resistant pathogens and the persistent threat of infections acquired during hospital stays. Traditional antibiotics and antiseptics are often ineffective [...]
The Silent Battle Within: How Your Organs Choose Between Mom and Dad’s Genes
Research reveals that selective expression of maternal or paternal X chromosomes varies by organ, driven by cellular competition. A new study published today (July 26) in Nature Genetics by the Lymphoid Development Group at the MRC [...]
Study identifies genes increasing risk of severe COVID-19
Whether or not a person becomes seriously ill with COVID-19 depends, among other things, on genetic factors. With this in mind, researchers from the University Hospital Bonn (UKB) and the University of Bonn, in [...]
Small regions of the brain can take micro-naps while the rest of the brain is awake and vice versa
Sleep and wake: They're totally distinct states of being that define the boundaries of our daily lives. For years, scientists have measured the difference between these instinctual brain processes by observing brain waves, with [...]
Redefining Consciousness: Small Regions of the Brain Can Take Micro-Naps While the Rest of the Brain Is Awake
The study broadly reveals how fast brain waves, previously overlooked, establish fundamental patterns of sleep and wakefulness. Scientists have developed a new method to analyze sleep and wake states by detecting ultra-fast neuronal activity [...]
AI Reveals Health Secrets Through Facial Temperature Mapping
Researchers have found that different facial temperatures correlate with chronic illnesses like diabetes and high blood pressure, and these can be detected using AI with thermal cameras. They highlight the potential of this technology [...]
Breakthrough in aging research: Blocking IL-11 extends lifespan and improves health in mice
In a recent study published in the journal Nature, a team of researchers used murine models and various pharmacological and genetic approaches to examine whether pro-inflammatory signaling involving interleukin (IL)-11, which activates signaling molecules such [...]
Promise for a universal influenza vaccine: Scientists validate theory using 1918 flu virus
New research led by Oregon Health & Science University reveals a promising approach to developing a universal influenza vaccine—a so-called "one and done" vaccine that confers lifetime immunity against an evolving virus. The study, [...]
New Projects Aim To Pioneer the Future of Neuroscience
One study will investigate the alterations in brain activity at the cellular level caused by psilocybin, the psychoactive substance found in “magic mushrooms.” How do neurons respond to the effects of magic mushrooms? What [...]
Decoding the Decline: Scientific Insights Into Long COVID’s Retreat
Research indicates a significant reduction in long COVID risk, largely due to vaccination and the virus’s evolution. The study analyzes data from over 441,000 veterans, showing lower rates of long COVID among vaccinated individuals compared [...]
Silicon Transformed: A Breakthrough in Laser Nanofabrication
A new method enables precise nanofabrication inside silicon using spatial light modulation and laser pulses, creating advanced nanostructures for potential use in electronics and photonics. Silicon, the cornerstone of modern electronics, photovoltaics, and photonics, [...]
Caught in the actinium: New research could help design better cancer treatments
The element actinium was first discovered at the turn of the 20th century, but even now, nearly 125 years later, researchers still don't have a good grasp on the metal's chemistry. That's because actinium [...]
Innovative Light-Controlled Drugs Could Revolutionize Neuropathic Pain Treatment
A team of researchers from the Institute for Bioengineering of Catalonia (IBEC) has developed light-activated derivatives of the anti-epileptic drug carbamazepine to treat neuropathic pain. Light can be harnessed to target drugs to specific [...]
Green Gold: Turning E-Waste Into a Treasure Trove of Rare Earth Metals
Scientists are developing a process inspired by nature that efficiently recovers europium from old fluorescent lamps. The approach could lead to the long-awaited recycling of rare earth metals. A small molecule that naturally serves [...]
Cambridge Study: AI Chatbots Have an “Empathy Gap,” and It Could Be Dangerous
A new study suggests a framework for “Child Safe AI” in response to recent incidents showing that many children perceive chatbots as quasi-human and reliable. A study has indicated that AI chatbots often exhibit [...]
Nanoparticle-based delivery system could offer treatment for diabetics with rare insulin allergy
Up to 3% of people with diabetes have an allergic reaction to insulin. A team at Forschungszentrum Jülich has now studied a method that could be used to deliver the active substance into the [...]
Leave A Comment