Breast cancer in its various forms affects more than 250,000 Americans a year. One particularly aggressive and hard-to-treat type is triple-negative breast cancer (TNBC), which lacks specific receptors targeted by existing treatments. The rapid growth and metastasis of this cancer also make it challenging to manage, leading to limited therapy options and an often poor prognosis for patients.
“In this paper, we showed that we can use nanotubes to specifically target both proliferating and senescent TNBC cells with chemotherapeutics and senolytics, killing them without targeting healthy breast cells,” said Efie Kokkoli, professor of chemical and biomolecular engineering, a core researcher at the Johns Hopkins Institute for NanoBioTechnology, and a specialist in engineering targeted nanoparticles for the delivery of cancer therapeutics.
Senescent cancer cells are those that, after exposure to chemotherapy, stop multiplying and are resistant to further treatment. Senolytics are the medications that target and eliminate them.
To create the tubes, Kokkoli’s team used single-stranded DNA (ssDNA)-amphiphiles—structures that are designed to stick to molecules like water and can self-assemble into hollow nanotubes.
The team loaded the nanotubes with either the chemotherapeutic doxorubicin or the senolytic ABT-263. Nanotubes with ABT-263 effectively killed senescent cancer cells, making them more susceptible to further treatment from doxorubicin.
This new approach that combines the therapeutic properties of both chemotherapeutics and senolytics delivered through the novel DNA nanotubes has the potential to change how TNBC and other cancers are treated as it offers a direct way to fight resistant cancers, according to Kokkoli.
“Our ssDNA nanotubes are a promising delivery vehicle that could be used for targeted delivery of therapeutics to TNBC and other cancer cells, and even though we have not started this yet, the next logical step for us is to evaluate this delivery system in animal studies and evaluate them in a mouse model of TNBC,” Kokkoli said.
News
Cancer Mystery Solved: Scientists Discover How Melanoma Becomes “Immortal”
Scientists have uncovered a previously overlooked mechanism that may help melanoma cells become effectively “immortal.” Cancer cells face a major problem before they can become deadly: They have to figure out how to stop [...]
How Visual Neurons Organize Thousands of Synaptic Inputs
Summary: A new study uncovered the organizational rules that determine how neurons in the primary visual cortex process information. By imaging both the cell bodies (soma) and the individual synapses (on dendritic spines) of [...]
Scientists Just Found a Surprising Way To Destroy “Forever Chemicals”
Scientists have uncovered a new mechanism that may help break down highly persistent PFAS pollutants. PFAS have earned the nickname “forever chemicals” for a reason. These industrial compounds are so chemically durable that they [...]
Scientists Discover Cheap Material That Kills Deadly Superbugs
A new sulfur-rich antimicrobial polymer shows strong effectiveness against fungal and bacterial pathogens and may offer an affordable solution to antimicrobial resistance. Antimicrobial resistance is creating growing challenges for both healthcare and food production, [...]
What to Know About Cicada, or BA.3.2, the Latest SARS-CoV-2 Variant Under Monitoring
Like periodical cicadas, the insects for which it is nicknamed, SARS-CoV-2 Omicron subvariant BA.3.2 is only just beginning to emerge after lying low for an extended period since it first appeared. Although it was [...]
Scientists Say This Simple Supplement May Actually Reverse Heart Disease
Scientists in Japan say a common supplement may actually help “unclog” certain diseased heart arteries from the inside out. A simple food supplement sold in Japan may have helped reverse a dangerous form of [...]
New breakthrough against radiation: Korean Scientists create revolutionary shield with nanotechnology
Korean Scientists develop new nanotechnology material capable of reducing radiation impacts in space missions, hospitals, and power plants. The search for more efficient protection technologies in extreme environments has just gained an important advance. Korean [...]
Scientists Just Discovered the Hidden Trick That Keeps Your Cells Alive
A strange bead-like motion inside cells may be the secret to keeping their DNA—and health—in balance. Mitochondria are often described as the power plants of the cell because they produce the energy cells need [...]
Scientists Discover Stem Cells That Could Regrow Teeth and Bone
Scientists just uncovered the cellular “blueprint” that could one day let us regrow real teeth. Researchers at Science Tokyo have uncovered two distinct stem cell lineages that play a central role in forming tooth [...]
Scientists Uncover Fatal Weakness in “Zombie Cells” Linked to Cancer
A newly identified weakness in “zombie” cells may open the door to more precise cancer treatments by turning their own survival strategy against them. A new class of drugs takes advantage of a recently [...]
Bowel and Ovarian Cancers Are Dramatically Rising in Young Adults, Scientists Aren’t Sure Why
Cancer incidence is increasing, especially among younger adults, and current risk factors don’t fully account for the trend. Scientists suggest other underlying causes may be contributing. Cancer patterns in England are shifting in a [...]
New Immune Pathway Could Supercharge mRNA Cancer Vaccines
A surprising backup system in the immune response to mRNA vaccines may hold the key to more effective cancer treatments. The arrival of mRNA vaccines against SARS-CoV-2 in 2020 marked a turning point in the COVID-19 pandemic. Today, [...]
Scientists Discover “Molecular Switch” That Fuels Alzheimer’s Brain Inflammation
A newly identified trigger of brain inflammation could offer a fresh target for slowing Alzheimer’s progression. The brain has its own built-in immune system that identifies threats and responds to them. In Alzheimer’s disease, growing evidence [...]
Molecular Manufacturing: The Future of Nanomedicine – New book from NanoappsMedical Inc.
This book explores the revolutionary potential of atomically precise manufacturing technologies to transform global healthcare, as well as practically every other sector across society. This forward-thinking volume examines how envisaged Factory@Home systems might enable the cost-effective [...]
Forgotten Medicinal Plant Shows Promise in Fighting Dangerous Superbugs
A traditional medicinal plant, tormentil, shows promise against antibiotic-resistant bacteria in laboratory tests. Its compounds work by limiting bacterial growth and boosting antibiotic performance. Before the development of modern antibiotics, plant-based remedies were commonly [...]
NanoMedical Brain/Cloud Interface – Explorations and Implications. A new book from Frank Boehm
New book from Frank Boehm, NanoappsMedical Inc Founder: This book explores the future hypothetical possibility that the cerebral cortex of the human brain might be seamlessly, safely, and securely connected with the Cloud via [...]
