Nanodiamonds as platform for therapy and diagnosis of brain diseases
The blood-brain barrier is a physiological boundary layer that works highly selectively and thus protects the brain: On the one hand, pathogens or toxins are effectively prevented from penetrating the brain, on the other hand, however, necessary messengers and nutrients can pass through them unhindered. This selectivity makes it difficult for physicians to examine or treat the brain because drugs or contrast agents for imaging procedures cannot overcome the barrier.
Scientists led by Dr. Jana Hedrich, Prof. Dr. Heiko Luhmann and Prof. Dr. Tanja Weil, in cooperation with the University of Ulm and the University Medical Center of the Johannes Gutenberg University in Mainz have now investigated the suitability of a system based on nanodiamonds as diagnostic and therapeutic method.
Nano-diamonds with a size in the range of a millionth of a meter have the advantage of high biocompatibility: they are not degradable for the body, should be well tolerated and are therefore potentially suitable for both diagnostic and therapeutic purposes.
For their research, the scientists have modified the diamonds in two ways: A coating with a biopolymer based on the most abundant protein in human blood, “serum albumin”, enables the diamonds to be absorbed into the brain and later to be combined with drugs.
“Diamonds are chemically non-reactive, which means that it is difficult to bind drug molecules,” says Jana Hedrich and Tanja Weil. “The albumin coating enables us to create a stable coating and bind almost any medication to it.”
As a further modification, a defect was specifically introduced into the diamond by replacing an atom in the diamond, which consisting of carbon, with a nitrogen atom. Furthermore, there is an empty space in the crystal directly next to this nitrogen atom.
“A diamond is normally very clear and, ideally, flawless – light can therefore easily pass through it,” explains Hedrich….
Image Credit: University Medical Center of the Johannes Gutenberg University in Main
C. diff might not originate from external transmission but rather from within the infected patient themselves. Hospital staff dedicate significant effort to safeguard patients from infections during their hospital stay. Through practices ranging from [...]
Google says it has made a significant step in identifying disease-causing genes, which could help spot rare genetic disorders. A new model named AlphaMissense is able to confidently classify 89 per cent of all [...]
MINDWATCH study reveals cognitive peaks with everyday pleasures. Listening to music and drinking coffee are the sorts of everyday pleasures that can impact a person’s brain activity in ways that improve cognitive performance, including [...]
Moderna has developed a new and improved version of its COVID-19 vaccine. The unique formulation (mRNA-1283) reduces the vaccine's content from the full-length SARS-CoV-2 spike protein to a narrowly focused encoding of just two [...]
Breast cancer in its various forms affects more than 250,000 Americans a year. One particularly aggressive and hard-to-treat type is triple-negative breast cancer (TNBC), which lacks specific receptors targeted by existing treatments. The rapid [...]
Scientists from Nanyang Technological University, Singapore (NTU Singapore) have created a process that can upcycle most plastics into chemical ingredients useful for energy storage, using light-emitting diodes (LEDs) and a commercially available catalyst, all [...]
The mere scent of seafood can severely sicken those allergic to it — and therefore they are more likely to avoid it. Similarly, individuals who experience food poisoning from a specific dish tend to [...]
Researchers in Germany and Japan have been able to increase the diffusion of magnetic whirls, so-called skyrmions, by a factor of ten. In today’s world, our lives are unimaginable without computers. Up until now, [...]
Omicron infections have a lower risk of long COVID than earlier variants, according to a study analyzing data from 11,000 participants. The risk of developing long COVID is significantly lower following an infection with [...]
Researchers have discovered that insulin resistance, typically linked with type 2 diabetes, is also present in cancer patients and can accelerate the spread of the disease. In the 1920s, scientists found that the urine [...]
Scientists from ETH Zurich and the University of Geneva have developed a new technique that allows them to observe chemical reactions taking place in liquids at extremely high temporal resolution. This innovation enables them to track how molecules [...]
Research published recently suggests that Pfizer’s erectile dysfunction drug Viagra can decrease the risk of developing Alzheimer’s disease by up to 69 percent. The research, which was published in Nature, found that the medication has [...]
An AI-powered model utilizes chest X-rays to help develop biomarkers for aging. What if determining “your age” was based on your chest rather than your face? Scientists from Osaka Metropolitan University have crafted an [...]
Cancer biomarkers circulating in body fluids can be used for diagnosis and treatment monitoring. However, current detection technology lacks the required sensitivity, limiting biomarker use in clinical applications. Colorectal cancer is the second most [...]
The findings could lead to a cure for LAM. Researchers from the University of Cincinnati may have identified a potential treatment for lymphangioleiomyomatosis (LAM), a rare lung condition resembling cancer found predominantly in women of reproductive [...]
You can adjust all of your cookie settings by navigating the tabs on the left hand side.
Strictly Necessary Cookies
Strictly Necessary Cookie should be enabled at all times so that we can save your preferences for cookie settings.
If you disable this cookie, we will not be able to save your preferences. This means that every time you visit this website you will need to enable or disable cookies again.
What Are Cookies
For more general information on cookies see the Wikipedia article on HTTP Cookies.
You can prevent the setting of cookies by adjusting the settings on your browser (see your browser Help for how to do this). Be aware that disabling cookies will affect the functionality of this and many other websites that you visit. Disabling cookies will usually result in also disabling certain functionality and features of the this site. Therefore it is recommended that you do not disable cookies.
The Cookies We Set
Site preferences cookies. In order to provide you with a great experience on this site we provide the functionality to set your preferences for how this site runs when you use it. In order to remember your preferences we need to set cookies so that this information can be called whenever you interact with a page is affected by your preferences.
Third Party Cookies
This site uses Google Analytics which is one of the most widespread and trusted analytics solutions on the web. It helps us to understand how you use the site and ways that we can improve your experience. These cookies may track things such as how long you spend on the site and the pages that you visit so we can continue to produce engaging content. For more information on Google Analytics cookies, see the official Google Analytics page.
Hopefully that has clarified things for you and as was previously mentioned if there is something that you aren’t sure whether you need or not it’s usually safer to leave cookies enabled in case it does interact with one of the features you use on our site.
However if you are still looking for more information then you can contact us through our preferred contact method: