When nanoparticles are used for drug delivery, they often end up in the liver or spleen instead of the intended target.
A team led by Jacob S. Brenner and Vladimir Muzykantov of the University of Pennsylvania now shows that nanocarrier delivery can be improved by the having the nanocarriers “hitchhike” on red blood cells (Nat. Commun. 2018, DOI: 10.1038/s41467-018-05079-7). The researchers withdrew red blood cells from mice and incubated them with nanoparticles, which adsorbed on the cell surface.
They then injected the cells back into the animals through arterial catheters. When injected this way, the nanocarriers accumulate in the first organ they encounter downstream from the injection site. The researchers think the narrow capillaries cause the nanoparticles to detach from the blood cells and transfer to the cells lining the capillaries.
Image Credit: Nat. Commun
News This Week
LAS CRUCES, N.M. — Members of an independent NASA safety panel said they were worried that the Oct. 11 Soyuz launch failure could make safety concerns with the agency's commercial crew program even worse. [...]
Canadian astronaut Col. Chris Hadfield (Ret.) on Friday said that human travel to space will happen sooner than we think, adding that the first destination will likely be a return trip to the moon. [...]
Antibody-based imaging of a particularly aggressive form of breast cancer is undergoing clinical trials worldwide, but the path from trial to application is being hampered by a major obstacle: safety. Concerns stem from inefficient [...]
Following the discovery of graphene in 2003, there has been considerable interest in other types of 2D materials. However, splitting a bulk crystal material into 2D flakes for use in electronics has proven hard [...]
The digital economy is set to unlock tremendous economic value for countries over time. But a common setback for the use of various new technologies is their vulnerability to hackers. That's because companies and [...]
Nanomedical Device and Systems Design: Challenges, Possibilities, Visions now available to rent on Kindle
To accommodate students who wish to read the book at an affordable cost, Nanomedical Device and Systems Design: Challenges, Possibilities, Visions by Frank Boehm (CEO NanoApps Medical Inc.) is available to rent on Kindle. This book benefits [...]
The last five years has seen a surge of attacks on the healthcare industry, with the largest breaches impacting as many as 80 million people. In July this year, it was revealed that 150,000 [...]