When nanoparticles are used for drug delivery, they often end up in the liver or spleen instead of the intended target.
A team led by Jacob S. Brenner and Vladimir Muzykantov of the University of Pennsylvania now shows that nanocarrier delivery can be improved by the having the nanocarriers “hitchhike” on red blood cells (Nat. Commun. 2018, DOI: 10.1038/s41467-018-05079-7). The researchers withdrew red blood cells from mice and incubated them with nanoparticles, which adsorbed on the cell surface.
They then injected the cells back into the animals through arterial catheters. When injected this way, the nanocarriers accumulate in the first organ they encounter downstream from the injection site. The researchers think the narrow capillaries cause the nanoparticles to detach from the blood cells and transfer to the cells lining the capillaries.
Image Credit: Nat. Commun
News This Week
New book from NanoappsMedical Inc – Molecular Manufacturing: The Future of Nanomedicine
This book explores the revolutionary potential of atomically precise manufacturing technologies to transform global healthcare, as well as practically every other sector across society. This forward-thinking volume examines how envisaged Factory@Home systems might enable the cost-effective [...]
Scientists Discover Simple Saliva Test That Reveals Hidden Diabetes Risk
Researchers have identified a potential new way to assess metabolic health using saliva instead of blood. High insulin levels in the blood, known as hyperinsulinemia, can reveal metabolic problems long before obvious symptoms appear. It is [...]
One Nasal Spray Could Protect Against COVID, Flu, Pneumonia, and More
A single nasal spray vaccine may one day protect against viruses, pneumonia, and even allergies. For decades, scientists have dreamed of creating a universal vaccine capable of protecting against many different pathogens. The idea [...]
New AI Model Predicts Cancer Spread With Incredible Accuracy
Scientists have developed an AI system that analyzes complex gene-expression signatures to estimate the likelihood that a tumor will spread. Why do some tumors spread throughout the body while others remain confined to their [...]
Scientists Discover DNA “Flips” That Supercharge Evolution
In Lake Malawi, hundreds of species of cichlid fish have evolved with astonishing speed, offering scientists a rare opportunity to study how biodiversity arises. Researchers have identified segments of “flipped” DNA that may allow fish to adapt rapidly [...]
Our books now available worldwide!
Online Sellers other than Amazon, Routledge, and IOPP Indigo Global Health Care Equivalency in the Age of Nanotechnology, Nanomedicine and Artifcial Intelligence Global Health Care Equivalency In The Age Of Nanotechnology, Nanomedicine And Artificial [...]
Scientists Discover Why Some COVID Survivors Still Can’t Taste Food Years Later
A new study provides the first direct biological evidence explaining why some people continue to experience taste loss long after recovering from COVID-19. Researchers have uncovered specific biological changes in taste buds that could help [...]
Catching COVID significantly raises the risk of developing kidney disease, researchers find
Catching Covid significantly raises the risk of developing deadly kidney disease, research has shown. The virus was found to increase the chances that patients will develop the incurable condition by around 50 per cent. [...]
Leave A Comment