Once cartilage is damaged, there is little that can be done to repair it. Unlike many other tissues, cartilage doesn’t heal well and consequences of injuries and disease can last a lifetime. Now researchers at Texas A&M University have developed an unusual new class of materials that may give cartilage a way of repairing itself.
The new materials are two dimensional nanosilicate disks that have a negative charge on their surface and a positive charge on the edges. Being only one atom thick and having a unique charge pattern lets these coin-shaped particles grab onto proteins and growth factors that they can then slowly release.
Lately, attempts at protein and growth factor therapies for cartilage repair have involved delivering large doses to patients, as these substances don’t stay around long enough for smaller doses to work. The new nanosilicate disks may overcome this problem by sticking around the treatment area for extended periods while slowly releasing the therapeutic molecules at a pre-determined rate.
While these disks have not been tried in patients, laboratory experiments have shown that they do trap proteins and growth factors and then release them slowly over a period of about a month. The disks are expected to break down as well when in the body, but at a somewhat slower rate, eventually exiting and hopefully not causing any complications.
Image Credit: Medgadget
News This Week
The incorporation of exotic DNA from wild relatives into wheat results in a remarkable yield increase of up to 50%, even in hot weather, surpassing elite lines without these genes. Amid a year of [...]
Australia has become the first country to recognise psychedelics as medicines, after the Therapeutic Goods Administration took researchers by surprise and approved the psychedelic substances in magic mushrooms and MDMA for use by people [...]
In a new study, scientists with the University of Florida have found that a combination of silver nanoparticles and antibiotics is effective against antibiotic-resistant bacteria. The researchers hope to turn this discovery into viable [...]
Peritoneal cancer is difficult to treat and has a poor survival prognosis. But a new and effective nanomedicine delivery system is offering some hope. The company is called NaDeNo and is well underway with [...]
According to a new study by researchers at Penn Medicine, ketamine, which is well-known as an anesthetic and is becoming increasingly popular as an antidepressant, dramatically reorganizes activity in the brain, almost as if [...]
A new immunotherapy releases cancer-killing cytokines only within the tumor. Researchers at the University of California San Francisco (UCSF) have developed a new T cell-based immunotherapy that selectively targets cancer cells, producing a powerful anti-cancer cytokine [...]
An AI was tasked with creating proteins with anti-microbial properties. Researchers then created a subset of the proteins and found some did the job. An AI has designed anti-microbial proteins that were then tested [...]
Treating cancer with combinations of drugs can be more effective than using a single drug. However, figuring out the optimal combination of drugs, and making sure that all of the drugs reach the right [...]
By one unique metric, we could approach technological singularity by the end of this decade, if not sooner. A translation company developed a metric, Time to Edit (TTE), to calculate the time it takes for professional [...]
Phase transition in early universe changes strength of interaction between dark and normal matter. Dark matter remains one of the greatest mysteries of modern physics. It is clear that it must exist, because without [...]
Summary: Researchers have developed a new family of nano-scale capsules capable of carrying CRISPR gene editing tools to different organs of the body before harmlessly dissolving. The capsules were able to enter the brains of [...]
An enzyme that defends human cells against viruses can help drive cancer evolution towards greater malignancy by causing myriad mutations in cancer cells, according to a study led by investigators at Weill Cornell Medicine. The [...]
Using a mouse model, Japanese researchers unleash the likely mechanism of action of Actinidia arguta (sarunashi) juice on lung cancer development. Lung cancer is a leading cause of death in Japan and across the [...]
When used as wearable medical devices, stretchy, flexible gas sensors can identify health conditions or issues by detecting oxygen or carbon dioxide levels in the breath or sweat. They also are useful for monitoring [...]
Novel drugs, such as vaccines against covid-19, among others, are based on drug transport using nanoparticles. Whether this drug transport is negatively influenced by an accumulation of blood proteins on the nanoparticle’s surface was [...]
The costly lesson from COVID: why elimination should be the default global strategy for future pandemics
Imagine it is 2030. Doctors in a regional hospital in country X note an expanding cluster of individuals with severe respiratory disease. Rapid whole-genome sequencing identifies the disease-causing agent as a novel coronavirus. Epidemiological [...]