Together with colleagues, a group of scientists from Immanuel Kant Baltic Federal University synthesized nanostructures of gold and iron oxides that have improved magnetic and optical properties because of their unique star shape. The particles obtained are safe for healthy human cells and can be used in tumor therapy. The results of the study are published in the journal ACS Applied Materials & Interfaces.
The optical properties help to visualize, that is, to track particles in the human body. It can be used for photothermal therapy, during which the cells are heated and destroyed by the light of a certain wavelength. These features can be used together to provide more effective destruction of cancer cells.
Together with international colleagues, scientists from the Scientific and Educational Center “Smart Materials and Biomedical Applications” (based on Immanuel Kant Baltic Federal University, Kaliningrad), synthesized nanostructures containing gold and iron oxides, which can be used in photothermal and magneto-mechanical cancer therapy.
Researchers studied the structure of the resulting particles. The latter were star-shaped and had a core of gold, surrounded by an iron oxide sheath. The scientists proved that the shape and optical response of the particles were excellent for combined cancer therapy.
Moreover, the scientists tested how the particles affect breast cancer cells and cell culture, blood vessel walls are normally formed. The cells were pre-incubated in a culture medium with predetermined concentrations of nanoparticles.
It turned out that the nanoparticles had good biocompatibility—they had low toxicity and did not affect the viability of healthy cells. At the same time, the viability of cancer cells with nanostructures was reduced by 65% after the influence of a variable magnetic field of low frequency. When exposed to light, the viability of cancer cells was reduced by 45% due to the local heating of the nanoparticles. The effectiveness of the approach was also confirmed by morphological changes in cancer cells, including their “shrinkage” after alternating magnetic field or light therapy.
“The purpose of this study was to develop and test multifunctional nanoparticles with special magnetic and optical properties. In biomedicine, such nanoparticles are a promising material for cancer treatment. That’s why in this article we showed not only the detailed characterization of the physicochemical properties of the obtained samples. We also added the results of cytotoxicity upon application of various external stimuli (optical radiation and magnetic field), and showed the effectiveness of both approaches,” says Alexander Omelyanchik, a researcher at the Scientific and Educational Center “Smart Materials and Biomedical Applications” (based on Immanuel Kant Baltic Federal University, Kaliningrad).

News
Does Space-Time Really Exist?
Is time something that flows — or just an illusion? Exploring space-time as either a fixed “block universe” or a dynamic fabric reveals deeper mysteries about existence, change, and the very nature of reality. [...]
Unlocking hidden soil microbes for new antibiotics
Most bacteria cannot be cultured in the lab-and that's been bad news for medicine. Many of our frontline antibiotics originated from microbes, yet as antibiotic resistance spreads and drug pipelines run dry, the soil [...]
By working together, cells can extend their senses beyond their direct environment
The story of the princess and the pea evokes an image of a highly sensitive young royal woman so refined, she can sense a pea under a stack of mattresses. When it comes to [...]
Overworked Brain Cells May Hold the Key to Parkinson’s
Scientists at Gladstone Institutes uncovered a surprising reason why dopamine-producing neurons, crucial for smooth body movements, die in Parkinson’s disease. In mice, when these neurons were kept overactive for weeks, they began to falter, [...]
Old tires find new life: Rubber particles strengthen superhydrophobic coatings against corrosion
Development of highly robust superhydrophobic anti-corrosion coating using recycled tire rubber particles. Superhydrophobic materials offer a strategy for developing marine anti-corrosion materials due to their low solid-liquid contact area and low surface energy. However, [...]
This implant could soon allow you to read minds
Mind reading: Long a science fiction fantasy, today an increasingly concrete scientific goal. Researchers at Stanford University have succeeded in decoding internal language in real time thanks to a brain implant and artificial intelligence. [...]
A New Weapon Against Cancer: Cold Plasma Destroys Hidden Tumor Cells
Cold plasma penetrates deep into tumors and attacks cancer cells. Short-lived molecules were identified as key drivers. Scientists at the Leibniz Institute for Plasma Science and Technology (INP), working with colleagues from Greifswald University Hospital and [...]
This Common Sleep Aid May Also Protect Your Brain From Alzheimer’s
Lemborexant and similar sleep medications show potential for treating tau-related disorders, including Alzheimer’s disease. New research from Washington University School of Medicine in St. Louis shows that a commonly used sleep medication can restore normal sleep patterns and [...]
Sugar-Coated Nanoparticles Boost Cancer Drug Efficacy
A team of researchers at the University of Mississippi has discovered that coating cancer treatment carrying nanoparticles in a sugar-like material increases their treatment efficacy. They reported their findings in Advanced Healthcare Materials. Over a tenth of breast [...]
Nanoparticle-Based Vaccine Shows Promise in Fighting Cancer
In a study published in OncoImmunology, researchers from the German Cancer Research Center and Heidelberg University have created a therapeutic vaccine that mobilizes the immune system to target cancer cells. The researchers demonstrated that virus peptides combined [...]
Quantitative imaging method reveals how cells rapidly sort and transport lipids
Lipids are difficult to detect with light microscopy. Using a new chemical labeling strategy, a Dresden-based team led by André Nadler at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and [...]
Ancient DNA reveals cause of world’s first recorded pandemic
Scientists have confirmed that the Justinian Plague, the world’s first recorded pandemic, was caused by Yersinia pestis, the same bacterium behind the Black Death. Dating back some 1,500 years and long described in historical texts but [...]
“AI Is Not Intelligent at All” – Expert Warns of Worldwide Threat to Human Dignity
Opaque AI systems risk undermining human rights and dignity. Global cooperation is needed to ensure protection. The rise of artificial intelligence (AI) has changed how people interact, but it also poses a global risk to human [...]
Nanomotors: Where Are They Now?
First introduced in 2004, nanomotors have steadily advanced from a scientific curiosity to a practical technology with wide-ranging applications. This article explores the key developments, recent innovations, and major uses of nanomotors today. A [...]
Study Finds 95% of Tested Beers Contain Toxic “Forever Chemicals”
Researchers found PFAS in 95% of tested beers, with the highest levels linked to contaminated local water sources. Per- and polyfluoroalkyl substances (PFAS), better known as forever chemicals, are gaining notoriety for their ability [...]
Long COVID Symptoms Are Closer To A Stroke Or Parkinson’s Disease Than Fatigue
When most people get sick with COVID-19 today, they think of it as a brief illness, similar to a cold. However, for a large number of people, the illness doesn't end there. The World [...]