Melanoma in skin biopsy with H&E stain — this case may represent superficial spreading melanoma. Credit: Wikipedia/CC BY-SA 3.0
Researchers at Tel Aviv University have developed a novel nano-vaccine for melanoma, the most aggressive type of skin cancer. Their innovative approach has so far proven effective in preventing the development of melanoma in mouse models and in treating primary tumors and metastases that result from melanoma.
The focus of the research is on a nanoparticle that serves as the basis for the new vaccine. The study was led by Prof. Ronit Satchi-Fainaro, chair of the Department of Physiology and Pharmacology and head of the Laboratory for Cancer Research and Nanomedicine at TAU’s Sackler Faculty of Medicine, and Prof. Helena Florindo of the University of Lisbon while on sabbatical at the Satchi-Fainaro lab at TAU; it was conducted by Dr. Anna Scomparin of Prof. Satchi-Fainaro’s TAU lab, and postdoctoral fellow Dr. João Conniot. The results were published on August 5 in Nature Nanotechnology.
Melanoma develops in the skin cells that produce melanin or skin pigment. “The war against cancer in general, and melanoma in particular, has advanced over the years through a variety of treatment modalities, such as chemotherapy, radiation therapy and immunotherapy; but the vaccine approach, which has proven so effective against various viral diseases, has not materialized yet against cancer,” says Prof. Satchi-Fainaro. “In our study, we have shown for the first time that it is possible to produce an effective nano-vaccine against melanoma and to sensitize the immune system to immunotherapies.”
The researchers harnessed tiny particles, about 170 nanometers in size, made of a biodegradable polymer. Within each particle, they “packed” two peptides—short chains of amino acids, which are expressed in melanoma cells. They then injected the nanoparticles (or “nano-vaccines”) into a mouse model bearing melanoma.
Image Credit: Wikipedia/CC BY-SA 3.0
News This Week
Researchers have used liquid metals to develop new bacteria-destroying technology that could be the answer to the deadly problem of antibiotic resistance. The technology uses nano-sized particles of magnetic liquid metal to shred bacteria [...]
Lithium ion batteries often grow needle-like structures between electrodes that can short out the batteries and sometimes cause fires. Now, an international team of researchers has found a way to grow and observe these [...]
Researchers from ETH Zurich and the National University of Singapore have developed a new kind of bandage that helps blood to clot and doesn’t stick to the wound (Nature Communications, "Superhydrophobic hemostatic nanofiber [...]
Some quantum computers and networks store their information in an electron’s spin, which can be up or down – like the zeros or ones in a conventional computer. They can also be a combination [...]
The device uses lasers to accelerate electrons along an etched channel. In a full-scale particle accelerator, electrons fly along a kilometers-long path as microwaves bombard them, boosting the particles to near light speed. Such a [...]
Researchers found a way to create lasers smaller than red blood cells. These microlasers convert infrared light into light at higher frequencies. Made from nanoparticles, these are among the smallest, continuously emitting lasers of [...]
AS artificial intelligence technology continues to develop, like any new tech, questions begin to arise on its capabilities in warfare. Technology could ultimately be catastrophic for mankind. During an interview with Express.co.uk, he argued [...]
The University of Surrey has developed a robust multi-layer nano-barrier for ultra-lightweight and stable carbon fibre reinforced polymers (CFRPs) that could be used to build high precision instrument structures for future space missions. CFRP [...]
Scientists at the University of Otago in New Zealand say they have discovered how viruses that specifically kill bacteria can outwit bacteria by hiding from their defenses. These findings are important for the development [...]
Most synthetic materials, including those in battery electrodes, polymer membranes, and catalysts, degrade over time because they don't have internal repair mechanisms. If you could distribute autonomous microrobots within these materials, then you could [...]
For the first time, researchers have been able to record, frame-by-frame, how an electron interacts with certain atomic vibrations in a solid. The technique captures a process that commonly causes electrical resistance in materials [...]
Each Cyclops had a single eye because, legend has it, the mythical giants traded the other one with the god Hades in return for the ability to see into the future. But Hades tricked [...]
Over 200 molecules have been discovered in space, some (like Buckminsterfullerene) very complex with carbon atoms. Besides being intrinsically interesting, these molecules radiate away heat, helping giant clouds of interstellar material cool and contract [...]