Calcium ions are ubiquitous signalling molecules in all multicellular organisms, where they mediate diverse aspects of intracellular and extracellular communication over widely varying temporal and spatial scales.
Though techniques to map calcium-related activity at a high resolution by optical means are well established, there is currently no reliable method to measure calcium dynamics over large volumes in intact tissue. Here, we address this need by introducing a family of magnetic calcium-responsive nanoparticles (MaCaReNas) that can be detected by magnetic resonance imaging (MRI).
MaCaReNas respond within seconds to [Ca2+] changes in the 0.1–1.0 mM range, suitable for monitoring extracellular calcium signalling processes in the brain. We show that the probes permit the repeated detection of brain activation in response to diverse stimuli in vivo. MaCaReNas thus provide a tool for calcium-activity mapping in deep tissue and offer a precedent for the development of further nanoparticle-based sensors for dynamic molecular imaging with MRI.
Image Credit: From the researchers
News This Week
A red-hot anti-aging strategy quietly passed its first test earlier this year after 14 volunteers took drugs meant to kill off old, toxic cells in their bodies. The small study in people with [...]
Since the discovery of biological ion channels and their role in physiology, scientists have attempted to create man-made structures that mimic their biological counterparts. New research by Lawrence Livermore National Laboratory (LLNL) scientists and [...]
Sometimes it is too cold for us and then too warm again - annoying dressing-undressing of sweaters and co. Is therefore required. However, that may change: researchers have developed a sophisticated textile that can [...]
What is Global Health Care Equivalency (GHCE)? Looking ahead over the next 10-30 years, with the rapid emergence of, and synergies between, the disciplines of nanotechnology, nanomedicine, and AI, we can envisage a future [...]
Researchers in Singapore have built a refrigerator that’s just three atoms big. This quantum fridge won’t keep your drinks cold, but it’s cool proof of physics operating at the smallest scales. The work is [...]
Note: This videoblog is in German. It was produced by the Institute of Art & Art Theory of the University of Cologne. Humanity faces epochal challenges in the age of digitization. In particular, [...]