From the Annals of Neurology:
In less than 6 months, the severe acute respiratory syndrome‐coronavirus type 2 (SARS‐CoV‐2) has spread worldwide infecting nearly 6 million people and killing over 350,000. Initially thought to be restricted to the respiratory system, we now understand that coronavirus disease 2019 (COVID‐19) also involves multiple other organs including the central and peripheral nervous system.
The number of recognized neurologic manifestations of SARS‐CoV‐2 infection is rapidly accumulating. These may result from a variety of mechanisms including virus‐induced hyper‐inflammatory and hypercoagulable states, direct virus infection of the CNS, and post‐infectious immune mediated processes. Example of COVID‐19 CNS disease include encephalopathy, encephalitis, acute disseminated encephalomyelitis, meningitis, ischemic and hemorrhagic stroke, venous sinus thrombosis and endothelialitis. In the peripheral nervous system COVID‐19 is associated with dysfunction of smell and taste, muscle injury, the Guillain‐Barre syndrome and its variants.
Due to its worldwide distribution and multifactorial pathogenic mechanisms, COVID‐19 poses a global threat to the entire nervous system. While our understanding of SARS‐CoV‐2 neuropathogenesis is still incomplete and our knowledge is evolving rapidly, we hope that this review will provide a useful framework and help neurologists in understanding the many neurologic facets of COVID‐19.
Image Credit: Annals of Neurology
News This Week
Warning of serious brain disorders in people with mild coronavirus symptoms
Doctors may be missing signs of serious and potentially fatal brain disorders triggered by coronavirus, as they emerge in mildly affected or recovering patients, scientists have warned. Neurologists are on Wednesday publishing details of [...]
Nanoparticles Offer a Promising Way for Treating Cancer, Liver Disorders
University of Wisconsin-Madison researchers have developed a safer and more efficient way to deliver a promising new method for treating cancer and liver disorders and for vaccination -- including a COVID-19 vaccine from Moderna [...]
Covid-19 vaccines may be stifled by pre-existing antibodies
Despite its advantages over other vaccine technologies for Covid-19, adenovirus vector vaccines are likely to be tripped up by pre-existing antibodies to the vectors used and the need for a second injection to boost [...]
This coronavirus mutation has taken over the world. Scientists are trying to understand why.
When the first coronavirus cases in Chicago appeared in January, they bore the same genetic signatures as a germ that emerged in China weeks before. But as Egon Ozer, an infectious-disease specialist at the Northwestern University [...]
Online Special Edition “NanoScientific Symposium on Nano Applications”
Park Systems presents “NanoScientific Symposium on Nano Applications for a Changing World” sponsored by Physics World and Nanotechnology World Association. Park Systems launched this online event for researchers and scientists in nanoscience and nanotechnology [...]
Medical nanotechnology research for COVID-19
Notwithstanding the wishful thinking of certain irresponsible and incompetent public figures, the only options to control and deal with the spread of the Severe Acute Respiratory Syndrome Virus 2 (SARS-CoV-2) are fast, cheap, reliable, [...]
COVID ‐19: A new paper on the global threat to the nervous system
From the Annals of Neurology: In less than 6 months, the severe acute respiratory syndrome‐coronavirus type 2 (SARS‐CoV‐2) has spread worldwide infecting nearly 6 million people and killing over 350,000. Initially thought to be restricted [...]
Steroid found to help prevent deaths of sickest coronavirus patients
A cheap steroid has become the first life-saving treatment in the Covid-19 pandemic, described by scientists as a major breakthrough and raising hopes for the survival of thousands of the most seriously ill. Dexamethasone [...]
Imperial to begin first human trials of new COVID-19 vaccine
Clinical researchers are this week set to begin human trials of a new coronavirus vaccine developed by researchers at Imperial College London. The study will be the first time the vaccine has been trialled in humans [...]
Study: Dominant form of virus ‘10 times’ more infectious than original strain
A form of the novel coronavirus which has become the dominant type in much of the world may have done so thanks to a mutation that allows it to better latch onto human hosts’ [...]
Widely available indigestion drug may curb COVID-19 symptoms in mild to moderate disease
A widely available and inexpensive drug that is used to ease the symptoms of indigestion may prove a worthy contender for treating COVID-19 infection in those whose disease doesn’t require admission to hospital, suggest [...]
Ohio State researchers testing breathalyzer to detect COVID-19
One of the most common COVID-19 tests involves a long swab pressed deep into the nasal cavities – and while the test can be administered quickly, it has been described as unpleasant and uncomfortable. [...]
Coronavirus research updates: Positive coronavirus test is no guarantee of infectiousness
Nature wades through the literature on the new coronavirus — and summarizes key papers as they appear: 1 June — Positive coronavirus test is no guarantee of infectiousness People with COVID-19 are unlikely to [...]
Coronavirus May Be a Blood Vessel Disease, Which Explains Everything
In April, blood clots emerged as one of the many mysterious symptoms attributed to Covid-19, a disease that had initially been thought to largely affect the lungs in the form of pneumonia. Quickly after came [...]
Researchers develop experimental rapid COVID-19 test using nanoparticle technique
Scientists from the University of Maryland School of Medicine (UMSOM) developed an experimental diagnostic test for COVID-19 that can visually detect the presence of the virus in 10 minutes. It uses a simple assay [...]
Researchers flag similarities between COVID-19 deaths and severe rheumatic illnesses
Rheumatologists at the University of Alberta are flagging similarities between the deaths of some COVID-19 patients and those with rheumatic illnesses, and are testing proven rheumatic treatments to see whether they help against [...]
