Ultrasmall targeted nanoparticles with engineered antibody fragments as an anti-cancer weapon

Antibody-based imaging of a particularly aggressive form of breast cancer is undergoing clinical trials worldwide, but the path from trial to application is being hampered by a major obstacle: safety.

Concerns stem from inefficient tumor targeting, which can result in accumulation in the bone marrow, liver and kidneys of the radioactive material necessary for the imaging. Recent efforts have focused on nanoscale delivery vehicles with immune components, but these vehicles are often still too large (20 nanometers or larger) for renal clearance after imaging.

Ulrich Wiesner, the Spencer T. Olin Professor of Engineering in materials science and engineering, in collaboration with Dr. Michelle Bradbury of Memorial Sloan Kettering Cancer Center (MSKCC) and Weill Cornell Medicine, has proposed a novel approach using ultrasmall silica nanoparticles – better known as “Cornell dots” (or C dots) – invented in his lab more than a dozen years ago.

Their team – including researchers at pharmaceutical company MedImmune – have equipped the C dots with antibody fragments. Because the resulting conjugates are smaller than 8 nanometers, these C dots allow for renal clearance while achieving the specificity needed for efficient tumor targeting.
They report their discovery in Nature Communications (“Ultrasmall Targeted Nanoparticles with Engineered Antibody Fragments for Imaging Detection of HER2-Overexpressing Breast Cancer“). Feng Chen, senior research scientist at MSKCC, and Kai Ma, postdoctoral researcher in the Wiesner lab, are co-lead authors.

Read more at nanowerk.com

Image Credit:    Wiesner lab, Cornell University

News This Week

Five ways how natural nanotechnology is stimulating human innovation

From CIO Applications: Although nanotechnology is depicted as genuinely recent human development, nature is in reality loaded with nanoscopic designs. They support the fundamental elements of an assortment of living things, from microorganisms to [...]

NASA certifies Falcon 9 for highest priority science missions

NASA has certified SpaceX’s Falcon 9 to launch the agency’s most important science missions, giving the agency new options that could result in lower costs. SpaceX said that the NASA Launch Services Program (LSP) [...]

NASA to support initial studies of privately funded Enceladus mission

NASA signed an agreement in September with a foundation to support initial studies of a privately funded mission to a potentially habitable moon of Saturn. The unfunded Space Act Agreement between NASA and the [...]

First-ever prostate cancer treatment uses gold nanoparticles to destroy tumorous cells

A small clinical trial using gold nanoparticles that act as tumor-seeking missiles on a mission to remove prostate cancer has begun at The University of Texas Health Science Center at Houston (UTHealth). It [...]

A new path through the looking-glass

Exploring the mystery of the molecular handedness in nature, scientists have proposed a new experimental scheme to create custom-made mirror molecules for analysis. The technique can make ordinary molecules spin so fast that they [...]

First-ever prostate cancer treatment uses gold nanoparticles to destroy tumorous cells

A small clinical trial using gold nanoparticles that act as tumor-seeking missiles on a mission to remove prostate cancer has begun at The University of Texas Health Science Center at Houston (UTHealth). It is [...]

Nanomedical Device and Systems Design: Challenges, Possibilities, Visions now available to rent on Kindle

To accommodate students who wish to read the book at an affordable cost, Nanomedical Device and Systems Design: Challenges, Possibilities, Visions by Frank Boehm (CEO NanoApps Medical Inc.) is available to rent on Kindle. This book benefits [...]

New nano-immunotherapy promotes long-term acceptance of transplanted organs

Researchers at the Mount Sinai School of Medicine have developed a new nanotechnology-based immunotherapy that promotes long-term transplant acceptance in an animal model. The development, which is described in the journal Immunity, could transform [...]

Physicists name and codify new field in nanotechnology: ‘Electron Quantum Metamaterials’

“It’s a bit like driving past a vineyard and looking out the window at the vineyard rows. Every now and then, you see no rows because you’re looking directly along a row,” said Nathaniel [...]

Tying the knot: New DNA nanostructures

Knots are indispensable tools for such human activities as sailing, fishing and rock climbing, (not to mention, tying shoes). But tying a knot in a lacelike strand of DNA, measuring just billionths of a [...]

Nanoparticle Therapy for Prostate Cancer Treatments

The use of nanoparticles and other nanoscale materials has been gathering a lot of significant interest in recent years and has even adapted into its own interdisciplinary field of science known as nanomedicine. Whilst [...]

Frank Boehm contributes to ‘Immune Aspects of Biopharmaceuticals and Nanomedicines’ – CRC Press

Immune Aspects of Biopharmaceuticals and Nanomedicines 1st Edition Raj Bawa, Janos Szebeni, Thomas J Webster, Gerald F. Audette The enormous advances in the immunology of biotherapeutics and nanomedicines in the past two decades have [...]

Other published works by Frank Boehm, NA Founder

Immune Aspects of Biopharmaceuticals and Nanomedicines Available from CRC Press 1st Edition Raj Bawa, Janos Szebeni, Thomas J Webster, Gerald F. Audette The enormous advances in the immunology of biotherapeutics and nanomedicines in the [...]

Nanorobots that can drill through the eye

Researchers of the “Micro, Nano and Molecular Systems” Lab at the Max Planck Institute for Intelligent Systems in Stuttgart, together with an international team of scientists, developed propeller-shaped nanorobots that, for the first time, [...]

International Conference on Emerging Advanced Nanomaterials (ICEAN) 2018

Nanotechnology experts from around the world, who use innovation in materials science to create advanced technologies and solutions for the environment, energy, and health sectors, will congregate in Newcastle Australia for the third International [...]

Nanowire-based light detectors work like gecko ears

Geckos and many other animals have heads that are too small to triangulate the location of noises the way we do, with widely spaced ears. Instead, they have a tiny tunnel through their heads [...]

2018-10-15T03:51:24+00:00

Leave A Comment