Clinicians have often pondered if cancer cells could be selectively targeted, and how payloads ranging from fluorescent dyes to oncology drugs could be accurately delivered to these cells, and then safely cleared through the kidneys. Now, researchers at Memorial Sloan Kettering Cancer Center, and Nanotechnology in the College of Engineering at Cornell University have found the answer in the form of a new class of ultra-small nanoparticles that are showing significant potential for cancer diagnosis and treatment, and positive results in pre-clinical and clinical trials.
Researchers are finding that the use of new ultra-small nanoparticles called C-dots allows improved visualization in Positron Emission Tomography (PET) scans for diagnosis and real-time image-guided intraoperative mapping of nodal metastases to aid in precise surgical excision, currently in Phase II human clinical trials.
These ultra-small particles can also serve as a precision therapeutic solution, targeting and penetrating cancer cells to deliver a range of cancer-killing drugs, with the promise of unused particles and the drugs they carry safely leaving the body through the renal system.
The architecture of the C-dot is an ultra-small silica nanoparticle with a diameter of less than 10 nanometers, first innovated at Cornell University by Ulrich Wiesner, the Spencer T. Olin Professor of Engineering. Silica, also known as silicon dioxide (SiO2), is a widely existing inorganic composition which can be found in many places, e.g. plants, cosmetics, medicine and food such as bread crust.
Multiple near infrared (near-IR) fluorescent dye molecules can be covalently encapsulated inside the silica particle, and the fluorescence brightness of these molecules is further enhanced by the rigid surrounding silica matrix. As a result, the overall fluorescence brightness of C-dots can be one order of magnitude higher than that of dyes alone, delivering new capabilities to surgeons. Meanwhile, the surface of C-dots is covalently covered with polymer chains to increase bio-compatibility. Due to the high versatility of the synthesis chemistry of C-dots, different functional ligands can be selectively attached to the end of some of the polymer chains on the C-dot surface to endow the particles with a variety of functionalities for different applications, including, but not limited to cancer targeting, radio-isotopes chelating, and small molecule drug delivery.
Importantly, the ultra-small hydrodynamic size of C-dots enable them to be efficiently cleared from the body through the renal system.
Image Credit: Elucida Oncology
News This Week
LAS CRUCES, N.M. — Members of an independent NASA safety panel said they were worried that the Oct. 11 Soyuz launch failure could make safety concerns with the agency's commercial crew program even worse. [...]
Canadian astronaut Col. Chris Hadfield (Ret.) on Friday said that human travel to space will happen sooner than we think, adding that the first destination will likely be a return trip to the moon. [...]
Antibody-based imaging of a particularly aggressive form of breast cancer is undergoing clinical trials worldwide, but the path from trial to application is being hampered by a major obstacle: safety. Concerns stem from inefficient [...]
Following the discovery of graphene in 2003, there has been considerable interest in other types of 2D materials. However, splitting a bulk crystal material into 2D flakes for use in electronics has proven hard [...]
The digital economy is set to unlock tremendous economic value for countries over time. But a common setback for the use of various new technologies is their vulnerability to hackers. That's because companies and [...]
Nanomedical Device and Systems Design: Challenges, Possibilities, Visions now available to rent on Kindle
To accommodate students who wish to read the book at an affordable cost, Nanomedical Device and Systems Design: Challenges, Possibilities, Visions by Frank Boehm (CEO NanoApps Medical Inc.) is available to rent on Kindle. This book benefits [...]
The last five years has seen a surge of attacks on the healthcare industry, with the largest breaches impacting as many as 80 million people. In July this year, it was revealed that 150,000 [...]
The Nanoaugmented Materials Industry Summit (NAUM) 2018 in Shanghai on October 31 will gather the world’s leading companies who use and apply graphene nanotubes to share exciting results. This year the event is opening [...]
Any truck operator knows that hydraulics do the heavy lifting. Water does the work because it's nearly incompressible at normal scales. But things behave strangely in nanotechnology, the control of materials at the scale [...]
Myeloperoxidase - an enzyme naturally found in our lungs - can biodegrade pristine graphene, according to the latest discovery of Graphene Flagship partners in CNRS, University of Strasbourg (France), Karolinska Institute (Sweden) and University [...]
In today’s hospitals and healthcare clinics, a new doctor’s new assistant is now often on the job — in the form of artificial intelligence. Whether it’s analyzing medical images or guiding robots that assist [...]
Healthcare cybersecurity will be one of the top 10 challenges, issues, and/or opportunities facing healthcare executives next year, according to a new poll by the Healthcare Executive Group (HCEG). Healthcare cybersecurity covers such issues [...]
A research team has developed a nano-platform technology that works in combination with existing chemotherapeutic drugs that may reverse drug-resistance in renal cell carcinoma. Drug resistance to chemotherapy is a significant clinical and financial [...]