Nanorobots For Senescent Cell Clearance

One extremely promising and emerging field of research is nano-biotechnology. Nano-biotechnology could potentially be an extremely powerful tool in our quest for a longer, healthier life.

Senescent cells are known to be essential in multiple aging processes. Getting rid of these problem cells is, therefore, something we could do to potentially increase our healthy lifespan, and nanoscale robots may help us do just this.

Detecting senescent cells

Senescent cells have different levels of gene expression and mitochondrial function, different epigenetics, and a different secretome profile. Therefore, they secrete specific molecules in specific quantities [1], and this is very important for detecting and targeting them.

The detection and targeting of these senescent cells is somewhat difficult and currently not very precise [1]. This is due to there being different types of senescent cells, including a non-chronic (non-damaging) type as well as changes in senescent cells that also occur in healthy cells. Currently, the most common way to detect senescent cells is by measuring SA-beta-gal activity. SA-beta-gal is an isoform of the beta-galactosidase enzyme (an enzyme normally responsible for the breakdown of sugars known as beta-galactosides). This isoform is widely expressed by senescent cells and is optimally active at pH 6.0, thus making it possible to detect these cells by assaying them for the presence of SA-beta-gal. However, this has major limitations, as SA-beta-gal can be expressed in non-senescent cells under certain conditions and is absent in some senescent cells [2]. Other markers for senescence, such as lipofuscin (pigment granules), have been used, but they also have limitations, such as not being exclusive to senescent cells. Regardless of the limitations, SA-beta-gal is a good marker for senescence until better markers are discovered. Once detected, we have to get to these cells, bind to them specifically, and kill them.

Read more at leafscience.org

Image Credit:   Shutterstock

News This Week

Frank Boehm contributes to ‘Immune Aspects of Biopharmaceuticals and Nanomedicines’ – CRC Press

Immune Aspects of Biopharmaceuticals and Nanomedicines 1st Edition Raj Bawa, Janos Szebeni, Thomas J Webster, Gerald F. Audette The enormous advances in the immunology of biotherapeutics and nanomedicines in the past two decades have [...]

Safety Panel Fears Soyuz Failure Could Exacerbate Commercial Crew Safety Concerns

LAS CRUCES, N.M. — Members of an independent NASA safety panel said they were worried that the Oct. 11 Soyuz launch failure could make safety concerns with the agency's commercial crew program even worse. [...]

Canadian astronaut says human space travel will advance ‘sooner than you think’

Canadian astronaut Col. Chris Hadfield (Ret.) on Friday said that human travel to space will happen sooner than we think, adding that the first destination will likely be a return trip to the moon. [...]

Ultrasmall targeted nanoparticles with engineered antibody fragments as an anti-cancer weapon

Antibody-based imaging of a particularly aggressive form of breast cancer is undergoing clinical trials worldwide, but the path from trial to application is being hampered by a major obstacle: safety. Concerns stem from inefficient [...]

New Method Allows Harvesting of 2D Materials in Minutes

Following the discovery of graphene in 2003, there has been considerable interest in other types of 2D materials. However, splitting a bulk crystal material into 2D flakes for use in electronics has proven hard [...]

Cybersecurity isn’t being taken seriously enough: MIT professor

The digital economy is set to unlock tremendous economic value for countries over time. But a common setback for the use of various new technologies is their vulnerability to hackers. That's because companies and [...]

Other published works by Frank Boehm

Frank Boehm (NanoApps Medical CEO) and Angelika Domschke contributed the chapter : “Application of a Conceptual Nanomedical Platform to Facilitate the Mapping of the Human Brain: Survey of Cognitive Functions and Implications”. The book [...]

Nanomedical Device and Systems Design: Challenges, Possibilities, Visions now available to rent on Kindle

To accommodate students who wish to read the book at an affordable cost, Nanomedical Device and Systems Design: Challenges, Possibilities, Visions by Frank Boehm (CEO NanoApps Medical Inc.) is available to rent on Kindle. This book benefits [...]

Why Cyber-Criminals Are Attacking Healthcare — And How To Stop Them

The last five years has seen a surge of attacks on the healthcare industry, with the largest breaches impacting as many as 80 million people. In July this year, it was revealed that 150,000 [...]

A new era in the quest for dark matter

Since the 1970s, astronomers and physicists have been gathering evidence for the presence in the universe of dark matter: a mysterious substance that manifests itself through its gravitational pull. However, despite much effort, none [...]

The Largest Event on Graphene Nanotubes is Open to the Public for the First Time

The Nanoaugmented Materials Industry Summit (NAUM) 2018 in Shanghai on October 31 will gather the world’s leading companies who use and apply graphene nanotubes to share exciting results. This year the event is opening [...]

Simulations show new phenomenon with nanopore DNA sequencing

Any truck operator knows that hydraulics do the heavy lifting. Water does the work because it's nearly incompressible at normal scales. But things behave strangely in nanotechnology, the control of materials at the scale [...]

A human enzyme can biodegrade graphene

Myeloperoxidase - an enzyme naturally found in our lungs - can biodegrade pristine graphene, according to the latest discovery of Graphene Flagship partners in CNRS, University of Strasbourg (France), Karolinska Institute (Sweden) and University [...]

A new weapon in the battle against cancer – Artificial Intelligence

In today’s hospitals and healthcare clinics, a new doctor’s new assistant is now often on the job — in the form of artificial intelligence. Whether it’s analyzing medical images or guiding robots that assist [...]

Healthcare Cybersecurity Is a Top 2019 Executive Challenge

Healthcare cybersecurity will be one of the top 10 challenges, issues, and/or opportunities facing healthcare executives next year, according to a new poll by the Healthcare Executive Group (HCEG). Healthcare cybersecurity covers such issues [...]

Nanotherapy offers hope in treating drug-resistant renal cell carcinoma

A research team has developed a nano-platform technology that works in combination with existing chemotherapeutic drugs that may reverse drug-resistance in renal cell carcinoma. Drug resistance to chemotherapy is a significant clinical and financial [...]

2018-08-27T06:00:04+00:00

Leave A Comment