One extremely promising and emerging field of research is nano-biotechnology. Nano-biotechnology could potentially be an extremely powerful tool in our quest for a longer, healthier life.
Senescent cells are known to be essential in multiple aging processes. Getting rid of these problem cells is, therefore, something we could do to potentially increase our healthy lifespan, and nanoscale robots may help us do just this.
Detecting senescent cells
Senescent cells have different levels of gene expression and mitochondrial function, different epigenetics, and a different secretome profile. Therefore, they secrete specific molecules in specific quantities , and this is very important for detecting and targeting them.
The detection and targeting of these senescent cells is somewhat difficult and currently not very precise . This is due to there being different types of senescent cells, including a non-chronic (non-damaging) type as well as changes in senescent cells that also occur in healthy cells. Currently, the most common way to detect senescent cells is by measuring SA-beta-gal activity. SA-beta-gal is an isoform of the beta-galactosidase enzyme (an enzyme normally responsible for the breakdown of sugars known as beta-galactosides). This isoform is widely expressed by senescent cells and is optimally active at pH 6.0, thus making it possible to detect these cells by assaying them for the presence of SA-beta-gal. However, this has major limitations, as SA-beta-gal can be expressed in non-senescent cells under certain conditions and is absent in some senescent cells . Other markers for senescence, such as lipofuscin (pigment granules), have been used, but they also have limitations, such as not being exclusive to senescent cells. Regardless of the limitations, SA-beta-gal is a good marker for senescence until better markers are discovered. Once detected, we have to get to these cells, bind to them specifically, and kill them.
Image Credit: Shutterstock
News This Week
As they grow, solid tumors surround themselves with a thick, hard-to-penetrate wall of molecular defenses. Getting drugs past that barricade is notoriously difficult. Now, scientists at UT Southwestern have developed nanoparticles that can break [...]
In an article recently published in the journal Talanta, researchers demonstrated a new approach to enable the specific detection of biomarkers in human tear by employing an aptamer-based graphene affinity nanosensor. The ability to detect [...]
Selenium (Se) is an essential element found in aquatic feeds that promotes the proper development, wellbeing, and fitness of marine animals. Selenium can be transformed into nanomaterials that are more easily accessible, absorbed, and consumed by [...]
In an article recently published in the journal Nanotechnology, researchers employed a single particle imaging method for fluorescence excitation with moderate intensity to achieve spatial resolution. Here, the semiconductor nanocrystals were accessed, whose emission lifetimes [...]
Grinding is an essential manufacturing process, yet the heat due to friction associated with the process causes damage to the part being processed. Lubrication is used to reduce friction; however, traditional petroleum-based lubricants can [...]
A team of researchers from HSE University, Skoltech, MPGU, and MISIS have developed a nanophotonic-microfluidic sensor whose potential applications include cancer detection, monitoring and treatment response assessment. Today, the device can identify gases and [...]
Researchers have made a scientific breakthrough with the development of ‘nanomachines’ that can kill cancerous cells. The research team headed by Dr Youngdo Jeong from the Center for Advanced Biomolecular Recognition at the Korea Institute of Science and Technology (KIST) has engineered [...]
A novel freeze-dissolving approach has been devised that offers greater efficiency and sustainability compared to the classic freeze-drying process to make superfine powder or nanoparticles. In the research published in the journal ACS Sustainable Chemistry & Engineering, sphere-shaped [...]
Participants wanted for study on the regulation of what future AI-driven nanomedicines should look like
Would you like to help in some research on the regulation of what future AI-driven nanomedicines should look like? If so, researchers at the University of Bristol are looking for volunteers to discuss ethical [...]
In an article recently published in the journal Applied Surface Science, the researchers synthesized green fluorescent carbon dots (G-CDs) from 3,5-diaminobenzoic acid and citric acid. The as-prepared G-CDs were used to target the nucleolus and [...]
Doxorubicin (DOX) is a powerful anti-cancer medication, and efforts have been made to design nanostructures for delivering it to cancerous cells. The nanostructures increase the cytotoxic effects of DOX on cancerous cells, while reducing the negative effects [...]
A team of Brown University researchers has developed a new responsive material that is able to release encapsulated cargo only when pathogenic bacteria are present. The material could be used to make wound dressings [...]
Novel three-drug regimen used to manage life-threatening developments. In April 2021, a 42-year-old man reached out to Brian Hill, MD, PhD, for a second opinion after being diagnosed with hairy cell leukemia following a bone [...]
When the virus hunters landed in the remote African village of Yambuku in 1976, the nuns warned them to stay back. The sisters had cordoned off the area where they were caring for people [...]