Like our eyes, microscopes are limited in what they can see because of their resolution, or their ability to see detail. The detail, or information, from the object is there, but some of it gets lost as the light reflecting off of the object moves through the air.
“The whole premise of this is built on one single fact—the way light interacts with any matter is linear,” said Kamilov, assistant professor of electrical & systems engineering and computer science & engineering. “But the reality is that the interaction is actually not linear.”
For example, if you shine a flashlight through your hand, you can’t see the source of the light because it’s bending, and that is nonlinearity. With a single cell, the bending is so light that it is nearly transparent, which is linear.
When light interacts with a cell or an object, the light going out of the cell loses the information it gathers from that interaction. But because of that interaction, there are fluctuations in the vicinity of that cell that work with such matter and get retransformed and remitted. Those fluctuations are encoded into the nonlinearity of the interaction, but today’s microscopes are unable see this, Kamilov said.
“We want to take into account this nonlinear interaction of light, objects and premises, and if we do it correctly, we can extract that information, which normally disappears in a current microscope and is treated as ‘noise,'” Kamilov said. “We want to decode the information from the noise and add it back into the resolution, and that should give us features that are smaller than the resolution limit.”
Kamilov said there are two types of noise: imperfections and mathematical noise that is the result of science’s current limitations. It is the mathematical noise that he wants to capture.
Image Credit: Washington University in St. Louis
News This Week
The University of Oxford, in collaboration with AstraZeneca plc, today announces interim trial data from its Phase III trials that show its candidate vaccine, ChAdOx1 nCoV-2019, is effective at preventing COVID-19 (SARS-CoV-2) and offers a [...]
A genetic modification in the ‘coat’ of a brain infection-causing virus may allow it to escape antibodies, according to Penn State College of Medicine researchers. They say testing people for this and other viral mutations [...]
Current chemotherapy regimens slow cancer progression and save lives, but these powerful drugs affect both healthy and cancerous cells. Now, researchers reporting in ACS' Nano Letters have designed DNA-based nanogels that only break down and [...]
The new technology behind Pfizer's and Moderna's coronavirus vaccines could be used to prevent everything from heart disease to cancer, experts say. The breakthrough vaccine 'platform' they use transforms the body into a virus-zapping vaccine [...]
Current state-of-the-art techniques have clear limitations when it comes to imaging the smallest nanoparticles, making it difficult for researchers to study viruses and other structures at the molecular level. Scientists from the University of Houston [...]
Virtual patients, vaccines, medicine-making biomachines and microneedles are examples of tech innovation that is meeting the moment to address the global health crisis. Health has been a strong focus for this year’s top 10 [...]
A Vancouver company is central to the news Monday morning that Pfizer is close to developing an effective vaccine against the coronavirus. Pfizer said Monday that an early peek at the data on its [...]