Synthetic protocells can be made to move toward and away from chemical signals, an important step for the development of new drug-delivery systems that could target specific locations in the body. By coating the surface of the protocells with enzymes–proteins that catalyze chemical reactions–a team of researchers at Penn State was able to control the direction of the protocell’s movement in a chemical gradient in a microfluidic device. | |
A paper describing the research appears in the journal Nature Nanotechnology (“Positive and negative chemotaxis of enzyme-coated liposome motors”). | |
“The futuristic vision is to have drugs delivered by tiny ‘bots’ that can transport the drug to the specific location where it is needed,” said Ayusman Sen, the Verne M. Willaman Professor of Chemistry at Penn State and the leader of the research team. “Currently, if you take an antibiotic for an infection in your leg, it diffuses throughout your entire body. So, you have to take a higher dose in order to get enough of the antibiotic to your leg where it is needed. If we can control the directional movement of a drug-delivery system, we not only reduce the amount of the drug required but also can increase its speed of delivery.” |
Image Credit: Ambika Somasundar, Penn State
News This Week
Global Warming and Plastic Pollution Are Inextricably Trapped in a “Vicious Circle”
Typically viewed as unrelated problems, global warming and plastic pollution are instead inextricably trapped in a “vicious circle” where one feeds the other, researchers in Sweden report in Nature Communications. The mutually-reinforcing relationship escalates global [...]
Primordial Fuel: Uncovering Hydrogen’s Role at the Origin of Life
Hydrogen gas, dubbed the energy of the future, has been providing energy since 4 billion years ago. A recent study reveals how hydrogen gas, often touted as the energy source of tomorrow, provided energy [...]
COVID-19 Had a Much Greater Impact on Life Expectancy Than Previously Thought
A recent study published in The Lancet never-before-seen unprecedented details on the exceptionally high death rates due to the COVID-19 pandemic both within nations and internationally. Regions including Mexico City, Peru, and Bolivia experienced some of the most [...]
Molecular Majesty: This Is How the Body’s Building Blocks Are Made
Human cells contain ribosomes, a complex machine that produces proteins for the rest of the body. Now the researchers have come closer to understanding how the ribosome works. “It is amazing that we can [...]
U.S. issue warning about return of potentially deadly virus
The American South has been under constant duress from extreme weather events spurred by rising global temperatures, but the region could face a different kind of threat that it hasn't experienced in over a century: yellow fever. [...]
Climate Change Ignites Global Infectious Disease Alarm
Experts highlight the connection between climate change and infectious diseases, urging medical professionals to prepare for new disease patterns and advocate for climate action. A team of infectious diseases experts called for more awareness [...]
How Lignin Nanoparticles Enhance UV Protection in Sunscreen Formulas
The innovative realm of cosmetic science has recently spotlighted lignin nanoparticles (LNPs) for their exceptional potential in fortifying sun protection measures within skincare products. These nanoparticles are celebrated for their superior ability to block [...]
mRNA lipid nanoparticles for next-generation oral cancer tumor suppressor therapy
A study aiming to develop a lipid nanoparticles (LNP) platform for treating oral squamous cell carcinoma (OSCC) utilizing p53 mRNA was presented at the 102nd General Session of the IADR, which was held in conjunction [...]
Scientists have literally cut HIV out of cells
HIV has been completely eliminated from cells in a laboratory, raising hopes of a future cure. Researchers completed the revolutionary task by using a gene-editing tool known as Crispr-Cas, which won the Nobel Prize in 2020, [...]
Common Medication Could Save Half a Million Lives Each Year – So Why Isn’t It?
A recent study conducted by scientists at the University of Southern California sheds light on the reasons why children are not receiving an affordable and effective diarrhea treatment. Medical professionals in developing nations are [...]
X Marks the Spot: AI’s Treasure Maps Lead to Early Disease Detection
Medical diagnostics expert, doctor’s assistant, and cartographer are all fair titles for an artificial intelligence model developed by researchers at the Beckman Institute for Advanced Science and Technology. Their new model accurately identifies tumors [...]
Scientists Discover Method To Identify Alzheimer’s Disease Before It Progresses to Dementia
Researchers at Aarhus University have discovered a method to identify Alzheimer’s disease before it progresses to dementia, potentially opening up new avenues for treatment. A groundbreaking study could pave the way for early detection [...]
Startling Discovery: COVID-19 Virus Can Stay in the Body More Than a Year After Infection
The COVID-19 virus can persist in the blood and tissue of patients for more than a year after the acute phase of the illness has ended, according to new research from UC San Francisco that offers potential [...]
New bioengineered protein design shows promise in fighting COVID-19
In the wake of the COVID-19 pandemic, scientists have been racing to develop effective treatments and preventatives against the virus. A recent scientific breakthrough has emerged from the work of researchers aiming to combat [...]
Sugar-coated gold nanoparticles can quickly eliminate bacterial infections, no antibiotics required
If left to their own devices, bacteria on our teeth or wounded skin can encase themselves in a slimy scaffolding, turning into what is called biofilm. These bacteria wreak havoc on our tissue and, [...]
Liquid Lightning: Nanotechnology Unlocks New Energy
EPFL researchers have discovered that nanoscale devices harnessing the hydroelectric effect can harvest electricity from the evaporation of fluids with higher ion concentrations than purified water, revealing a vast untapped energy potential. Evaporation is a natural [...]