Faculty members at the UM School of Medicine have created a cutting-edge tool that enables the early identification and assessment of risks in vulnerable patients.
Heart disease, being the leading cause of death globally, has prompted scientists to investigate the compounded effects of multiple risk factors such as hypertension, obesity, and high cholesterol on an individual's likelihood of suffering from a heart attack or stroke. Utilizing advanced modeling techniques, researchers from the University of Maryland School of Medicine (UMSOM) have created a novel tool capable of predicting heart disease risk in individuals aged over 40 based on their lifelong exposure to these risk factors.
Their groundbreaking research, recently published in the Journal of the American College of Cardiology, leveraged data from the Coronary Artery Risk Development in Young Adults (CARDIA) study. CARDIA, which tracked nearly 5,000 healthy young adults from four cities in the US for three decades, provided the researchers with data that allowed them to calculate the combined effects of individual risk factors like hypertension, diabetes, and high cholesterol. Moreover, they were able to measure the additive impact of multiple risk factors leading to cardiovascular disease.
"These data make clear the importance of instituting risk-factor reduction strategies as early in life as is feasible to reduce time-related cumulative exposure to harmful risks," said study lead author Michael J. Domanski, MD, Professor of Medicine, at UMSOM. "These results suggest that a self-declared Black racial status is a marker of underlying and unexplained differences in risk-factor impact."
The results of this study could help guide physicians in developing personalized prevention strategies for individual patients. Public health policymakers also could use the new risk calculation tool to assess the likely impact of proposed heart disease prevention programs, while researchers could use it to help design clinical trials to test heart disease prevention strategies.
"By examining the long-term impact of multiple risk factors on cardiovascular disease, our study highlights the importance of cumulative exposure in determining an individual's risk," said Xin Tian, Ph.D., Adjunct Professor at UMSOM, and a biostatistician at the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH). "Our findings underscore the need for personalized prevention strategies that address both the time course and severity of these risk factors. As scientists, our duty is to use this knowledge to inform the development of effective prevention and intervention strategies that can reduce the burden of cardiovascular disease on individuals and society as a whole."
The R Shiny app, developed in this study, is a tool that allows medical providers to insert cardiovascular risks, patient history, and patient race to determine individual risks and how best to address them. Electronic medical records are now widely available, making the development of tools such as the R Shiny app possible. R Shiny can be used to estimate cardiovascular risks after age 40 based on the severity of risk factors earlier in adulthood. The app is hosted on NHLBI's website.
"Our study demonstrates the power of innovative statistical data-science approaches in enabling biomedical researchers to gain deeper insights into complex health issues, such as cardiovascular disease. We were able to develop risk prediction models that provide a more accurate and personalized assessment of an individual's risk," said Colin Wu, Ph.D., Adjunct Professor of Medicine at UMSOM and a mathematical statistician at NHLBI, part of NIH.
During the two-decade follow-up period after age 40, the researchers found that 316 people in the study experienced their first cardiovascular event, including heart disease, strokes, and congestive heart failure.
"This new tool could be used by cardiologists to convince patients to take the necessary steps to lower their risk of heart attack or stroke by quantifying how much their risk would improve if they better managed, for example, their cholesterol and hypertension," said Mark Gladwin, MD, Dean, University of Maryland School of Medicine, Vice President for Medical Affairs, University of Maryland, Baltimore, and the John Z. and Akiko K. Bowers Distinguished Professor. "That could have a significant impact, particularly in vulnerable populations who have not been aggressively treated for cardiovascular risks in the past due to long-standing health inequities."
News
UCLA Scientists Uncover a “Hidden Weakness” in Some of the World’s Deadliest Cancers
A new study has uncovered an unexpected vulnerability in some of the deadliest cancers. Researchers at UCLA have identified a previously hidden weakness in some of the most aggressive cancers, pointing to a possible new way [...]
AI-designed universal coronavirus vaccine clears first human trial
Key Takeaways Super-Antigen Technology: Uses AI and machine learning to analyze viral genomes, creating a single vaccine that targets essential features across entire virus families, including coronaviruses and Ebola. Human Trials & Safety: Phase [...]
Researchers Discover a Hidden Vitamin D Problem That Persists Year-Round
A new study suggests that some groups may not experience the expected seasonal boost in vitamin D levels, even during the sunniest months of the year. Many people assume that spending more time outdoors [...]
Researchers Solve the Mystery Behind a Billion-Dollar Dental Implant Disease
Researchers have uncovered why a common and costly dental implant infection often resists antibiotics. Dental implants have helped tens of millions of people regain a full set of stable, functional teeth, something traditional dentures [...]
Nanoparticles inspired by lung fluid improve therapies targeting respiratory system
The CIC biomaGUNE Center for Cooperative Research in Biomaterials has developed pulmonary surfactant nanoparticles (the blend of lipids and proteins that line the alveoli and enables breathing), which are encapsulated [...]
Scientists Finally Uncover How a “Forever Chemical” Causes Birth Defects
PFDA, a PFAS “forever chemical,” can cause craniofacial birth defects by disrupting retinoic acid regulation during fetal development, revealing the first clear molecular mechanism behind the link. Researchers have long linked perfluoroalkyl and polyfluoroalkyl substances (PFAS), [...]
Scientists Have Discovered These Deadly Parasites Are Secretly Swapping DNA
Leishmania parasites appear to evolve through widespread genetic exchange, reshaping assumptions about how they adapt and spread. A parasite long thought to spread mostly by cloning itself may be far more genetically dynamic than [...]
Stanford’s Revolutionary New Microscope Reveals Living Cells in Stunning Detail
Stanford researchers have developed a microscope that can show how nanostructures interact inside living cells at the highest resolution achieved so far. The view into living cells just got better. Stanford researchers have merged [...]
What Bundibugyo Ebola vaccines and treatments are under development
By Mariam Sunny and Jennifer Rigby May 29 (Reuters) – Global health authorities are racing to identify medical options to help contain an Ebola outbreak in eastern Democratic Republic of Congo, linked to the [...]
Why More People in Their 30s Are Suddenly Getting Colon Cancer
A major Swiss study found that colorectal cancer is becoming increasingly common in adults under 50, even as rates decline in older age groups. Researchers in Switzerland have identified a concerning trend: while colorectal [...]
Researchers Compare MS Models to Human Tissue in Search for Better Therapies
Researchers identified key differences between two widely used multiple sclerosis models, showing how each can better study myelin damage, immune responses, and repair. The findings may improve efforts to develop treatments that restore lost [...]
Scientists Discover Genetic “Off Switch” That Supercharges CAR T Cells Against Cancer
A new study reveals a possible way to make CAR T-cell therapy more durable and effective by targeting a single gene-regulating protein. CAR T-cell therapy is widely seen as a breakthrough in personalized cancer [...]
New Vitamin B12-Based Therapy Could Change How Brain Cancer Is Treated
Researchers have identified a vitamin B12–based compound that appears capable of crossing the blood–brain barrier and selectively accumulating in glioblastoma tissue. For decades, one of the biggest problems in brain cancer treatment has had [...]
Simple Fiber Supplement Cuts Knee Arthritis Pain in Just 6 Weeks, Study Finds
A daily inulin supplement may help reduce knee osteoarthritis pain while revealing a possible link between gut health, muscle function, and pain sensitivity. For millions of people living with knee osteoarthritis, managing chronic pain [...]
This Common Vitamin May Help Stop Prediabetes From Turning Into Diabetes
Vitamin D may help prevent type 2 diabetes in people with specific genetic variations, offering a possible path toward personalized diabetes prevention. More than 40% of U.S. adults have prediabetes, a condition in which [...]
Ebola, hantavirus: Is the world prepared for the next pandemic?
Funding cuts to health research and a growing antivaccine movement are making it harder than ever to respond to viruses. The World Health Organization (WHO) has declared that an Ebola outbreak in Uganda and [...]
