To grow and spread, cancer cells must evade the immune system. Investigators from Brigham and Women’s Hospital and MIT used the power of nanotechnology to discover a new way that cancer can disarm its would-be cellular attackers by extending out nanoscale tentacles that can reach into an immune cell and pull out its powerpack. Slurping out the immune cell’s mitochondria powers up the cancer cell and depletes the immune cell. The new findings, published in Nature Nanotechnology, could lead to new targets for developing the next generation of immunotherapy against cancer.
“Cancer kills when the immune system is suppressed and cancer cells are able to metastasize, and it appears that nanotubes can help them do both,” said corresponding author Shiladitya Sengupta, Ph.D., co-director of the Brigham’s Center for Engineered Therapeutics. “This is a completely new mechanism by which cancer cells evade the immune system and it gives us a new target to go after.”
To investigate how cancer cells and immune cells interact at the nanoscale level, Sengupta and colleagues set up experiments in which they co-cultured breast cancer cells and immune cells, such as T cells. Using field-emission scanning electron microscopy, they caught a glimpse of something unusual: Cancer cells and immune cells appeared to be physically connected by tiny tendrils, with widths mostly in the 100-1000 nanometer range. (For comparison, a human hair is approximately 80,000 to 100,000 nanometers). In some cases, the nanotubes came together to form thicker tubes. The team then stained mitochondria—which provide energy for cells—from the T cells with a fluorescent dye and watched as bright green mitochondria were pulled out of the immune cells, through the nanotubes, and into the cancer cells.
“By carefully preserving the cell culture condition and observing intracellular structures, we saw these delicate nanotubes and they were stealing the immune cells‘ energy source,” said co-corresponding author Hae Lin Jang, Ph.D., a principal investigator in the Center for Engineered Therapeutics. “It was very exciting because this kind of behavior had never been observed before in cancer cells. This was a tough project as the nanotubes are fragile and we had to handle the cells very gently to not break them.”
The researchers then looked to see what would happen if they prevented the cancer cells from hijacking mitochondria. When they injected an inhibitor of nanotube formation into mouse models used for studying lung cancer and breast cancer, they saw a significant reduction in tumor growth.
“One of the goals in cancer immunotherapy is to find combinations of therapies that can improve outcomes,” said lead author Tanmoy Saha, Ph.D., a postdoctoral researcher in the Center for Engineered Therapeutics. “Based on our observations, there is evidence that an inhibitor of nanotube formation could be combined with cancer immunotherapies and tested to see if it can improve outcomes for patients.”
News
How can Nanotechnology be Used to Reverse Skin Aging?
Although skin aging has not been related to many health complications, it has aesthetic issues. Some of the common symptoms of skin aging are changes in the skin texture (rough, dry, and itchy), discoloration, [...]
Emission of Fe- and Ti-Containing Nanoparticles from Coal-Fired Power Plants
In an article published in the journal Science of the Total Environment, researchers have highlighted the significance and potential risks associated with the release of nanoparticles from coal-fired power plants. Applying the single-particle inductively coupled plasma mass [...]
Covalent Organic Framework Nanofluidic Hybrid Membrane for Osmotic Energy Generation
A paper recently published in the journal ACS Applied Energy Materials demonstrated the feasibility of using a covalent organic framework (COF)-based nanofluidic hybrid membranes (NHMs) to attain enhanced interfacial ion transport for the generation of osmotic [...]
Degradable Nanocomposite Removes Antibiotics from Contaminated Water
The excess fluoroquinolones (FQs) discharged into the aquatic environment due to human activities must be removed cost-effectively. In an article published in the Journal of Cleaner Production, the authors fabricated an environment-friendly dealkaline lignin-grafted Fe3O4 nanoparticles [...]
Light-controlled reactions at the nanoscale
Controlling strong electromagnetic fields on nanoparticles is the key to triggering targeted molecular reactions on their surfaces. Such control over strong fields is achieved via laser light. Although laser-induced formation and breaking of molecular [...]
Bright Future for Nanophotonic Chips with Topological Rainbow Device
A paper recently published in the journal Nature Communications demonstrated an effective method to realize on-chip nanophotonic topological rainbow devices using the concept of synthetic dimensions. Importance of Synthetic Dimensions for the Construction of Topological Nanophotonics [...]
Green Approach to Silver Nanoparticle Fabrication with Citrus Fruits
In a study available in the journal Materials Today: Proceedings, silver nanoparticles (Ag NPs) were fabricated using a green method using Citrus X sinensis. Methylthioninium Chloride (MB) Dyes Threatening the Environment Dye and sewage drainage into [...]
Coronavirus ‘ghosts’ found lingering in the gut
Scientists are studying whether long COVID could be linked to viral fragments found in the body months after initial infection. In the chaos of the first months of the coronavirus pandemic, oncologist and geneticist [...]
Experts perplexed over number of people getting long COVID
Public health experts are divided over how many people are getting long COVID-19, a potentially debilitating condition that comes after a patient has recovered from the coronavirus. Ill effects from the condition can include [...]
Four strange COVID symptoms you might not have heard about
Well over two years into the pandemic, hundreds of thousands of COVID cases continue to be recorded around the world every day. With the rise of new variants, the symptoms of COVID have also evolved. Initially, [...]
A new method for exploring the nano-world
Nanoparticles are everywhere. They are in our body as protein aggregates, lipid vesicles, or viruses. They are in our drinking water in the form of impurities. They are in the air we breath as [...]
Breast Cancer Drug Resistance Tackled By Polymer Nanoparticles
Drug resistance is a common phenomenon, with drugs becoming less and less effective as their usage increases. To address this issue, a novel technique employing conjugated polymer-based nanoparticles is presented in the study published [...]
New imaging method makes microrobots visible in the body
Microrobots have the potential to revolutionize medicine. Researchers at the Max Planck ETH Centre for Learning Systems have now developed an imaging technique that for the first time recognises cell-sized microrobots individually and at [...]
Multifunctional Nanocrystals Enhance Cancer Cell Killing Therapies
Scientists have recently developed multifunctional hexagonal NaxWO3 nanocrystals that can serve as microwave sensitizers to kill cancer cells as well as improve the overall chemodynamic therapy (CDT). This study is available as a pre-proof in Chemical Engineering Journal. [...]
Biotech, nanomedicine, and AI combine for health breakthrough predicted by Apple genius Steve Jobs
Apple’s visionary founder, the late Steve Jobs once said, “the biggest innovations of the 21st century will be at the intersection of biology and technology”. And that prediction is coming true in the drug [...]
Making chemical separation more eco-friendly with nanotechnology
Chemical separation processes are essential in the manufacturing of many products from gasoline to whiskey. Such processes are energetically costly, accounting for approximately 10–15 percent of global energy consumption. In particular, the use of [...]
