Programming the body’s immune system to attack cancer cells has had promising results for treating blood cancers such as lymphoma and leukemia. This tactic has proven more challenging for solid tumors such as breast or lung cancers, but MIT researchers have now devised a novel way to boost the immune response against solid tumors.
By developing nanoparticle “backpacks” that hold immune-stimulating drugs, and attaching them directly to T cells, the MIT engineers showed in a study of mice that they could enhance those T cells’ activity without harmful side effects. In more than half of the treated animals, tumors disappeared completely.
“We found you could greatly improve the efficacy of the T cell therapy with backpacked drugs that help the donor T cells survive and function more effectively. Even more importantly, we achieved that without any of the toxicity that you see with systemic injection of the drugs,” says Darrell Irvine, a professor of biological engineering and of materials science and engineering, an associate director of MIT’s Koch Institute for Integrative Cancer Research, and the senior author of the study.
C. diff might not originate from external transmission but rather from within the infected patient themselves. Hospital staff dedicate significant effort to safeguard patients from infections during their hospital stay. Through practices ranging from [...]
Google says it has made a significant step in identifying disease-causing genes, which could help spot rare genetic disorders. A new model named AlphaMissense is able to confidently classify 89 per cent of all [...]
MINDWATCH study reveals cognitive peaks with everyday pleasures. Listening to music and drinking coffee are the sorts of everyday pleasures that can impact a person’s brain activity in ways that improve cognitive performance, including [...]
Moderna has developed a new and improved version of its COVID-19 vaccine. The unique formulation (mRNA-1283) reduces the vaccine's content from the full-length SARS-CoV-2 spike protein to a narrowly focused encoding of just two [...]
Breast cancer in its various forms affects more than 250,000 Americans a year. One particularly aggressive and hard-to-treat type is triple-negative breast cancer (TNBC), which lacks specific receptors targeted by existing treatments. The rapid [...]
Scientists from Nanyang Technological University, Singapore (NTU Singapore) have created a process that can upcycle most plastics into chemical ingredients useful for energy storage, using light-emitting diodes (LEDs) and a commercially available catalyst, all [...]
The mere scent of seafood can severely sicken those allergic to it — and therefore they are more likely to avoid it. Similarly, individuals who experience food poisoning from a specific dish tend to [...]
Researchers in Germany and Japan have been able to increase the diffusion of magnetic whirls, so-called skyrmions, by a factor of ten. In today’s world, our lives are unimaginable without computers. Up until now, [...]
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