Myeloperoxidase – an enzyme naturally found in our lungs – can biodegrade pristine graphene, according to the latest discovery of Graphene Flagship partners in CNRS, University of Strasbourg (France), Karolinska Institute (Sweden) and University of Castilla-La Mancha (Spain). Among other projects, the Graphene Flagship designs flexible biomedical electronic devices that will interface with the human body. Such applications require graphene to be biodegradable, so it can be expelled from the body.
To test how graphene behaves within the body, researchers analyzed how it was broken down with the addition of a common human enzyme – myeloperoxidase or MPO. If a foreign body or bacteria is detected, neutrophils surround it and secrete MPO, thereby destroying the threat. Previous work by Graphene Flagship partners found that MPO could successfully biodegrade graphene oxide.
However, the structure of non-functionalized graphene was thought to be more resistant to degradation. To test this, the team looked at the effects of MPO ex vivo on two graphene forms; single- and few-layer.
Alberto Bianco, researcher at Graphene Flagship Partner CNRS, explains: “We used two forms of graphene, single- and few-layer, prepared by two different methods in water. They were then taken and put in contact with myeloperoxidase in the presence of hydrogen peroxide. This peroxidase was able to degrade and oxidize them. This was really unexpected, because we thought that non-functionalized graphene was more resistant than graphene oxide.”
Rajendra Kurapati, first author on the study and researcher at Graphene Flagship Partner CNRS, remarks how “the results emphasize that highly dispersible graphene could be degraded in the body by the action of neutrophils. This would open the new avenue for developing graphene-based materials.”
Image Credit: Graphene Flagship
News This Week
Coronavirus tests performed in labs are the gold standard for accuracy and antigen tests are a fast and inexpensive alternative. But backers of a third type of test, developed by a Nobel Prize winner [...]
COVID-19 is a severe infectious disease that has claimed >150,000 lives and infected millions in the United States thus far, especially the elderly population. Emerging evidence has shown the virus to cause hemorrhagic and immunologic [...]
Switzerland’s Covid-19 scientific taskforce chief says hospitals across the Alpine country could be swamped with new coronavirus cases in the next two or three weeks unless the situation improves. “We estimate that the capacity limit [...]
Scientists are to increase surveillance for new coronavirus mutations amid concerns that future strains of the virus could develop at least partial resistance to antibody treatments and Covid-19 vaccines. There is no evidence that the [...]
From the moment you turn off your morning alarm, to the time you hit the pillow, your life is full of surfaces. Swiping through your phone, opening doors, putting in your PIN – there are [...]
A new report suggests that lingering “brain fog” and other neurological symptoms after COVID -19 recovery may be due to post-traumatic stress disorder (PTSD), an effect observed in past human coronavirus outbreaks such as SARS [...]
ClSARS-CoV-2, the virus that causes COVID-19, can relieve pain, according to a new study by University of Arizona Health Sciences researchers. The finding may explain why nearly half of people who get COVID-19 [...]
Contrary to president Donald Trump’s repeated declarations, the coronavirus pandemic was not — and still isn’t — totally under control. That lie is central to “Totally Under Control,” the [...]
Summary: A new study suggests COVID-19 may deplete testosterone levels in males. Findings reveal as testosterone decreased, the severity of coronavirus increased. Men who died from coronavirus infection had significantly lower mean testosterone than those [...]
It is the question scientists around the world are trying to answer: how long can the coronavirus survive in the tiny aerosol particles we exhale? In a high-security lab near Bristol, entered through a series [...]
As the COVID-19 pandemic rages on, researchers are working overtime to develop vaccines and therapies to thwart SARS-CoV-2, the virus responsible for the disease Many efforts focus on the coronavirus spike protein, which binds the [...]
A research team in Hungary pinched the coronavirus with a fine needle to measure how much force it could take before popping like a balloon. It did not. The native virion of Sars-CoV-2 – a [...]
Headaches, confusion and delirium experienced by some Covid-19 patients could be the result of the coronavirus directly invading the brain, according to a study published Wednesday. The research is still preliminary – but offers several [...]
By Boris M | Published in Coronavirus During the COVID-19 pandemic, there will be a lot of information about the virus and its effects on mental health. That’s because coronavirus and the social, financial and psychological [...]
A serious illness suffered by an Oxford University coronavirus vaccine trial participant was most likely “life-threatening”, a bioethics researcher says. But that doesn’t mean the clinical trials will be scrapped. AstraZeneca and Oxford University [...]