Course set to overcome mismatch between lab-designed nanomaterials and nature’s complexity

Cells and the machinery they encase are soft matter – shape-shifting multicomponent systems with an overwhelming richness of forms. But, these squishy packages are hard targets for potential therapeutic and diagnostic applications that exploit nanomaterials, from quantum dots that light up specific tissues to nanocages carrying drug payloads.

The problem, according to a team of 12 experts from five countries, stems from a “mismatch” between the structural complexity that nature selected over billions of years of evolution and the minimalist designs of synthetic nanomaterials, optimized for lab conditions.

Advances in nanotechnology have made it possible to control the size, shape, composition, elasticity and chemical properties of laboratory-made nanomaterials. Yet many of these materials do not to function as expected in the body. In a recent issue of Biointerphases, from AIP Publishing, the team homes in on biomembranes – the gatekeeping bilipid-layers and proteins surrounding cells. They explore the barriers a synthetic nanomaterial must breach to enter a cell and achieve its intended purpose.

Read more at nanodaily.com

Image Credit:  From the article

News This Week

NanoApps Medical Near-Term Projects

NanoApps Medical is investigating the possibility that superparamagnetic nanoparticles (SPIONs) and other classes of nanoparticles (e.g., gold coated nanoshells) might have the capacity to target cancerous tumors, metastasizing cancer cells, pathogens, etc. to deactivate/eliminate [...]

‘Please do not switch me off!’ People heed begging robot

If a little humanoid robot begged you to not shut it off, would you show compassion? In an experiment designed to investigate how people treat robots when they act like humans, many participants struggled [...]

How Artificial Intelligence is Changing Radiology, Pathology

Artificial intelligence and machine learning tools have the potential to analyze large datasets and extract meaningful insights to enhance patient outcomes, an ability that is proving helpful in radiology and pathology. Images obtained by [...]

Nanoparticle-Based Combination Therapy to Treat Breast, Prostate Cancer

Researchers at the University of East Anglia have developed a new nanoparticle-based cancer therapy to deliver a combination therapy directly to cancer cells. The new therapy, which has been demonstrated to make prostate cancer [...]

AI: ChronWell CEO On Why Consolidation in Healthcare Is A Good Thing

When Joe Rubinsztain started gMed, he was admittedly young—only a few years removed from medical school— and he just didn’t understand leadership that well. “I needed to be abreast of everything and understand everything [...]

Artificial Intelligence for Medical Imaging Market to Top $2B

Healthcare organizations are likely to see a rapidly growing market around artificial intelligence tools for medical imaging, a new report predicts. The market for artificial intelligence (AI) tools to process and analyze medical imaging [...]

Tuberculosis is a killer, but scientists are fighting back with nanobots

Tuberculosis, a bacterial disease which predominantly affects the lungs, isn’t all that common a sight in the United States. On average, fewer than 10,000 cases are reported each year in a country with [...]

Integrated sensor could monitor brain aneurysm treatment

Implantation of a stent-like flow diverter can offer one option for less invasive treatment of brain aneurysms – bulges in blood vessels – but the procedure requires frequent monitoring while the vessels heal. Now, [...]

2018-04-29T13:47:01+00:00

Leave A Comment